Sulphapyridine in Ophthalmia Neonatorum

The Sulphonamides in Ophthalmia Neonatorum

“…(White Oak (L.C.C. ) Hospital) In an earlier communication (Sorsby, Hoffa, and Smellie, 1942) an account was given of the value of the administration of sulphapyridine in 273 cases of ophthalmia neonatorum treated at White Oak Hospital from towards the end of 1939 till Dec. 31, 1941.…”

Optimal Methods in the Treatment of Ophthalmia Neonatorum

“…When sulphonamides were first used in the treatment of ophthalmia neonatorum a dose of 0.125 g. initially and 0.062 g. at six-hourly intervals was given (Sorsby, Hoffa, and Smellie, 1942). Subsequently the maintenance dose was raised to 0.083 g. With these doses the incidence of unsatisfactory response and relapse was 38.1 %.…”

“…The relative value of sulphanilamide, sulphapyridine, sulphamezathine, sulphathiazole, and sulphadiazine in the treatment of ophthalmia neonatorum has been discussed in a previous study (Sorsby, 1945). It was pointed out that, with the dose of 0.25 g. on admission and 0.125 g. fourhourly day and night until 48 hours after clinical cure, the results obtained by different sulphonamides were essentially the same, and that sulphanilamide itself and sulphapyridine were less desirable than sulphamezathine and sulphathiazole and sulphadiazine, as they tended to give toxic symptoms rather more frequently.…”

“…The different modes of using penicillin were found to give a high rate of adequate results only when penicillin locally was applied in high concentration and at frequent intervals (Sorsby, 1947). In a series of 104 cases treated initially at intervals of one minute for half an hour (with drops in a concentration of 2,500 units per ml.…”