Super-capacity information-carrying systems encoded with spontaneous Raman scattering

Tang, Yuchen; He, Caili; Xie, Zheng; Chen, Xuqi; Gao, Tingjuan

doi:10.1039/c9sc05133c

Cited by 28 publications

(19 citation statements)

References 34 publications

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“…[5] Although it is possible to obtain more novel Raman‐active polymers based on unique triple‐bond vibrations by changing the different types of monomers to form polymers, this strategy relies on monomers with different molecular structures, which remains challenging due to complex organic synthesis design. To overcome this challenge, we propose synthesizing additional Raman‐active polymers by encoding the intensities of triple bonds via adjustment of the Raman triple‐bond signal ratio to obtain a unique Raman spectral signature [10] …”

Section: Resultsmentioning

confidence: 99%

Precise Encoding of Triple‐Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application

Zhu

Cai

et al. 2021

Angewandte Chemie

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Stimulated Raman scattering (SRS) microscopy in combination with innovative tagging strategies offers great potential as a universal high‐throughput biomedical imaging tool. Here, we report rationally tailored small molecular monomers containing triple‐bond units with large Raman scattering cross‐sections, which can be polymerized at the nanoscale for enhancement of SRS contrast with smaller but brighter optical nanotags with artificial fingerprint output. From this, a class of triple‐bond rich polymer nanoparticles (NPs) was engineered by regulating the relative dosages of three chemically different triple‐bond monomers in co‐polymerization. The bonding strategy allowed for 15 spectrally distinguishable triple‐bond combinations. These accurately structured nano molecular aggregates, rather than long‐chain macromolecules, could establish a universal method for generating small‐sized biological SRS imaging tags with high sensitivity for high‐throughput multi‐color biomedical imaging.

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Section: Resultsmentioning

confidence: 99%

Precise Encoding of Triple‐Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application

Zhu

Cai

et al. 2021

Angewandte Chemie

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“…Recently, Gao and co-workers developed super-capacity information-carrying systems by tuning vibrational signal intensities in multiple bands of Raman-silent regions. 41 They generated a library of alkyne compounds where the Raman shifts located from 2000 to 2300 cm −1 . The different Raman codes can be effectively generated through mixing the compounds with different amount ratios, thereby generating the distinct relative Raman intensities (Fig.…”

Section: Spectroscopic Encodingmentioning

confidence: 99%

Organic micro/nanoscale materials for photonic barcodes

2020

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“…This feature provides a significant advantage for multicolor microscopic imaging and supercapacity information encoding using Raman scattering. 1 − 6 However, the low cross section of Raman scattering places one of the major obstacles when Raman spectroscopy and imaging are applied to identify trace amounts of components in complicated systems that require ultrasensitive detection, e.g., live cells. 7 − 11 Many strategies and techniques, such as coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS), surface-enhanced Raman scattering (SERS), and tip-enhanced Raman scattering (TERS), have been developed to boost Raman signals of molecules.…”

Section: Introductionmentioning

confidence: 99%

Azo-Enhanced Raman Scattering for Enhancing the Sensitivity and Tuning the Frequency of Molecular Vibrations

et al. 2021

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Raman scattering provides stable narrow-banded signals that potentially allow for multicolor microscopic imaging. The major obstacle for the applications of Raman spectroscopy and microscopy is the small cross section of Raman scattering that results in low sensitivity. Here, we report a new concept of azo-enhanced Raman scattering (AERS) by designing the intrinsic molecular structures using resonance Raman and concomitant fluorescence quenching strategies. Based on the selection of vibrational modes and the enhancing unit of azobenzenes, we obtained a library of AERS molecules with specific Raman signals in the fingerprint and silent frequency regions. The spectral characterization and molecular simulation revealed that the azobenzene unit conjugated to the vibrational modes significantly enhanced Raman signals due to the mechanism of extending the conjugation system, coupling the electronic–vibrational transitions, and improving the symmetry of vibrational modes. The nonradiative decay of azobenzene from the excited state quenched the commitment fluorescence, thus providing a clean background for identifying Raman scattering. The most sensitive AERS molecules produced Raman signals of more than 4 orders of magnitude compared to 5-ethynyl-2′-deoxyuridine (EdU). In addition, a frequency tunability of 10 distinct Raman bands was achieved by selecting different types of vibrational modes. This methodology of AERS allows for designing small-molecule Raman probes to visualize various entities in complex systems by multicolor spontaneous Raman imaging. It will open new prospects to explore innovative applications of AERS in interdisciplinary research fields.

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Super-capacity information-carrying systems encoded with spontaneous Raman scattering

Abstract: Super-capacity information-carrying systems are fabricated by tuning vibrational signals into octal numeral intensities in multiple bands of Raman-silent regions.

Cited by 28 publications

References 34 publications

Precise Encoding of Triple‐Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application

Precise Encoding of Triple‐Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application

Organic micro/nanoscale materials for photonic barcodes

Azo-Enhanced Raman Scattering for Enhancing the Sensitivity and Tuning the Frequency of Molecular Vibrations

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