Supercritical anti-solvent fractionation of Artemisia absinthium L. conventional extracts: tracking artemetin and casticin

Langa, Elisa; Pardo, Juan I.; Giménez-Rota, Carlota; González-Coloma⊥, Azucena; Hernáiz, María J.; Mainar, Ana M.

doi:10.1016/j.supflu.2019.05.003

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…The degree of expansion is generally increased at low temperatures and high pressures [17,18]. Obviously, solutes with higher molecular weights are precipitated before those with lower molecular weights when a mixture of solutes is present in a solvent; as a result, the fractionation of solutes can be achieved [19,20,21,22]. CO 2 has a moderate critical temperature and pressure (31.1 °C and 7.4 MPa) [23] and can be dissolved in most organic solvents for solvent expansion.…”

Section: Introductionmentioning

confidence: 99%

Purification of Polybutylene Terephthalate by Oligomer Removal Using a Compressed CO2 Antisolvent

Huang

Tan

2019

Polymers

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In this study, the cyclic oligomers in the highly chemically resistant polyester polybutylene terephthalate (PBT) were effectively removed using a compressed CO2 antisolvent technique in which 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was used as the solvent. In addition to the oligomers, tetrahydrofuran was completely removed because of its low molecular weight and liquid state. The effects of the operating variables, including temperature, pressure, and the PBT concentration in HFIP, on the degree of removal of the oligomers were systematically studied using experimental design and the response surface methodology. The most appropriate operating conditions for the purification of PBT were 8.3 MPa and 23.4 °C when using 4.5 wt % PBT in HFIP. Under these conditions, the cyclic trimers and dimers could be removed by up to 81.4% and 95.7%, respectively, in a very short operating time.

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Section: Introductionmentioning

confidence: 99%

Purification of Polybutylene Terephthalate by Oligomer Removal Using a Compressed CO2 Antisolvent

Huang

Tan

2019

Polymers

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“…The pre-treated material, previously ground and sieved, was defatted in a first stage to facilitate the obtaining of the antioxidant fraction. This stage was usually carried out by means of maceration in hexane [ 41 , 45 ], but in a more recent study, supercritical extraction with CO 2 was used [ 51 ]. This is due to the advantages offered by this type of extraction; since it is a non-toxic solvent, its polarity facilitates the extraction of lipophilic compounds and generates solvent-free final products because it can be easily removed by lowering the pressure.…”

Section: Resultsmentioning

confidence: 99%

“…In this way, two fractions enriched in different compounds are obtained. This technique has been used to obtain fractions rich in compounds of interest having various bioactivities such as biopesticides [ 42 ], or antiproliferative [ 43 ], antimicrobial [ 44 ], or antioxidant activity [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

et al. 2021

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The growing interest in the cosmetic industry in using compounds of natural and sustainable origin that are safe for humans is encouraging the development of processes that can satisfy these needs. Chlorogenic acid (CHA), caffeic acid (CAF) and ferulic acid (FA) are three compounds widely used within the cosmetic industry due to their functionalities as antioxidants, collagen modifiers or even as radiation protectors. In this work, two advanced separation techniques with supercritical CO2 are used to obtain these three compounds from Calendula officinalis, and these are then evaluated using a computational skin permeability model. This model is encompassed by the COSMO-RS model, the calculations of which make it possible to study the behaviour of the compounds in the epidermis. The results show that both CAF and FA are retained in the stratum corneum, while CHA manages to penetrate to the stratum spinosum. These compounds were concentrated by antisolvent fractionation with super-critical CO2 using a Response Surface Methodology to study the effect of pressure and CO2 flow rate. CHA, CAF and FA were completely retained in the precipitation vessel, with concentrations between 40% and 70% greater than in the original extract. The conditions predicted that the optimal overall yield and enrichment achieved would be 153 bar and 42 g/min.

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“…To produce extracts enriched in specific compounds, they can be fractioned by using scCO2 as anti-solvent in several conditions of pressure and temperature, providing their precipitation, as observed in studies with Rosmarinus officinalis L. (Rosemary) (Quintana, Villanueva-Bermejo et al 2019), Artemisia absinthium L. (Wormwood) (Langa, Pardo et al 2019), Eugenia uniflora L. (Pitanga, leaves) (Garmus, Kopf et al 2019), green propolis (Monroy, Rodrigues et al 2018), and Baccharis dracunculifolia DC. (Alecrim-do-campo) (Paula, Sousa et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Supercritical extraction from red propolis and fractionation of its hydroalcoholic and ethanolic extracts using CO2 as anti-solvent / Extração supercrítica da própolis vermelha e fracionamento de seus extratos hidroalcoólicos e etanolicos usando CO2 como anti-solvente

Monroy¹,

Rodrigues²,

Rodrigues³

et al. 2022

BJDV

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Technologies for extraction and fractionation of phenolic compounds from a typical propolis from northeastern Brazil, called red propolis, using supercritical fluids may represent an environmentally correct alternative to the current extraction processes, as they are included in the concept of "green chemistry". The objective of this work was to extract and fractionate the phenolic compounds from red propolis: I) Using supercritical carbon dioxide (scCO2) as solvent and ethanol as co-solvent to obtain an ethanolic extract; II) Using scCO2 as solvent and a mixture of ethanol: water (70:30, v / v) as co-solvent to obtain a hydroalcoholic extract. After extraction, the ethanolic and hydroalcoholic extracts were fractionated using scCO2 as antisolvent at a constant temperature of 50 ºC, subjected to four gradual pressures, in a sequential of separators operated at 200, 100 and 80 bar, at the end, atmospheric pressure (1.013 bar). The procedure was characterized according to extraction yield; total phenols, total flavonoids, antioxidant activity and color. It was found that the pressure influenced the yield and the concentration of the phenolic compounds in the extracts, demonstrating that the most efficient fractionation process occurred in the first and second separators. Overall, all extracts showed high antioxidant activity.

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Supercritical anti-solvent fractionation of Artemisia absinthium L. conventional extracts: tracking artemetin and casticin

Cited by 11 publications

References 26 publications

Purification of Polybutylene Terephthalate by Oligomer Removal Using a Compressed CO2 Antisolvent

Purification of Polybutylene Terephthalate by Oligomer Removal Using a Compressed CO2 Antisolvent

Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

Supercritical extraction from red propolis and fractionation of its hydroalcoholic and ethanolic extracts using CO2 as anti-solvent / Extração supercrítica da própolis vermelha e fracionamento de seus extratos hidroalcoólicos e etanolicos usando CO2 como anti-solvente

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