Superabsorbing Metasurfaces with Hybrid Ag–Au Nanostructures for Surface‐Enhanced Raman Spectroscopy Sensing of Drugs and Chemicals

Gao, Jun; Zhang, Nan; Ji, Dengxin; Song, Haomin; Liu, Youhai; Zhou, Lyu; Sun, Zhi; Jornet, Josep Miquel; Thompson, Alexis C.; Collins, Rebecca L.; Song, Yun; Jiang, Suhua; Gan, Qiaoqiang

doi:10.1002/smtd.201800045

Cited by 33 publications

(23 citation statements)

References 55 publications

(75 reference statements)

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“…As illustrated in Figure a, our structure started from the direct deposition of random metallic nanoparticles (NP): [ 38 ] a silver (Ag) film was deposited onto a pre‐cleaned glass substrate using electron‐beam evaporation. Following previously reported lithography‐free fabrication technique, [ 39,40 ] thermal annealing was used to manipulate the average morphology (e.g., size, spacing) of the first layer of Ag NPs. Then, these NPs were covered by a 1‐nm alumina (Al 2 O 3 ) film deposited by ALD.…”

Section: Resultsmentioning

confidence: 99%

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

Zhang

Singer

et al. 2020

Advanced Optical Materials

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Metallic nanostructures with nanogap features can confine electromagnetic fields into extremely small volumes. In particular, as the gap size is scaled down to sub‐nanometer regime, the quantum effects for localized field enhancement reveal the ultimate capability for light–matter interaction. Although the enhancement factor approaching the quantum upper limit has been reported, the grand challenge for surface‐enhanced vibrational spectroscopic sensing remains in the inherent randomness, preventing uniformly distributed localized fields over large areas. Herein, a strategy to fabricate high‐density random metallic nanopatterns with accurately controlled nanogaps, defined by atomic‐layer‐deposition and self‐assembled‐monolayer processes, is reported. As the gap size approaches the quantum regime of ≈0.78 nm, its potential for quantitative sensing, based on a record‐high uniformity with the relative standard deviation of 4.3% over a large area of 22 mm × 60 mm, is demonstrated. This superior feature paves the way towards more affordable and quantitative sensing using quantum‐limit‐approaching nanogap structures.

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Section: Resultsmentioning

confidence: 99%

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

Zhang

Singer

et al. 2020

Advanced Optical Materials

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“…SERS commonly uses the unique LSPR properties of plasmonic nanomaterials to measure spectroscopic vibrations of the detected molecules on or near the surface of plasmonic nanostructures, which has opened up new horizons for growing biodetection needs . However, it is highly difficult for most of these constructs to maintain their morphologies and properties under harsh conditions such as long‐term laser exposure and highly acidic and alkaline media .…”

Section: Applications Of Graphitic Nanocapsulesmentioning

confidence: 99%

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

Liu

Zhu

et al. 2019

Small Methods

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To date, a variety of graphitic nanomaterial-based applications have facilitated the development of biomedical applications, such as carbon quantumdot-based biosensors and imaging systems, [14][15][16][17] graphene oxide-based biosensors [18][19][20][21][22] and drug delivery systems, [20,[23][24][25] and carbon nanotube-based therapy applications. [26][27][28][29] Compared with other widely used nanomaterials, graphitic nanomaterials show superior fluorescence quenching performance, larger Raman scattering cross-sections than conventional organic Raman tags, [30] and better biocompatibility. [31] With the goal of broadening their applications, great attention has been focused on integrating graphitic materials with other inorganic nanomaterials such as noble metals [32,33] and magnetic nanomaterials. [34,35] Such graphitic nanomaterial-metal hybrid nanostructures make full use of the excellent properties of both graphitic and metal nanomaterials, and have much wider application prospect in bioanalysis. [36] However, most of the reported hybrid nanostructures, in which metal nanomaterials are exposed on the surface of graphitic nanomaterials encounter difficulty in maintaining their morphologies and stable properties under harsh conditions, such as long-term laser irradiation or strong acidic environments, which might cause inaccurate bioanalytical results and even potential biotoxicity. [37][38][39] Therefore, it is critical to prepare novel graphitic nanomaterials with superstability to meet the demands of reliable bioanalysis and biomedicine.As a type of novel graphite nanomaterial with a core-shell structure, superior physicochemical properties, good biocompatibility, superior stability, and controllable size, graphitic nanocapsules have been extensively applied in biosensing, [40,41] bioimaging, [42,43] drug delivery, [43,44] and cancer treatment. [45] Benefiting from the large surface area of the outside graphitic shell, graphitic nanocapsules supply superior nanoplatforms for drugs and targeting-molecule loading, which further broadens their biomedical applications. [42,44,46] In addition, the graphitic shell of graphitic nanocapsules possesses several unique Raman scattering bands and can act as a Raman signal tag or stable internal standard (IS) for accurate surface enhanced Raman scattering (SERS) analysis. [46,47] Particularly, the 2D band (≈2650 cm −1 ) within the cellular Raman-silent region is beneficial to avoiding the interference signals from Benefiting from their unique physicochemical properties, graphitic nanocapsules with a core-shell structure have attracted tremendous interest in bioanalysis and biomedicine recently. Using rational design, various types of graphitic nanocapsules with controllable properties are prepared to meet the demands of different biomedical applications. Graphitic nanocapsules exhibit excellent stability and superior capacity for loading nucleic acids, proteins, small molecules, and drugs due to the large specific surface area of their graphitic shells. Moreover, usin...

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“…[6][7][8][9] Among them, SERS is an extensively studied analytical tool that provides molecule-specific information on the molecular structure and chemical composition of analytes through Raman scattering. It is now generally accepted that the SERS enhancement arises from the enlarged local electromagnetic (EM) fields near a nanostructured metal system, which is resulted from localized surface plasmon resonances (LPRs), 10 known as plasmonic "hot-spots" that occur near sharp asperities and in nanometer gaps between metal nanostructures such as nanoparticles (NPs), 11,12 NP-spacer-film systems, 13,14 etc. Generally, the number and intensity of plasmonic hot-spots largely determines the SERS capability of a given substrate.…”

Section: Introductionmentioning

confidence: 99%

Broadband SERS detection with disordered plasmonic hybrid aggregates

et al. 2020

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Superabsorbing Metasurfaces with Hybrid Ag–Au Nanostructures for Surface‐Enhanced Raman Spectroscopy Sensing of Drugs and Chemicals

Cited by 33 publications

References 55 publications

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

Broadband SERS detection with disordered plasmonic hybrid aggregates

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