Supercritical antisolvent coprecipitation mechanisms

Prosapio, Valentina; Marco, Iolanda De; Reverchon, Ernesto

doi:10.1016/j.supflu.2018.04.021

Cited by 69 publications

(42 citation statements)

References 129 publications

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“…[45,46] In this paper, well-defined spherical microparticles were successfully produced for both the PVP/KET and zein/AMP systems. In agreement with the literature, [21] the present paper shows that the polymeric carrier, which has to be processable by SAS, strongly influences the morphology of the coprecipitated particles. Indeed, the coprecipitated powders were characterized by micrometric dimensions as well as the micronized polymer (without the drug).…”

Section: Discussionsupporting

confidence: 92%

“…Supercritical carbon dioxide (SC-CO 2 ) assisted technologies [16][17][18][19][20] allow us to overcome these limits; among these, supercritical antisolvent (SAS) precipitation stands out for the production of nanoparticles and microparticles of different materials. [21,22] However, SAS coprecipitation has been successful only in some cases: the main failure is achieved when the polymer and the active principle precipitate separately. In general, this occurs when nanoparticles are formed, whereas, the production of microparticles seems to ease the effective coprecipitation.…”

Section: Introductionmentioning

confidence: 99%

“…In general, this occurs when nanoparticles are formed, whereas, the production of microparticles seems to ease the effective coprecipitation. [21] The achievement of a morphology rather than another is related to the choice of the operating conditions used to coprecipitate the powders and to the interactions among the solute, the solvent, and the antisolvent. [23] Another key parameter is related to the choice of the carrier.…”

Section: Introductionmentioning

confidence: 99%

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Supercritical antisolvent coprecipitation in the pharmaceutical field: Different polymeric carriers for different drug releases

Franco

Marco

2020

Can J Chem Eng

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The supercritical antisolvent process (SAS) was employed to obtain polymer/drug coprecipitated powders. Indeed, processes based on the use of supercritical fluids allow us to obtain polymer/active drug coprecipitated microparticles with tunable bioavailability. In this work, two different biocompatible polymers were selected to be used as carriers for obtaining drug microparticles with different releases for different applications: polyvinylpyrrolidone (PVP) was coprecipitated with ketoprofen to obtain a rapid drug release and zein was coprecipitated with ampicillin to obtain a controlled drug release. The experiments were performed both on a bench‐scale and a pilot‐scale plant. Ketoprofen is one of the most prescribed non‐steroidal anti‐inflammatory drugs. It is poorly soluble in water and, to overcome this inconvenience, in this work, it was coprecipitated with PVP. In correspondence with the optimized polymer/drug ratio, the dissolution rate of the active principle in the coprecipitated particles was about three times higher than the one of the unprocessed ketoprofen. The second model drug under study in this paper is ampicillin, a semi‐synthetic penicillin that is one of the most commonly prescribed broad‐spectrum antibiotics. Prolonging the release of the drug would imply a reduction in the number of administrations and, therefore, of the side effects associated with too high dosages. For this purpose, in this work, ampicillin was coprecipitated with zein. Zein/ampicillin microparticles were produced up to a polymer/drug ratio of 5/1 w/w; in this case, the antibiotic coprecipitated with zein reaches 90% of its dissolution in about 14 hours, while the unprocessed antibiotic takes about 3 hours to dissolve.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Supercritical antisolvent coprecipitation in the pharmaceutical field: Different polymeric carriers for different drug releases

Franco

Marco

2020

Can J Chem Eng

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“…However, the use of SAS to produce coprecipitates has not always been successful. In some works, irregular and coalescing particles with wide particle size distribution [31] and low encapsulation efficiency [32] were obtained and the demonstration of an effective coprecipitation through the improvement of the drug dissolution properties is hardly reported [33].…”

Section: Take Down Policymentioning

confidence: 99%

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Matos

Prosapio

et al. 2019

Journal of CO2 Utilization

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The poor solubility of curcumin (CURC) in aqueous media leads to a low bioavailability, which prevents its application in pharmaceutical formulations. In this work, the Supercritical Antisolvent process (SAS) was used to produce coprecipitates of CURC and poly (vinyl pyrrolidone) (PVP) from mixtures of ethanol and acetone. The effects of operating parameters: pressure, temperature, solution concentration, drug/polymer mass ratio and solution flow rate were analysed for a 70-30 (v/v) acetone-ethanol mixture. It was found that the composition of acetone in the solvent mixture is the parameter that affects particle size and curcumin recovery the most. The thermal behaviour, crystallinity, molecular interactions, apparent solubility, release profile of the coprecipitates and possible degradation of curcumin were investigated. The results showed that the SAS process is effective in preparing amorphous formulations of CURC/PVP with an apparent solubility of more than 600 times higher than that of the physical mixture of the raw compounds.

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“…When the system reaches equilibrium, the mixture comprised of the bioactive compound, the wall material and the organic solvent is injected into the precipitation vessel [ 125 ]. This technique has been extensively used for the encapsulation and production of micronized particles for food, polymer and pharmaceutical applications [ 53 , 92 , 126 , 127 , 128 , 129 , 130 ].…”

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds

Klettenhammer

Ferrentino

Morozova

et al. 2020

Foods

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In recent years, the demand for nutritive, functional and healthy foods has increased. This trend has induced the food industry to investigate novel technologies able to produce ingredients with enhanced functional and physicochemical properties. Among these technologies, one of the most promising is the encapsulation based on supercritical fluids. Thanks to the inherent absence of organic solvent, the low temperature of the process to reach a supercritical state and the capacity to dissolve lipid soluble bioactives, the encapsulation with supercritical carbon dioxide represents a green technology to produce several functional ingredients, with enhanced stability, high load and tailored protection from environmental factors. Furthermore, from the fine-tuning of the process parameters like temperature, pressure and flow rate, the resulting functional ingredient can be easily designed to tailor the controlled release of the bioactive, or to reach specific levels of taste, odor and color. Accordingly, the aim of the present review is to summarize the state of the art of the techniques based on supercritical carbon dioxide for the encapsulation of bioactive compounds of food interest. Pros and cons of such techniques will be highlighted, giving emphasis to their innovative aspects that could be of interest to the food industry.

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Supercritical antisolvent coprecipitation mechanisms

Cited by 69 publications

References 129 publications

Supercritical antisolvent coprecipitation in the pharmaceutical field: Different polymeric carriers for different drug releases

Supercritical antisolvent coprecipitation in the pharmaceutical field: Different polymeric carriers for different drug releases

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds

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