Sumac-rose water mouthwash versus benzydamine to prevent radiation-induced oral mucositis in head and neck cancers: a phase II randomized trial

Ameri, Ali; Heydarirad, Ghazaleh; Choopani, Rasoul; Poshtmahi, Sanaz; Ameri, Pooya; Talebi, Fereshteh; Pour, Anahid Bagheri; Taghizadeh‐Hesary, Farzad

doi:10.1007/s00432-023-04687-1

Cited by 5 publications

(1 citation statement)

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“…This paradigm has two problems: tumors are generally heterogeneous with different genetic and epigenetic signatures, and tumor hosts vary in racial, ethnic, and genetic features, which might affect the treatment outcomes [ 5 ]. Emerging evidence reflects the importance of patient characteristics, including age, gender, ethnicity, comorbidities, lifestyle, and intrinsic characteristics of cancer on treatment response [ 6 , 7 , 8 ]. This strategy has become a discipline in oncology called Personalized Cancer Treatment .…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Metabolism: A New Dimension of Personalized Oncology

Behnam

Taghizadeh‐Hesary

2023

Cancers

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Energy is needed by cancer cells to stay alive and communicate with their surroundings. The primary organelles for cellular metabolism and energy synthesis are mitochondria. Researchers recently proved that cancer cells can steal immune cells’ mitochondria using nanoscale tubes. This finding demonstrates the dependence of cancer cells on normal cells for their living and function. It also denotes the importance of mitochondria in cancer cells’ biology. Emerging evidence has demonstrated how mitochondria are essential for cancer cells to survive in the harsh tumor microenvironments, evade the immune system, obtain more aggressive features, and resist treatments. For instance, functional mitochondria can improve cancer resistance against radiotherapy by scavenging the released reactive oxygen species. Therefore, targeting mitochondria can potentially enhance oncological outcomes, according to this notion. The tumors’ responses to anticancer treatments vary, ranging from a complete response to even cancer progression during treatment. Therefore, personalized cancer treatment is of crucial importance. So far, personalized cancer treatment has been based on genomic analysis. Evidence shows that tumors with high mitochondrial content are more resistant to treatment. This paper illustrates how mitochondrial metabolism can participate in cancer resistance to chemotherapy, immunotherapy, and radiotherapy. Pretreatment evaluation of mitochondrial metabolism can provide additional information to genomic analysis and can help to improve personalized oncological treatments. This article outlines the importance of mitochondrial metabolism in cancer biology and personalized treatments.

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