<sup>19</sup>F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

Tirotta, Ilaria; Dichiarante, Valentina; Pigliacelli, Claudia; Cavallo, Gabriella; Terraneo, Giancarlo; Bombelli, Francesca Baldelli; Metrangolo, Pierangelo; Resnati, Giuseppe

doi:10.1021/cr500286d

Cited by 433 publications

(483 citation statements)

References 174 publications

(390 reference statements)

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“…44 The application of 19 F NMR probes for the monitoring of biological events and reactions has been well known as a valid strategy for obtaining detailed information at deep spots inside vital bodies. [45][46][47][48][49][50][51] To date, although various types of molecular probes and detection systems have been manufactured for evaluating biological events and alteration of environmental factors, the monitoring of the bioreactions with 19 F NMR probes commonly suffers from an intrinsically low sensitivity in 19 F NMR measurements. Therefore, it was difficult to monitor slight amounts of bio-active molecules.…”

Section: Poss Element-blocks For Realizing Designable Hybridsmentioning

confidence: 99%

Recent progress in the development of advanced element-block materials

Gon

Tanaka

Chujo

2017

Polym J

135

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An element-block is defined as a minimum functional unit composed of heteroatoms. The concept of 'element-block material' for designing advanced materials was proposed in 2015. In this review, the recent progress in material designs based on this concept is described. From our research, several element-blocks as representative examples are selected, and their roles in each material are explained. Initially, research on the development of 'designable hybrids' by employing polyhedral oligomeric silsesquioxane (POSS) is illustrated. Multiple functions of hybrids composed of modified POSS and the significant roles of POSS in bio-related polymeric materials for solving critical problems in conventional 19 F MR probes and for realizing new sensing technologies are demonstrated. Next, solid-state luminescent materials containing o-carborane and group 13 element-blocks are discussed. The materials' highly efficient emission in the solid state and their origins are explained. Furthermore, stimuliresponsive luminescent chromism is summarized. The sensing mechanisms and the application of these materials as sensors are presented in this study. In the last part, we mention optically active element-blocks containing chiral P-stereogenic phosphorus. In this review, the characteristics originating from each element-block are explained.

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Section: Poss Element-blocks For Realizing Designable Hybridsmentioning

confidence: 99%

Recent progress in the development of advanced element-block materials

Gon

Tanaka

Chujo

2017

Polym J

135

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“…This could further increase the specificity and accuracy of MRI-based tumor detection [32]. [34,35]. Also of importance is that 19 F has the potential to offer quantitative MRI.…”

Section: Chemical Exchange Saturation Transfer (Cest) For Mrimentioning

confidence: 99%

Dendrimer-based magnetic resonance imaging agents for brain cancer

et al. 2018

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Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imaging for tumor localization and delineation. Thanks to advances in bioimaging, brain cancer can be detected earlier and resected more reliably. Magnetic resonance imaging (MRI) is the most common and preferred method to delineate brain cancer, and a contrast agent is often required to enhance imaging contrast. Dendrimers, a special family of synthetic macromolecules, constitute a particularly appealing platform for constructing MRI contrast agents by virtue of their well-defined three-dimensional structure, tunable nanosize and abundant surface terminals, which allow the accommodation of high payloads and numerous functionalities. Tuning the dendrimer size, branching and surface composition in conjunction with conjugation of MRI functionalities and targeting moieties can alter the relaxivity for MRI, overcome the blood-brain barrier and enhance tumor-specific targeting, hence improving the imaging quality and safety profile for precise and accurate imaging of brain tumors. This short review highlights the recent progress, opportunities and challenges in developing dendrimer-based MRI contrast agents for brain tumor imaging.

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“…Instead of providing only anatomical information, 19 F MRI exhibits great potential in developing quantitative MRI. [8][9][10][11] However, in most reported 19 F MRI studies, the application of 19 F MRI is restricted due to the lack of suitable imaging agents and the shortcomings of existing 19 F imaging agents (including perfluorocarbon emulsions). Agents' instability, the splitting 19 F signal, complex formulation procedure, and excessive retention in organs should not be neglected.…”

Section: Doi: 101002/adma201601064mentioning

confidence: 99%

Superfluorinated PEI Derivative Coupled with ^99mTc for ASGPR Targeted ¹⁹F MRI/SPECT/PA Tri‐Modality Imaging

et al. 2016

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Fluorinated polyethylenimine derivative labeled with radionuclide (99m) Tc is developed as a (19) F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)-targeting ability. This multifunctional agent is safe and suitable for (19) F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.

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¹⁹F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

Cited by 433 publications

References 174 publications

Recent progress in the development of advanced element-block materials

Recent progress in the development of advanced element-block materials

Dendrimer-based magnetic resonance imaging agents for brain cancer

Superfluorinated PEI Derivative Coupled with ^99mTc for ASGPR Targeted ¹⁹F MRI/SPECT/PA Tri‐Modality Imaging

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19F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

Cited by 433 publications

References 174 publications

Recent progress in the development of advanced element-block materials

Recent progress in the development of advanced element-block materials

Dendrimer-based magnetic resonance imaging agents for brain cancer

Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri‐Modality Imaging

Contact Info

Product

Resources

About

¹⁹F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

Superfluorinated PEI Derivative Coupled with ^99mTc for ASGPR Targeted ¹⁹F MRI/SPECT/PA Tri‐Modality Imaging