SUN-422 Risk Factors Associated with Thyroid Nodules in Type 2 Diabetes

Abstract

Objective: To determine risk factors associated with the presence of thyroid nodules in patients with type 2 diabetes Material and methods: A case control prospective study, matched 1:1, according to age, sex and smoking habit was conducted. Patients with type 2 diabetes were recruited from the Endocrinology Service of Cayetano Heredia Hospital, Lima-Perú. Clinical evaluation, laboratory tests and thyroid ultrasound were performed to indentify patients with type 2 diabetes with and without thyroid nodules. The association was evaluated by calculating Odds ratios (OR) by conditional multivariate logistic regression techniques. Results: 83 patients with type 2 diabetes and thyroid nodule and 83 patients with type 2 diabetes without thyroid nodule; were obtained. The risk factors associated with the presence of thyroid nodules in patients with type 2 diabetes were HbA1c (OR= 4.12, P= 0.002), BMI (OR= 1.13, P 0.030) and TSH (OR= 3.27, P= 0.0001), with cut-off points according to ROC curve of HbA1c ≥ 8%, TSH in the normal upper limit ≥ 2.3 μIU / mL and BMI ≥ 27 kg / m2. Patients with type 2 diabetes and thyroid nodule had higher values of blood glucose, thyroid volume, abdominal and neck circumference; greater frequency of acantosis nigricans and acrochordons compared to controls. Conclusions: The risk factors associated with the presence of thyroid nodules in patients with type 2 diabetes were HbA1c, BMI and TSH, with cut-off points according to ROC curve of HbA1c ≥ 8%, TSH in the normal upper limit ≥ 2.3 μIU / mL and BMI ≥ 27 kg / m2.