Super-resolution imaging of antibody-conjugated biodegradable periodic mesoporous organosilica nanoparticles for targeted chemotherapy of prostate cancer

Das, Pradip; Pujals, Sílvia; Ali, Lamiaa M. A.; Gary‐Bobo, Magali; Albertazzi, Lorenzo; Durand, Jean‐Olivier

doi:10.1039/d3nr01571h

Cited by 5 publications

(5 citation statements)

References 61 publications

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“…Controlled drug release is the outcome of the interaction of these phenomena . Another significant characteristic of nanogels was their dependence on gelatinase for drug release, which showed a higher rate of drug release in samples with gelatinase than in those without gelatinase . It was discovered that samples without gelatinase demonstrated a slower release of the tildipirosin composite nanogels than samples with gelatinase.…”

Section: Resultsmentioning

confidence: 99%

“…34 Another significant characteristic of nanogels was their dependence on gelatinase for drug release, which showed a higher rate of drug release in samples with gelatinase than in those without gelatinase. 35 It was discovered that samples without gelatinase demonstrated a slower release of the tildipirosin composite nanogels than samples with gelatinase. And 96.10% of the tildipirosin in the tildipirosin composite nanogels with gelatinase was released after 8 h, but the cumulative release of tildipirosin without gelatinase was 85.40 ± 2.10%.…”

Section: Gelatinase-responsive Release Study Swelling Ratios (Srs)mentioning

confidence: 99%

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Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum–Gelatin Composite Nanogels

Li,

Liu,

Dou

et al. 2024

Langmuir

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Tildipirosin has no significant inhibitory effect on intracellular bacteria because of its poor membrane permeability. To this end, tildipirosin-loaded xanthan gum− gelatin composite nanogels were innovatively prepared to improve the cellular uptake efficiency. The formation of the nanogels via interactions between the positively charged gelatin and the negatively charged xanthan gum was confirmed by powder X-ray diffraction and Fourier transform infrared. The results indicate that the optimal tildipirosin composite nanogels possessed a 3D network structure and were shaped like a uniformly dispersed ellipse, and the particle size, PDI, and ζ potential were 229.4 ± 1.5 nm, 0.26 ± 0.04, and −33.2 ± 2.2 mV, respectively. Interestingly, the nanogels exhibited gelatinase-responsive characteristics, robust cellular uptake via clathrin-mediated endocytosis, and excellent sustained release. With those pharmaceutical properties provided by xanthan gum−gelatin composite nanogels, the anti-Staphylococcus aureus activity of tildipirosin was remarkably amplified. Further, tildipirosin composite nanogels demonstrated good biocompatibility and low in vivo and in vitro toxicities. Therefore, we concluded that tildipirosin-loaded xanthan gum−gelatin composite nanogels might be employed as a potentially effective gelatinase-responsive drug delivery for intracellular bacterial infection.

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Section: Resultsmentioning

confidence: 99%

Section: Gelatinase-responsive Release Study Swelling Ratios (Srs)mentioning

confidence: 99%

Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum–Gelatin Composite Nanogels

Li,

Liu,

Dou

et al. 2024

Langmuir

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“…In response to external stimuli, nanoparticle-based drug delivery platforms undergo changes in their conformation, stability, solubility, precipitation, structure porosity and hydrophilic/hydrophobic balance, finally leading to the release of entrapped active molecules. 9,10…”

Section: Introductionmentioning

confidence: 99%

“…7,8 In response to external stimuli, nanoparticle-based drug delivery platforms undergo changes in their conformation, stability, solubility, precipitation, structure porosity and hydrophilic/hydrophobic balance, nally leading to the release of entrapped active molecules. 9,10 Poly(N-isopropylacrylamide) (pNIPAM) containing both hydrophobic and hydrophilic groups is one of the most studied smart polymers. Considering its pH sensitivity, low toxicity, solubility in water, low critical solution temperature (LCST) and thermo-responsive properties, it is a good candidate for applications in cell culture, drug delivery systems, scaffolds for tissue engineering and skin wound repair.…”

Section: Introductionmentioning

confidence: 99%

Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities

Icriverzi,

Florian,

Bonciu

et al. 2024

Nanoscale Adv.

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“…Among the various external stimuli like temperature, pH and light irradiation, pH has shown more interest, this is because various tissues and organelles, such as endosomes/lysosomes, extra-tumoral environments, and inflamed regions, experience a substantial decrease in pH than normal tissues 15 . Therefore, development of pH-responsive nanocarriers seems like a good way to improve the therapeutic usefulness of nanocarrier-based drug delivery systems.Recenty periodic mesoporous organosilica nanoparticles (nano PMOS), Mesoporous Silica and Oligo Methacrylates-Based Dual-Responsive Hybrid Nanogels were used for targeted chemotherapy of Prostate cancer 16 , 17 .However, there is limited literature on pH-responsive nanogels loaded with anticancer drugs specifically for prostate cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of elastin nanogels encapsulated decursin for castrated resistance prostate cancer therapy

Rather,

Selvakumar,

Srinivas

et al. 2024

Sci Rep

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Nanogels offer hope for precise drug delivery, while addressing drug delivery hurdles is vital for effective prostate cancer (PCa) management. We developed an injectable elastin nanogels (ENG) for efficient drug delivery system to overcome castration-resistant prostate cancer (CRPC) by delivering Decursin, a small molecule inhibitor that blocks Wnt/βcatenin pathways for PCa. The ENG exhibited favourable characteristics such as biocompatibility, flexibility, and low toxicity. In this study, size, shape, surface charge, chemical composition, thermal stability, and other properties of ENG were used to confirm the successful synthesis and incorporation of Decursin (DEC) into elastin nanogels (ENG) for prostate cancer therapy. In vitro studies demonstrated sustained release of DEC from the ENG over 120 h, with a pH-dependent release pattern. DU145 cell line induces moderate cytotoxicity of DEC-ENG indicates that nanomedicine has an impact on cell viability and helps strike a balance between therapeutics efficacy and safety while the EPR effect enables targeted drug delivery to prostate tumor sites compared to free DEC. Morphological analysis further supported the effectiveness of DEC-ENG in inducing cell death. Overall, these findings highlight the promising role of ENG-encapsulated decursin as a targeted drug delivery system for CRPC.

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Super-resolution imaging of antibody-conjugated biodegradable periodic mesoporous organosilica nanoparticles for targeted chemotherapy of prostate cancer

Abstract: Biodegradable periodic mesoporous organosilica nanoparticles (nanoPMOs) are widely used as responsive drug delivery platforms for targeted chemotherapy of cancer. However, the evaluation of their properties such as surface functionality and...

Cited by 5 publications

References 61 publications

Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum–Gelatin Composite Nanogels

Enhanced Cellular Delivery of Tildipirosin by Xanthan Gum–Gelatin Composite Nanogels

Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities

Facile synthesis of elastin nanogels encapsulated decursin for castrated resistance prostate cancer therapy

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