Sulfur-Mediated Polycarbonate Polyurethane for Potential Application of Blood-Contacting Materials

Abstract

In this study, a sulfur-mediated polycarbonate polyurethane (PCU-SS) is developed by mimicking the catalyzing ability of glutathione peroxidase (GPx) on nitric oxide (NO) in the human body. The PCU-SS is endowed with the capability to produce NO based on disulfide bonds, which could strongly improve the biocompatibility of the materials. The characterization results indicate that PCU-SS could not only decrease the adhesion of platelets but also enhance the capability of anti-thrombus. Moreover, it is shown that PCU-SS has a good compatibility with endothelial cells (ECs), while has a marked inhibition capacity of the proliferation of smooth muscle cells (SMCs) and macrophages (MA). Meanwhile, the result of animal implantation experiments further demonstrates the good abilities of PCU-SS on anti-inflammation, anti-thrombus, and anti-hyperplasia. Our results offer a novel strategy for the modification of blood-contacting materials based on disulfide bonds. It is expected that the PCU-SS could shed new light on biocompatibility improvement of cardiovascular stents.

In vitro comparative study of red blood cell and VWF damage on 3D printing biomaterials under different blood-contacting conditions

“…Among them, acrylic, PCISO, and Somos EvoLVe 128 are often used in medical fixtures and injection instruments while stainless steel is commonly used in body implantable devices. 14–18…”

“…Among them, acrylic, PCISO, and Somos EvoLVe 128 are often used in medical fixtures and injection instruments while stainless steel is commonly used in body implantable devices. [14][15][16][17][18] The average shear stress of the normal circulatory system in the human body is approximately 1-7 Pa. [19][20][21][22][23] To exclude the blood damage caused by supraphysiological shear stress, the two experimental platforms in this study were controlled within the range of physiological shear stress. In addition, most of the previous studies only focused on blood damage induced by materials in a static state.…”