Sulfuric Acid Aerosol Followed by Ozone Exposure in Healthy and Asthmatic Subjects

Frampton, Mark W.; Morrow, Paul E.; C, Cox; Levy, Paul C.; Condemi, John J.; Speers, Donna M.; Gibb, F.R.; Utell, Mark J.

doi:10.1006/enrs.1995.1020

Cited by 23 publications

(11 citation statements)

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“…Acute respiratory morbidity was reported to be most highly correlated with ambient air sulfate levels rather than levels of fine, inhalable, or total suspended particulates (Ostro, 1990). Some controlled exposure studies indicate that asthmatics are more sensitive to H 2 SO 4 aerosols than healthy individuals, who are generally nonresponsive (Koenig et al, 1983;Utell et al, 1983;Linn et al, 1989), although other studies do not find increased sensitivity in asthmatics (Avol et al, 1979;Aris et al, 1991;Frampton et al, 1995). In animal studies, chronic exposure of rabbits to H 2 SO 4 increased airway responsiveness to acetylcholine challenge (Gearhart and Schlesinger, 1986).…”

Section: Discussionmentioning

confidence: 94%

Metal and Sulfate Composition of Residual Oil Fly Ash Determines Airway Hyperreactivity and Lung Injury in Rats

Gavett

Madison

Dreher

et al. 1997

Environmental Research

144

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Section: Discussionmentioning

confidence: 94%

Metal and Sulfate Composition of Residual Oil Fly Ash Determines Airway Hyperreactivity and Lung Injury in Rats

Gavett

Madison

Dreher

et al. 1997

Environmental Research

144

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“…From a controlled exposure study (214) in healthy and allergic asthmatic nonsmokers there is evidence of lung function decrements after 3 hrs of exposure to either 100 µg/m 3 of H 2 SO 4 or NaCl (control) aerosol followed by 360 µg/m 3 (180 ppb) of O 3 , with greater decrements for those exposed to H 2 SO 4. Repeated daily, short term exposures of healthy and mildly asthmatic subjects to O 3 attenuates the acute lung function and, to a less extent the inflammatory response, reaching a maximum over 3 to 5 days and with a recovery over four to seven days after the end of the exposure (215,216,217,218,219,220).…”

Section: Rationalementioning

confidence: 99%

Comparative Health Impact Assessment of Local and Regional Particulate Air Pollutants in Scandinavia

Forsberg¹,

Hansson²,

Johansson³

et al. 2005

AMBIO: A Journal of the Human Environment

100

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Detailed knowledge on the effects of air pollutants on human health is a prerequisite for the development of effective policies to reduce the adverse impact of ambient air pollution. The second edition of WHO's Air quality guidelines (AQG) for Europe, formulated in 1996, summarizes systematically the effects of several air pollutants. These guidelines have been used extensively to establish regulatory frameworks for air quality assessment and management. To support the development of European Union policy on clean air for Europe (CAFÉ), this WHO Working Group (WG) was convened to review systematically the most recent scientific evidence on the adverse health effects of particulate matter (PM), ozone (O 3 ) and nitrogen dioxide (NO 2 ). The review focused on studies that were published after the second edition of the WHO AQG was produced, and which have been influential in changing our views on health-related aspects of the substances under consideration. The WG adopted a recommendation to use fine particulate matter, (PM 2.5 ), as the indicator for health effects induced by particulate pollution such as increased risk of mortality in Europe, to supplement the commonly used PM 10 (which includes fine and coarse particles). It also acknowledged the evidence that ozone produces short-term effects on mortality and respiratory morbidity, even at the low ozone concentrations experienced in many cities in Europe. Based on these findings the WG recommended that WHO should update exposure-response relationships for the most severe health outcomes induced by particulate matter and ozone presented by AQGs. The WG also concluded that an update of the current WHO AQG for nitrogen dioxide, which is also an important precursor for the formation of ozone and particulate matter, was not warranted. Keywords OZONE -adverse effects NITROGEN DIOXIDE -adverse effects AIR POLLUTANTS, ENVIRONMENTAL -adverse effects META-ANALYSIS AIR -standards GUIDELINES © World Health Organization -2003All rights in this document are reserved by the WHO Regional Office for Europe. The document may nevertheless be freely reviewed, abstracted, reproduced or translated into any other language (but not for sale or for use in conjunction with commercial purposes) provided that full acknowledgement is given to the source. For the use of the WHO emblem, permission must be sought from the WHO Regional Office. Any translation should include the words: The translator of this document is responsible for the accuracy of the translation. The Regional Office would appreciate receiving three copies of any translation. Any views expressed by named authors are solely the responsibility of those authors. IntroductionIn most countries in Europe, ambient air quality has improved considerably in the last few decades. However, there is a large body of evidence suggesting that exposure to air pollution, even at the levels commonly achieved nowadays in European countries, leads to adverse health effects. In particular, exposure to pollutants such as particulate mat...

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“…Moreover, risk assessment of real-life mixtures such as the simultaneous intake of food additives (92), combined exposure to fine particles and gases in ambient air (46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57), and DBPs in drinking water (77,79,80) were addressed. Attention was also drawn to strategies for estimating public health effects of large airports (81,82,86) and the development of harmonized hazard classification criteria for chemical mixtures (108,109).…”

Section: Discussionmentioning

confidence: 99%

International issues on human health effects of exposure to chemical mixtures.

Feron

Cassee

Groten

et al. 2002

Environ Health Perspect

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Sulfuric Acid Aerosol Followed by Ozone Exposure in Healthy and Asthmatic Subjects

Cited by 23 publications

References 0 publications

Metal and Sulfate Composition of Residual Oil Fly Ash Determines Airway Hyperreactivity and Lung Injury in Rats

Metal and Sulfate Composition of Residual Oil Fly Ash Determines Airway Hyperreactivity and Lung Injury in Rats

Comparative Health Impact Assessment of Local and Regional Particulate Air Pollutants in Scandinavia

International issues on human health effects of exposure to chemical mixtures.

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