International issues on human health effects of exposure to chemical mixtures.

Feron, V.J.; Cassee, Flemming R.; Groten, J.P.; Vliet, P.W. van; Zorge, J.A. van

doi:10.1289/ehp.02110s6893

Cited by 80 publications

(37 citation statements)

References 82 publications

(76 reference statements)

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“…Adverse ecological and human health effects have been observed for these organic contaminants (OCs) (Long et al, 1995;Sharpe, 2001;Feron et al, 2002;Sharpe and Irvine, 2004). It is thus of fundamental importance to determine OC concentrations in various environmental matrices which is essential for causation validation in dose-effect analysis.…”

Section: Introductionmentioning

confidence: 99%

A high throughout semi-quantification method for screening organic contaminants in river sediments

Bu¹,

Liu²,

Wang³

2014

Journal of Environmental Management

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a b s t r a c tA high throughout semi-quantification method for screening nearly 900 organic contaminants (OCs) in river sediments has been developed. For most OCs tested, concentrations calculated from the proposed semi-quantification method deviated from actual values by a factor of 4. The overall recovery tests indicated that most OCs can be successfully extracted from sediments with recovery rates from 84.1 to 128.6%. To demonstrate the effectiveness of our method towards OC quantification, we screened OCs from sediments collected from the Haihe River basin. Seventy unregulated OCs (including pesticides, flame retardants, PPCPs, etc.) were identified and quantified at concentrations up to 2600 ng/g from 24 sediment samples. From these results, it is confirmed that the developed method is a useful way to fulfill a comprehensive analysis of OCs in sediments and would be valuable for the identification and prioritization of priority pollutants in watershed management.

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Section: Introductionmentioning

confidence: 99%

A high throughout semi-quantification method for screening organic contaminants in river sediments

Bu¹,

Liu²,

Wang³

2014

Journal of Environmental Management

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“…hundreds of components (Feron et al, 2002). A number of investigations have looked into complex mixtures of VOCs to establish their ability to elicit nasal and/or ocular trigeminal chemesthesis in humans, at threshold and suprathreshold levels, among other diverse effects.…”

Section: Real World Chemical Exposures Often Involve Mixtures Of At Lmentioning

confidence: 99%

Trigeminal Chemesthesis

Cometto‐Muñiz

Simons

2015

Handbook of Olfaction and Gustation

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“…Some of these contaminants pose risks to human health and/or the environment even at extremely low concentrations [known as organic micropollutants (OMs)] (Feron et al, 2002;Long et al, 1995;Sharpe, 2001;Sharpe and Irvine, 2004). Due to the increasing sensitivity of analytical methods, the number of OMs detected in the aquatic environment is on the rise over the past decade (Schwarzenbach et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Screening for over 1000 organic micropollutants in surface water and sediments in the Liaohe River watershed

Luo

Wang

et al. 2015

Chemosphere

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h i g h l i g h t sThe reliability and usefulness of high throughout screening method was evaluated. The massive qualitative data help unveil pollution profiles among different sites. The semi-quantification results agree well with those from target analysis. The high throughout method is proven be a valuable tool in watershed management. a r t i c l e i n f o b s t r a c tHigh throughout screening method has gained attractive prospects because it offers a fast and effective approach to obtain a holistic picture of organic micropollutant (OM) pollution in a site specific environment. However, reliability and usefulness of the generated data sets for OM pollution profiles and occurrence levels have not been fully evaluated. In this paper, we screened 1030 OMs in surface water and sediments from the selected rivers of the Liaohe River watershed to (1) examine the usefulness of using qualitative data to gain insights into source identification and (2) further evaluate the reliability of the semi-quantification results in a filed study. The results showed that 81 and 89 OMs at concentrations up to 5670 ng/L and 6714 ng/g were identified in surface water and sediments, respectively. Qualitative data could be used to identify the similarity (or dissimilarity) of pollution sources at different locations for surface water, which could provide insights for source back tracking of water contamination. Accuracy tests showed that our semi-quantification results agree well with those from previously reported values and our target analysis. Though our results for the majority of newly quantified OMs need to be further confirmed, we have demonstrated that this method is suitable for understanding the pollution characteristics and occurrence levels of OMs in the environment for environmental scientists and managers.

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International issues on human health effects of exposure to chemical mixtures.

Cited by 80 publications

References 82 publications

A high throughout semi-quantification method for screening organic contaminants in river sediments

A high throughout semi-quantification method for screening organic contaminants in river sediments

Trigeminal Chemesthesis

Screening for over 1000 organic micropollutants in surface water and sediments in the Liaohe River watershed

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