Summary of ongoing clinical protocols for proton and heavier-ion therapy

Giap, Fantine; Levy, Richard P.; Giap, Huan

doi:10.1063/1.4802347

Cited by 2 publications

(3 citation statements)

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“…However, GR and ion beam irradiation have different energy deposition modes [6]. Heavy ion beams could densely deposit their energy [7], while GRs sparsely deposit their energy in a large target volume [8] so that the linear energy transfer (LET) of GRs is significantly lower than that of ion beams [9,10]. High-energy heavy ion beams are a type of ion beam that has a higher linear energy transfer and, therefore, higher relative biological effectiveness (RBE) and a wider mutational spectrum [11].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Effect of High-Energy Heavy Ion Beam on Rice Genome: Transposon Activation

Wen,

Li,

Yang

et al. 2023

Genes

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High-energy heavy ion beams are a new type of physical mutagen that can produce a wide range of phenotypic variations. In order to understand the mechanism of high-energy heavy ion beams, we resequenced the whole genome of individual plants with obvious phenotypic variations in rice. The sequence alignment results revealed a large number of SNPs and InDels, as well as genetic variations related to grain type and heading date. The distribution of SNP and InDel on chromosomes is random, but they often occur in the up/downstream regions and the intergenic region. Mutagenesis can cause changes in transposons such as Dasheng, mPing, Osr13 and RIRE2, affecting the stability of the genome. This study obtained the major gene mutation types, discovered differentially active transposons, screened out gene variants related to phenotype, and explored the mechanism of high-energy heavy ion beam radiation on rice genes.

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Section: Introductionmentioning

confidence: 99%

Exploring the Effect of High-Energy Heavy Ion Beam on Rice Genome: Transposon Activation

Wen,

Li,

Yang

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

“…After Bragg peak property of an ion beam was found to be better than the conventional photon beam in curing patients with tumor, first clinical experience on a human being with a proton beam was reported by researchers in University of California, Berkeley in 1954 [2].…”

Section: Introductionmentioning

confidence: 99%

“…In 1990, the world first hospital-based proton therapy facility was constructed in Loma Linda, USA [2]. So far there are about forty operating proton facilities worldwide and the total number of patients treated by particle beam therapy exceeded 100,000 [2].…”

Section: Introductionmentioning

confidence: 99%