Super-resolution Optical Measurement of Nanoscale Photoacid Distribution in Lithographic Materials

Berro, Adam J.; Berglund, Andrew J.; Carmichael, Peter T.; Kim, Jong Seung; Liddle, J. Alexander

doi:10.1021/nn304285m

Cited by 21 publications

(20 citation statements)

References 48 publications

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“…For example, material studies that utilized super-resolution techniques have successfully mapped polymer proton distribution24, mapped emitting sites within single conjugated polymer25, added tools for optimizing lithography techniques24, increased fundamental insight on hot-spot formation in nanostructures26, directly observed catalytic effects of metallic nanoparticles on a molecular scale27, and tracked single polymer molecules28. The vast majority of optical super-resolution technologies rely on extrinsic contrast agents.…”

mentioning

confidence: 99%

Subsurface Super-resolution Imaging of Unstained Polymer Nanostructures

Urban

Dong

Nguyen

et al. 2016

Sci Rep

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Optical imaging has offered unique advantages in material researches, such as spectroscopy and lifetime measurements of deeply embedded materials, which cannot be matched using electron or scanning-probe microscopy. Unfortunately, conventional optical imaging cannot provide the spatial resolutions necessary for many nanoscopic studies. Despite recent rapid progress, super-resolution optical imaging has yet to be widely applied to non-biological materials. Herein we describe a method for nanoscopic optical imaging of buried polymer nanostructures without the need for extrinsic staining. We observed intrinsic stochastic fluorescence emission or blinking from unstained polymers and performed spatial-temporal spectral analysis to investigate its origin. We further applied photon localization super-resolution imaging reconstruction to the detected stochastic blinking, and achieved a spatial resolution of at least 100 nm, which corresponds to a six-fold increase over the optical diffraction limit. This work demonstrates the potential for studying the static heterogeneities of intrinsic polymer molecular-specific properties at sub-diffraction-limited optical resolutions.

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mentioning

confidence: 99%

Subsurface Super-resolution Imaging of Unstained Polymer Nanostructures

Urban

Dong

Nguyen

et al. 2016

Sci Rep

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“…For example, in superresolution imaging of a static structure, the mean intensity of a nominally single emitter informs of whether the signal is the result of multiple emitters instead. 25 In applications of particle tracking in which the emitters are moving, there is a strong justification, after the experiment, for assuming a certain number of emitters. If there were a large number of independent emitters, then an undetected independence in motion and intensity of these emitters would imply an extraordinary correlation between the emitters, invalidating the assumption of independence.…”

Section: Measurement Frameworkmentioning

confidence: 99%

“…Vibration and drift of a microscope 25 can move the sample, potentially out of the field of view or depth of focus during the acquisition of data. This is a significant issue in tracking measurements with long intervals of data acquisition.…”

Section: Measurement Frameworkmentioning

confidence: 99%

“…Even when the particle remains in the field of view, loss of signal from the particle due to photobleaching can limit the temporal range of the measurement. 25 Sec. IVD discusses this and other effects resulting from the choice of nanoparticle.…”

Section: Measurement Frameworkmentioning

confidence: 99%

“…Photoactivated localization microscopy enables superresolution imaging of the spatial distribution of photoacid molecules in two dimensions with a precision of 50 nm limited by unintended motion of the microscope. 25 Both ultraviolet light and protonation can activate the organic fluorophores attached to the photoacid molecules.…”

Section: Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Optical tracking of nanoscale particles in microscale environments

Mathai

Liddle

Stavis

2016

Applied Physics Reviews

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The trajectories of nanoscale particles through microscale environments record useful information about both the particles and the environments. Optical microscopes provide efficient access to this information through measurements of light in the far field from nanoparticles. Such measurements necessarily involve trade-offs in tracking capabilities. This article presents a measurement framework, based on information theory, that facilitates a more systematic understanding of such trade-offs to rationally design tracking systems for diverse applications. This framework includes the degrees of freedom of optical microscopes, which determine the limitations of tracking measurements in theory. In the laboratory, tracking systems are assemblies of sources and sensors, optics and stages, and nanoparticle emitters. The combined characteristics of such systems determine the limitations of tracking measurements in practice. This article reviews this tracking hardware with a focus on the essential functions of nanoparticles as optical emitters and microenvironmental probes. Within these theoretical and practical limitations, experimentalists have implemented a variety of tracking systems with different capabilities. This article reviews a selection of apparatuses and techniques for tracking multiple and single particles by tuning illumination and detection, and by using feedback and confinement to improve the measurements. Prior information is also useful in many tracking systems and measurements, which apply across a broad spectrum of science and technology. In the context of the framework and review of apparatuses and techniques, this article reviews a selection of applications, with particle diffusion serving as a prelude to tracking measurements in biological, fluid, and material systems, fabrication and assembly processes, and engineered devices. In so doing, this review identifies trends and gaps in particle tracking that might influence future research.

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Observation of Interfacial Damage in a Silk‐Epoxy Composite, Using a Simple Mechanoresponsive Fluorescent Probe

Woodcock

Beams

Davis

et al. 2017

Adv Materials Inter

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Polymer composites are found throughout the world both natural and artificial in origin. In the vast majority of applications, composites serve as structural support or reinforcement roles. Demand for lightweight tough composites is growing in multiple application spaces such as areospace, biomaterials, and infrastructure with physical properties as diverse as the applications. The unifying component in all composites is the presence of an interphase. Many measurement techniques and measurement tools have been developed for the study of this crucial region in composite materials. Many of these methods are great for the measurment and study of bulk properties or model systems. However, development of methods that permit the direct observation of interactions at the interphase during applied stress are needed. Here we employ fluorescence lifetime imaging and hyperspectral imaging to observe activation of a fluorogenic dye at the composite interface as a result of applied stress. The advantages of this sytem include commercial availability of the dye precursor, and simple one‐pot functionalization. The attachment of the dye at the interface is easily monitored through emission wavelength shifts and fluorescence lifetime variations. Interfacial mechano‐responsive dyes have potential for both fundamental studies as well as industrial use as a structural health monitoring tool.

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Super-resolution Optical Measurement of Nanoscale Photoacid Distribution in Lithographic Materials

Cited by 21 publications

References 48 publications

Subsurface Super-resolution Imaging of Unstained Polymer Nanostructures

Subsurface Super-resolution Imaging of Unstained Polymer Nanostructures

Optical tracking of nanoscale particles in microscale environments

Observation of Interfacial Damage in a Silk‐Epoxy Composite, Using a Simple Mechanoresponsive Fluorescent Probe

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