Sunscreen Effects on UV-Induced Immune Suppression

Ullrich, Stephen E.; Kim, Tae Heung; Ananthaswamy, Honnavara N.; Kripke, Margaret L.

doi:10.1038/sj.jidsp.5640184

Cited by 29 publications

(21 citation statements)

References 16 publications

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“…However, it has been shown that both DNA damage and immunosuppression are induced by UVR at the suberythema doses (7). It has also been demonstrated that some UVR‐induced genetic damage and immunosuppression occur in spite of sunscreen uses (8). Therefore, development of highly effective and efficacious photopreventive products has become a top priority in the field of dermatology.…”

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confidence: 99%

Protective effects of green tea extracts on photoaging and photommunosuppression

Wei

et al. 2009

Skin Research and Technology

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Background: Health benefits of designed functional foods using dairy fermented products in co-production with medicinal herbs are under comprehensive investigations. Yoghurt has triggered a functional food revolution while green tea and Moringa oleifera represent precious source of high content of various types of antioxidants and micronutrients. Oxidative stress and lipid peroxidation are suggested mechanisms involved in lead toxicity. The aim of present study was to assess protective effects of green tea and moringa leave extracts and their bio-yoghurts against lead acetate-induced oxidative stress in male rats by following liver weight and enzymes and lipids profile.

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confidence: 99%

Protective effects of green tea extracts on photoaging and photommunosuppression

Wei

et al. 2009

Skin Research and Technology

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“…concluded that, based on the available data, sunscreens offer, at best, partial protection from UV‐induced immune suppression and that a product's immune‐protective capacity is probably less than its capacity to prevent erythema (i.e. IPF < SPF) 13 . However, most of these data were derived using sunscreens that filter mainly in the more erythemogenic UVB region (290–320 nm) and, to some extent, through the UVAII portion (320–340 nm) of the spectrum.…”

Section: Definition Of Terms and Abbreviations Commonly Used In Photomentioning

confidence: 99%

Sunscreens and immune protection

Baron

Stevens

2002

Br J Dermatol

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“…However, the most popular fluorescent sunlamp used in photoimmunology, the FS40, contains both short-wave UVB and UVC (4). The use of a cellulose acetate filter (Kodacelfilter) to block short-wave UV below 290 nm (4) can avoid this problem, but even with Kodacel-filtered FS40 sunlamps, there remains sufficient amounts of short-wave, highly potent immune-suppressing UV below 295-300 nm (Fig.…”

Section: Controversies Concerning Sunscreen Protectionmentioning

confidence: 99%

“…The ability of a sunscreen to protect against erythema, the so-called SPF, although well characterized may not be an adequate measure of a sunscreen's ability to protect against other biological endpoints, particularly immune suppression (4). Although there are many examples in the scientific literature regarding sunscreen protection against UV-in-…”

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confidence: 99%

UV‐induced immune suppression and sunscreen

Gil

Kim

2000

Photoderm Photoimm Photomed

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Sun protection factor (SPF) that measures sunscreen protection against erythema and edema may not be enough to measure a sunscreen's activity against many other biologic reactions induced by ultraviolet radiation (UV). It may be better to evaluate sunscreen efficacy using various tools including immune protection factor (IPF), mutation protection factor (MPF) and protection against photocarcinogenesis. In terms of immune protection, sunscreens protected against UV-induced immune suppression significantly. But protection in some cases was partial and often the IPF of sunscreens were less than the SPF. IPF may differ with various immunological endpoints, and it T he sun emits a wide range of ultraviolet (UV) radiation. All of the harmful UVC (200-280 nm) and most of UVB (280-320 nm) is absorbed by the stratospheric ozone layer. Stratospheric ozone does not affect UVA (320-400 nm) transmission. As the stratospheric ozone layer is depleted (1) the amount of harmful shortwave UV reaching the earth's surface will increase. On the other hand, chances of UV exposure by increased outdoor activity and imprudent use of sun tanning machines increased the risks of unwanted UV effects, such as sunburn, photoaging, skin cancer induction and immune suppression (2). Solar UV is the most prominent cause of skin cancer, a cancer that is the most common cancer found in Caucasian populations. During photocarcinogenesis, UV works as both an initiator by directly damaging DNA and as a promotor by suppressing immunologic rejection (3).Sunscreen use has been promoted as one way to prevent these harmful consequences of UV exposure. The ability of a sunscreen to protect against erythema, the so-called SPF, although well characterized may not be an adequate measure of a sunscreen's ability to protect against other biological endpoints, particularly immune suppression (4). Although there are many examples in the scientific literature regarding sunscreen protection against UV-in-101 may be better to use a couple of different assays to measure sunscreen protection more objectively. Sunscreen use protects against most UV-induced nonmelanoma skin cancers and actinic keratoses but its activity against melanoma is not clear. More studies with broad-spectrum stable sunscreens and better models for the investigation of malignant melanoma are required.

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Sunscreen Effects on UV-Induced Immune Suppression

Cited by 29 publications

References 16 publications

Protective effects of green tea extracts on photoaging and photommunosuppression

Protective effects of green tea extracts on photoaging and photommunosuppression

Sunscreens and immune protection

UV‐induced immune suppression and sunscreen

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