Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects

Abstract

Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress.

Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

“…Increased water and feed intake in all the Br+TZ treatment groups can be due to adaptation of mammalian system against the TZ and broccoli extract supplementation, and broccoli extract has shown the effective preliminary response to counter the toxicity being induced by TZ. Similarly broccoli extract has been found to be antioxidant rich supplement and inducer of physiological pathways against the number of chemical substances, which ultimately tries to restores the normal metabolic activities in the living models [8,9,23,24] and these findings corroborates present investigation.…”

“…Protective antioxidative potential of large number of natural extracts have been reported, which tries to restore stress biomarkers status in vivo [9,24,25]. The amount of proteins in blood hemolysate (Table 3) and plasma (Figure 3) of all group rats was comparable.…”

Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice

“…Recent studies demonstrated that a significant increase in Desulfovibrionaceae, potential endotoxin producers, in the gut microbiomes of both HFD-induced obese mice and obese human subjects compared to lean individuals (30,31,46 In conclusion, the results of the present study indicate that glucoraphanin may be effective in preventing obesity and related metabolic disorders such as NAFLD and type 2 diabetes. A recent clinical study demonstrated that supplementation with a dietary dose of glucoraphanin (69 µmol/day) for two months significantly decreased the plasma liver enzymes, ALT and AST, although body mass did not change (18). Long-term treatment with a higher dose of glucoraphanin (800 µmol/day), which can be safely administered without any harmful side effects (17), may be required to achieve an anti-obesity effect in humans.…”

“…water extract was mixed with dextrinized cornstarch and subsequently spray-dried to yield an extract powder containing 135 mg of glucoraphanin per gram (0.31 mmol/g) (18). The total glucoraphanin titer in the resulting powder was determined by HPLC as previously reported (19).…”

Current potential health benefits of sulforaphane

“…In this present study, we reviewed the most recent studies on the biological and pharmacological activities of SFN (Table 1(Tab. 1)) (References in Table 1: Pal and Konkimalla, 2016[34]; Zhao et al, 2016[55]; Wu et al, 2016[52]; Sasaki et al, 2016[39]; Jiang et al, 2016[17]; Hernández-Rabaza et al, 2016[15]; Sikdar et al, 2016[45]; Li et al, 2016[28]; Thaler et al, 2016[48]; Lan et al, 2016[23]; Shehatou and Suddek, 2016[42]; Townsend and Johnson, 2016[49]; Qi et al, 2016[37]; Abbas et al, 2016[1]; Kikuchi et al, 2015[21]; Atwell et al, 2015[6]; Ma et al, 2015[30]; Kim et al, 2015[22]; Wang et al, 2015[50]; Lubecka-Pietruszewska et al, 2015[29]; Brown et al, 2015[7]; Carrasco-Pozo et al, 2015[8]; Ambrecht et al, 2015[3]; Lavich et al, 2015[24]; Waston et al, 2015[51]; Shirai et al, 2015[43]; Prasad and Mishra, 2015[36]; Li et al, 2015[27]; Cipolla et al, 2015[9]; Angeloni et al, 2015[5]; Oguz et al, 2015[33]; Noh et al, 2015[32]; Shang et al, 2015[41]; Horwacik et al, 2015[16]; Shokeir et al, 2015[44]; Alzoubi et al, 2015[2]; Gabriel et al, 2015[13]; Kee et al, 2015[20]; Rizzo et al, 2014[38]; Pan et al, 2014[35]; Sayed et al, 2014[40]; Singh et al, 2014[46]; Maeda et al, 2014[31]; Zhang et al, 2014[54]; Lee et al, 2014[25]; Fimognari et al, 2014[12]; Jo et al, 2014[18]). …”