Sulfur metabolism and its contribution to malignancy

Ward, Nathan P.; DeNicola, Gina M.

doi:10.1016/bs.ircmb.2019.05.001

Cited by 46 publications

(34 citation statements)

References 308 publications

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“…The disorder of metabolism is a potential hallmark of cancer. Nathan P Ward et al found that sulfur metabolism is controlled by LIAS that is required for the functions of the tricarboxylic acid (TCA) cycle, which stimulates mitochondrial oxidative metabolism and cancer progression 17,18 .…”

Section: Discussionmentioning

confidence: 99%

Identification of significant molecules and signaling pathways between 2D and 3D culture methods of renal cancer cells

Wang

Guo

et al. 2022

Preprint

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The majority of cancer studies are conducted with the two-dimensional (2D) culture method, which does not reflect tumor in vivo structure. The 3D culture method can form free bundles of cancer cells and spheroid, which mimics the tumor microenvironment in vivo. However, the molecules and signaling pathways between the 2D and 3D culture methods are still unknown. In this study, we aim to identify the key molecules and signaling pathways by analyzing the RNA-seq data. The GSE190296 was created by the BGISEQ-500 (Homo sapiens). The KEGG and GO analyses indicated sulfur compound metabolic process and regulation of leukocyte mediated immunity are the major differences between 2D and 3D renal cancer cell cultures. Moreover, we figured out several interactive genes including MYC, EGF, VEGFA, STAT3, NOTCH1, CAT, CCND1, HSPA8, DLG4, and HSPA5. Our study may provide new knowledge on the differences between 2D and 3D cancer cell cultures.

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Section: Discussionmentioning

confidence: 99%

Identification of significant molecules and signaling pathways between 2D and 3D culture methods of renal cancer cells

Wang

Guo

et al. 2022

Preprint

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“…In addition to providing sulfur required for maintaining redox reaction, the metabolism of these SAAs produces proteins with a role in maintaining the spatial structure of hair, where intermediary metabolites mediate intercellular and intracellular signaling, thus promoting epigenetic regulation of gene expression and collectively contributing to hair growth (Ward and Denicola, 2019).…”

Section: Discussionmentioning

confidence: 99%

Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat

Chai

Sun

Liu³

et al. 2021

Front. Genet.

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Sulfur, an essential mineral element for animals, mainly exists in the form of organic sulfur-containing amino acids (SAAs), such as cystine, methionine, and cysteine, within the body. The content, form, and structure of sulfur play an important role in determining the wool fiber quality. In addition, keratin-associated proteins, one of the most crucial wool fiber components, are rich in SAAs. However, sulfur metabolism from the blood to the skin and hair follicles remains unclear. In this study, we analyzed high-sulfur protein gene and sulfur metabolism genes in the cashmere goat and explored the effects of melatonin on their expression. In total, 53 high-sulfur protein genes and 321 sulfur metabolism genes were identified. We found that high-sulfur protein genes were distributed in the 3–4 and 144M regions of chromosome 1 and the 40–41M region of chromosome 19 in goats. Moreover, all year round, allele-specific expression (ASE) is higher in the 40–41M region of chromosome 19 than in the other regions. Total of 47 high-sulfur protein genes showed interaction with transcription factors and cofactors with ASE. These transcription factors and cofactors were inhibited after melatonin implantation. The network analysis revealed that melatonin may activate the sulfur metabolism process via the regulation of the genes related to cell energy metabolism and cell cycle in the skin, which provided sufficient SAAs for wool and cashmere growth. In conclusion, our findings provide a new insight into wool growth regulation by sulfur metabolism genes and high-sulfur protein genes in cashmere goats.

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“…Sulphur, remaining on the skin surface, reacts with urea, leading to the formation of ammonium sulphide, which also has antiseptic properties [26]. In addition, by binding tissue oxygen, it slows down metabolic processes and decreases the mitotic activity of cells [27].…”

Section: The Mechanism Of the Therapeutic Effect Of Radon-sulphide Watermentioning

confidence: 99%

Balneotherapy with the Use of Radon–Sulphide Water: The Mechanisms of Therapeutic Effect

2021

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Despite its enormous therapeutic potential, spa treatment is not always properly perceived, hence the numerous attempts to assess its effectiveness. In the world literature, there are few reports on therapy using sulphur- and radon-containing therapeutic waters. In countries with a long tradition of balneotherapy, activity in this field of medicine is evident. Undoubtedly, the interest in balneotherapy results also from natural resources used in spa medicine, which, as geological and balneochemical research shows, are enormous in Poland. A particular example of the occurrence of radon–sulphide waters, rare on the European scale, is the Przerzeczyn-Zdrój health resort. The mechanism of action of therapeutic waters is not fully explored, but their effectiveness in therapy is confirmed by many authors. It is believed to be an effect of combined action of many factors, the most important of which are thermal, mechanical, and chemical.

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Sulfur metabolism and its contribution to malignancy

Cited by 46 publications

References 308 publications

Identification of significant molecules and signaling pathways between 2D and 3D culture methods of renal cancer cells

Identification of significant molecules and signaling pathways between 2D and 3D culture methods of renal cancer cells

Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat

Balneotherapy with the Use of Radon–Sulphide Water: The Mechanisms of Therapeutic Effect

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