Sumac as a novel adjunctive treatment in hypertension: a randomized, double-blind, placebo-controlled clinical trial

Ardalani, Hamidreza; Moghadam, Maryam Hassanpour; Rahimi, Roja; Soltani, Jalal; Mozayanimonfared, Azadeh; Moradi, Mehdi; Azizi, Ali

doi:10.1039/c5ra22840a

Cited by 40 publications

(24 citation statements)

References 32 publications

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“…The biochemical biomarkers were adjusted for mean change of energy intake and physical activity (Table 5). (Ardakani, Vahidi, Karimi-Nazari, Dehghani, & Nadjarzadeh, 2016;Ardalani et al, 2016;Asgary et al, 2018;Heydari et al, 2019;Jaradat et al, 2017). In accordance with this study, the beneficial effects of sumac on weight and BMI were previously observed among hyperlipidemic obese (Asgary et al, 2018) and overweight or obese individuals (Heydari et al, 2019).…”

Section: Effects On Biochemical Assessmentssupporting

confidence: 86%

“…To our knowledge, this study is the first to evaluate the effects of sumac supplementation in combination with RCD on obesity and depression and to show some of its effects on a number of physiological pathways that are disturbed in obesity and mental health disorders. However, some in vitro study and clinical trials have investigated the effects of sumac on anthropometric indices in other metabolic disorders (Ardakani, Vahidi, Karimi‐Nazari, Dehghani, & Nadjarzadeh, 2016; Ardalani et al, 2016; Asgary et al, 2018; Heydari et al, 2019; Jaradat et al, 2017). In accordance with this study, the beneficial effects of sumac on weight and BMI were previously observed among hyperlipidemic obese (Asgary et al, 2018) and overweight or obese individuals (Heydari et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

Hariri

Ghahroudi

Jahangiri³

et al. 2020

Phytotherapy Research

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Background: Oxidative stress and inflammation play pivotal roles in the pathophysiology of obesity and depression. This study aimed to evaluate the effects of sumac (Rhus coriaria L.) on anthropometric indices, oxidative stress, inflammation, and depression in overweight or obese depressed women. Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted on overweight or obese women aged 20-65 years with mild to moderate depression. The participants (n = 62) were assigned to receive a restricted calorie diet (RCD) plus 3 g/day of either sumac or placebo for 12 weeks. Anthropometric measurements, biochemical biomarkers, and the Beck depression inventory were assessed during the study. Results: Sumac significantly reduced weight, body mass index, body fat (p < .001), visceral fat level (p = .03), waist and hip circumference, and malondialdehyde levels (p = .03, p = .002, and p = .006, respectively) in comparison with the placebo group. The levels of interleukin-6 and tumor necrosis factor-α decreased only in the sumac group (11 and 32%, respectively); however, these reductions were not significant. The high-sensitivity c-reactive protein levels (p = .007 and p = .01, respectively) and Beck scores (p < .001) decreased significantly in both the sumac and the placebo group without any significant difference between the two groups. Conclusion: Sumac can be considered as a functional food that along with RCD could have beneficial effects on obesity management, through the possible modulatory effects on oxidative stress in overweight or obese depressed women.

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Section: Effects On Biochemical Assessmentssupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

Hariri

Ghahroudi

Jahangiri³

et al. 2020

Phytotherapy Research

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“…Furthermore, antihypertensive activity of Rhus coriaria fruits could be attributed to flavonoids, which are the main chemical constituents of this plant, demonstrating the powerful cardiovascular protective activity of these compounds (Ardalani et al. 2016 ).…”

Section: Discussionmentioning

confidence: 99%

The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet

Bogavac-Stanojević

Stevuljević

Černe

et al. 2018

Pharmaceutical Biology

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Context: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage.Objectives: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)].Materials and methods: Eighteen male Wistar albino rats were divided into three groups (n = 6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin.Results: Normalized HO-1 [0.11 (0.04–0.24)] and MCP-1 [0.29 (0.21–0.47)] mRNA levels and DNA scores [12.50 (4.50–36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35–2.51)], p = 0.021 for HO-1 [0.85 (0.61–3.45)], p = 0.047 for MCP-1 and [176.5 (66.50–221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21–0.71), p = 0.049].Conclusions: Supplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage.

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“…In two studies, on two plants, chia (Nieman et al, 2009) and Rhus coriaria L. (Ardalani et al, 2016), it has been shown that they can increase the level of insulin secretion (Figure 2).…”

Section: Effect Of Herbal Medicines On Glycemic Indicesmentioning

confidence: 99%

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Payab

Hasani‐Ranjbar

Shahbal

et al. 2019

Phytotherapy Research

100

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Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards of Reporting Trials checklist. The main outcomes were anthropometric indices and metabolic syndrome components. Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI). A total of 279 relevant clinical trials were included. Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome. In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite. Meta‐analysis showed that intake of green tea resulted in a significant improvement in weight ([SMD]: −0.75 [−1.18, −0.319]), body mass index ([SMD]: −1.2 [−1.82, −0.57]), waist circumference ([SMD]: −1.71 [−2.66, −0.77]), hip circumference ([SMD]: −0.42 [−1.02, −0.19]), and total cholesterol, ([SMD]: −0.43 [−0.77, −0.09]). In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: −0.88, 95 % CI: [−1.13, −0.63]) and triglyceride ([SMD]: −1.67, 95 % CI: [−2.54, −0.79]), respectively. High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome.

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Sumac as a novel adjunctive treatment in hypertension: a randomized, double-blind, placebo-controlled clinical trial

Abstract: Sumac; a novel adjunctive treatment in Blood Pressure.

Cited by 40 publications

References 32 publications

The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

The beneficial effects of sumac (Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

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