Sun‐induced changes of stratum corneum hydration vary with age and gender in a normal Chinese population

Liu, Zhi‐Li; Shu-min, Song; Luo, Wei; Elias, Peter M.; Man, Mao‐Qiang

doi:10.1111/j.1600-0846.2011.00536.x

Cited by 22 publications

(24 citation statements)

References 48 publications

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“…These localization-dependent differences are probably influenced by the higher sun exposure of the face and neck. This presumption was confirmed by Liu et al [31], who showed that cumulative sun exposure does reduce SC hydration, probably due to a UVB-induced downregulation of epidermal ceramides, fillagrins and aquaporins [32,33,34,35]. …”

Section: Discussionsupporting

confidence: 68%

Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects

Luebberding

Krueger

Kerscher

2013

Skin Pharmacol Physiol

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Background/Purpose: Modern men have changed their beauty and grooming habits, which has resulted in an increasing demand for cosmetics for men. However, very little information is available about the dermatological needs of male skin. Therefore, the aim of this present clinical study was to conduct the first systematic assessment of the skin physiology of men with special attention to lifetime changes. Methods: A total of 150 healthy male subjects (aged 20-70 years) were selected following strict criteria, including age, sun behavior and smoking habits. Transepidermal water loss (TEWL), hydration level, sebum production and pH values were measured with worldwide-acknowledged biophysical measuring methods at the forehead, cheek, neck, volar forearm and dorsum of hand. Results: TEWL and sebum production vary by localization, but generally not with increasing age, whereas stratum corneum (SC) hydration decreases significantly at the face and neck. The greatest decrease was assessed at the forehead. Skin surface pH significantly increases with aging in the face. Conclusion: The present study assigns for the first time systematic reference values for standardized biophysical measuring methods and localizations reflecting the skin physiology of men in relation to age. The results show that the physiology of male skin partly changes with aging. While SC hydration and skin surface pH are affected by the subject's age, TEWL and sebum production show only minor variations.

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Section: Discussionsupporting

confidence: 68%

Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects

Luebberding

Krueger

Kerscher

2013

Skin Pharmacol Physiol

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“…HA is known to play a key role in maintaining the water content of the skin. Previous reports have described an age‐related variation in hydration levels between the SC and dermis . We observed an age‐related difference in the hydration patterns between the epidermal and dermal layers of skin.…”

Section: Discussionsupporting

confidence: 52%

Age‐related biophysical changes of the epidermal and dermal skin in Korean women

Cho

Cho²,

Kim³

et al. 2019

Skin Research and Technology

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Introduction The clinical characteristics of skin were investigated to study the inter‐relationship and changes in the biophysical properties of the epidermal and dermal layers associated with aging using noninvasive methods. Methods Our study included 100 healthy women aged between the early 20s and late 60s. Biophysical characteristics of skin such as color (brightness and spots), transparency, wrinkle on crow's feet, elasticity, hydration, sebum content, glossiness, and transepidermal water loss measured under controlled conditions. Results This study performed in a Korean population demonstrated that aging significantly affects human skin in terms of parameters such as wrinkles, skin color, elasticity, and epidermal hydration. Age‐related changes in skin hydration showed varying patterns between the epidermis and dermis. Skin color showed heterogeneous characteristics between the upper and lower epidermal layers associated with aging. Skin elasticity and wrinkles were observed to show and inversely proportional relationship in the early 40s. Conclusions We confirmed the significant influence of aging on the biophysical properties of skin and determined the distinct age‐related biophysical changes in the epidermal and dermal layers of skin using noninvasive method. This study indicates the need for further research to investigate the distinctive age‐related changes in characteristics of the epidermal and dermal layers of human skin.

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“…Thus, keratinocytes derived from different sites can serve as general keratinocyte model systems. Taken together, the results on primary keratinocytes were counterintuitive considering constitutional factors on the one hand and studies that have demonstrated varying skin functions (15)(16)(17)(18)(19)(20) on the other hand. Our results suggest that involvement of keratinocytes is only small in skin functions dependent on age, gender, or localization and that their main function comprises formation of a barrier against environmental insults.…”

Section: A431 Cells Exhibit Decrease In Stromal Communication Increamentioning

confidence: 66%

“…However, the short keratinocyte life cycle of about 4 weeks requires a steady supply of fresh tissue samples, and a concern is that varying constitutional factors such as age, gender, and anatomic site may compromise experimental results. Many skin properties have been examined with respect to such factors and an impact has been observed on epidermal thickness (15), epidermal nerve fiber density (16), skin surface pH (17), protein absorption ability (18), stratum corneum hydration (17,19), melanin index, and skin elasticity (20). These properties arise from the interplay of many cell types in the tissue context, most importantly between dermal fibroblasts and epidermal keratinocytes.…”

mentioning

confidence: 99%

Consistency of the Proteome in Primary Human Keratinocytes With Respect to Gender, Age, and Skin Localization

Sprenger

Weber

Zarai

et al. 2013

Molecular & Cellular Proteomics

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Keratinocytes account for 95% of all cells of the epidermis, the stratified squamous epithelium forming the outer layer of the skin, in which a significant number of skin diseases takes root. Immortalized keratinocyte cell lines are often used as research model systems providing standardized, reproducible, and homogenous biological material. Apart from that, primary human keratinocytes are frequently used for medical studies because the skin provides an important route for drug administration and is readily accessible for biopsies. However, comparability of these cell systems is not known. Cell lines may undergo phenotypic shifts and may differ from the in vivo situation in important aspects. Primary cells, on the other hand, may vary in biological functions depending on gender and age of the donor and localization of the biopsy specimen. Here we employed metabolic labeling in combination with quantitative mass spectrometry-based proteomics to assess A431 and HaCaT cell lines for their suitability as model systems. Compared with cell lines, comprehensive profiling of the primary human keratinocyte proteome with respect to gender, age, and skin localization identified an unexpected high proteomic consistency. The data were analyzed by an improved ontology enrichment analysis workflow designed for the study of global proteomics experiments. It enables a quick, comprehensive and unbiased overview of altered biological phenomena and links experimental data to literature. We guide through our workflow, point out its advantages compared with other methods and apply it to visualize differences of cell lines compared with primary human keratinocytes. Molecular &

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Sun‐induced changes of stratum corneum hydration vary with age and gender in a normal Chinese population

Abstract: These results demonstrated that sun-induced changes of the SC hydration property vary with age and gender.

Cited by 22 publications

References 48 publications

Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects

Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects

Age‐related biophysical changes of the epidermal and dermal skin in Korean women

Consistency of the Proteome in Primary Human Keratinocytes With Respect to Gender, Age, and Skin Localization

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