Sulfotepp in diazinon and other organophosphorus pesticides

Turle, Richard; Levac, Barry

doi:10.1007/bf01616703

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Therefore, it may become a residue of concern during waste disposal or degradation of spilled diazinon in soil and water where hydrolysis represents a major mechanism of diazinon detoxification. Sulfotep levels ranged from <0.01 % (nondetected) to 0.53 % of diazinon in various formulations from Canada [17] and 0.3 to 0.4 % in formulated product from Brazil [20]. Sulfotep has also been detected in commercial formulations of other organophosphorus pesticides such as coumaphos, chlorpyrifos, demeton, disulfoton, fensulfothion, parathion, phosalone, and terbufos [17].…”

Section: Residue Problems Resulting From Impuritiesmentioning

confidence: 99%

Significance of impurities in the safety evaluation of crop protection products (IUPAC Technical Report)

Ambrus¹,

Hamilton²,

Kuiper³

et al. 2003

Pure and Applied Chemistry

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible. Publication of a translation into another language is subject to the additional condition of prior approval from the relevant IUPAC National Adhering Organization.

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Section: Residue Problems Resulting From Impuritiesmentioning

confidence: 99%

Significance of impurities in the safety evaluation of crop protection products (IUPAC Technical Report)

Ambrus¹,

Hamilton²,

Kuiper³

et al. 2003

Pure and Applied Chemistry

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“…1,2 Diazinon (DZN) is a thiophosphoric acid ester and a chemical substance of OP agrochemicals that were developed in 1952. 3 In crop growth, DZN has been detected as exceeding the maximum residue limit (MRL, 0.05 mg/kg) more than 11 times. 4 Due to its historical high use, the persistence of DZN in the environment is harmful as DZN is highly toxic for humans and animals as it moves through food chain.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Organophosphorothionate pesticides (OPs) are used to destroy insects, arachnids, and nematodes, and its overuse can result in various chronic neurological diseases, such as Parkinson and Alzheimer’s. , Diazinon (DZN) is a thiophosphoric acid ester and a chemical substance of OP agrochemicals that were developed in 1952 . In crop growth, DZN has been detected as exceeding the maximum residue limit (MRL, 0.05 mg/kg) more than 11 times .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and DNA Damage Caused from Diazinon Exposure by Inhibiting the PI3K-AKT Pathway in Porcine Ovarian Granulosa Cells

Wang

Luo

et al. 2018

J. Agric. Food Chem.

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Organophosphorus insecticide diazinon (DZN) is diffusely used in agriculture, home gardening, and crop peats. Much work so far has focused on the link between DZN exposure and the occurrence of neurological diseases, while little is known on the reproductive toxicological assessment on DZN exposure. This research aimed to investigate the underlying mechanisms of toxic hazards for DZN exposure on cultured porcine ovarian granulosa cells. We analyzed the oxidative stress, energy metabolism, DNA damage, apoptosis, and autophagy by using high-throughput RNA-seq, immunofluorescence, Western blotting, and real-time PCR. The combined data demonstrated that DZN exposure could cause excessive ROS and DNA damage, which induced apoptosis and autophagy by inhibiting the PI3K-AKT pathway. The down-regulated CYP19A1 protein and granulosa cell deaths increase the risk for developing premature ovarian failure and follicular atresia. In conclusion, DZN exposure has obvious reproductive toxicity by induction of granulosa cell death through pathways connected to DNA damage and oxidative stress by inhibiting the PI3K-AKT pathway.

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Degradation of pesticides diazinon and diazoxon by phosphotriesterase: insight into divergent mechanisms from QM/MM and MD simulations

Zhang

Fan

et al. 2022

Phys. Chem. Chem. Phys.

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Sulfotepp in diazinon and other organophosphorus pesticides

Cited by 4 publications

References 8 publications

Significance of impurities in the safety evaluation of crop protection products (IUPAC Technical Report)

Significance of impurities in the safety evaluation of crop protection products (IUPAC Technical Report)

Cytotoxicity and DNA Damage Caused from Diazinon Exposure by Inhibiting the PI3K-AKT Pathway in Porcine Ovarian Granulosa Cells

Degradation of pesticides diazinon and diazoxon by phosphotriesterase: insight into divergent mechanisms from QM/MM and MD simulations

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