Summary of the 2008 BTS/SIGN British Guideline on the Management of Asthma

Levy, Mark L; Thomas, Mike; Small, Iain; Pearce, Linda; Pinnock, Hilary; Stephenson, Paul

doi:10.3132/pcrj.2008.00067

Cited by 64 publications

(55 citation statements)

References 68 publications

(57 reference statements)

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“…Studies on asthma patients that are sensitized to house dust mite and/or pets, show limited evidence of clinical benefit for asthma with multi-component avoidance and there are no validated methods for identifying those who are likely to benefit [103]. However, in subjects with symptomatic allergy, allergen specific avoidance should be considered if feasible (e.g.…”

Section: Management Of Severe Asthmamentioning

confidence: 99%

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Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma (‘difficult asthma’) should undergo systematic assessment, in order to differentiate between true severe asthma, and ‘difficult-to-treat’ patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

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Section: Management Of Severe Asthmamentioning

confidence: 99%

“…Unfortunately only a minority of subjects considered having severe asthma have been systematically assessed [9]. There are no studies formally assessing the best way to organize the management of severe asthma, but based on current understanding and recommendations by other societies [103] we recommend the following.…”

Section: Management Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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“…FEV1%pred < 70%), in order to verify the diagnosis of asthma. A significant reversibility was defined as a 12% increase in FEV 1 (and minimum 250 mL) 15 min after 4 puffs of terbutaline [14]. …”

Section: Assessmentmentioning

confidence: 99%

Feasibility of high-intensity training in asthma

Toennesen

Soerensen

Hostrup

et al. 2018

European Clinical Respiratory Journal

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Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial ‘EFFORT Asthma’ explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients’ pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2max). Design: We used data from the EFFORT Asthma Study. Of the 36 patients randomized to the 8-week exercise intervention consisting of high-intensity training three times per week, 29 patients (45% females) completed the study and were included in this data analysis. Pre-intervention assessment included the asthma control questionnaire (ACQ), spirometry, fractional exhaled nitric oxide (FeNO) and AHR to mannitol. VO2 max was measured during an incremental cycle test. Results: The majority of included patients had partly or uncontrolled asthma reflected by a mean (SD) ACQ at 1.7 (0.6). Median (IQR) FeNO was 28.5 (23.8) ppb and 75% had a positive mannitol test indicating AHR.The association between patients’ training response measured as increase in VO2max and pre-intervention ACQ scores was not statistically significant (p = 0.49). Likewise, the association between patients’ increase in VO2max and FeNO as well as AHR was not statistically significant (p = 0.80 and p = 0.58). Conclusions: Included asthma patients could adhere to the high-intensity interval protocol and improve their VO2max regardless of pre-intervention levels of asthma control, airway inflammation and AHR.

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“…Hierfür ist manchmal eine O 2 -Insufflation über Maske mit hohem "flow" erforderlich. [298,307]. Die Verneblung von Adrenalin bietet keinen zusätz-lichen Vorteil zur Anwendung von vernebelten β 2 -Agonisten während des akuten Asthmaanfalls [308].…”

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