Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

Sharma, Dharmender; Sangha, Gurinder Kaur

doi:10.4172/2254-609x.100039

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…25 These findings agree with other studies in which Brassica phytochemicals showed antioxidant effects and decreased oxidative damage. 43,44 Experimental Chemicals All the reagents used were of the highest grade and were purchased from Sigma-Aldrich (St Louis, MO, USA), Carlo Erba (Milan, Italy), Bio-Rad Laboratories (Segrate, Italy) and GE Healthcare (Uppsala, Sweden).…”

Section: Effect Of Diet On Anti-inflammatory Factorsmentioning

confidence: 99%

Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

et al. 2017

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Brassica phytochemicals exert a broad spectrum of health-promoting activities. The aim of this study was to investigate the possible beneficial effects of a cauliflower leaf powder (CLP)-enriched diet to prevent inflammation and oxidative stress resulting from injection of lipopolysaccharide (LPS) into rabbits. Animals (24 rabbits) were randomly divided into two groups and fed with a standard diet (SD) or a standard diet supplemented with a 100 g kg diet of CLP. After 60 days, six rabbits of both groups received a LPS injection (100 μg per kg body weight). Serum samples collected after 90 min of LPS injection were assessed for their content of both inflammatory biomarkers such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and matrix-metalloproteinases (MMP-2 and MMP-9) and oxidative stress biomarkers such as thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). LPS increased the levels of TNF-α, IL-6, and TBARS as well as MMP-2 and MMP-9 activities, whereas it decreased the GSH levels and SOD and CAT activities. In conclusion, preventive supplementation with CLP can protect rabbits from the inflammation and oxidative stress induced by LPS.

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Section: Effect Of Diet On Anti-inflammatory Factorsmentioning

confidence: 99%

Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

et al. 2017

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“…Hasil penelitian Sharma & Sangha (2016) menyebutkan bahwa pemberian ekstrak brokoli yang mengandung glukosinolat menyebabkan penurunan stress oksidatif pada tikus yang diberi paparan toksisitas triazophos. Hasil penelitian tersebut menujukkan pemberian ekstrak brokoli sebanyak 20 µmol dan 30 µmol dapat menurunkan kadar MDA tikus putih betina secara signifikan dibandingkan dengan tikus yang diberi perlakuan triazophos.…”

Section: Kadar Malondialdehid (Mda)unclassified

Pengaruh ekstrak rumput laut (Eucheuma cottoni) terhadap kadar malondialdehid dan spermatozoa tikus (Rattus norvegicus L.) yang diinduksi natrium nitrit

Wirastuti¹,

Sukmaningsih

Sudirga

2022

JBIOUNUD

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Produk daging olahan adalah salah satu jenis pangan yang mudah mengalami kerusakan. Kerusakan pada produk daging olahan diakibatkan karena adanya pertumbuhan mikroorganisme. Menanggulangi hal tersebut, perusahaan pengolahan daging banyak menambahkan bahan tambahan pangan (BTP) yaitu natrium nitrit (NaNO2). Akumulasi nitrit yang berlebih dalam tubuh dapat menimbulkan efek yang merugikan pada sistem reproduksi. Penelitian oleh Pavlova et al. (2017) menemukan terjadi penurunan berat epididimis dan pengurangan jumlah spermatoa tikus yang diberi paparan NaNO2 tinggi. Rumput laut Eucheuma cottoni mengandung antioksidan yang dapat menetralkan sifat oksidatif yang ditimbulkan oleh NaNO2. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak rumput laut Eucheuma cottoni terhadap kadar Malondialdehid (MDA) dan spermatozoa pada tikus putih (Rattus norvegicus L.) jantan yang diinduksi NaNO2. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari kontrol negatif (K-), kontrol positif (K+), perlakuan dosis 1 (P1), perlakuan dosis 2 (P2) dan perlakuan 3 (P3). Kontrol negatif (K-) diberikan aquades sedangkan kontrol positif diberikan natrium nitrit dosis 22,5 mg/kg BB. Perlakuan dosis 1,2 dan 3 diberikan metode kombinasi natrium nitrit dan ekstrak rumput laut dosis 150 mg/kgBB/hari (P1), 300 mg/kgBB/hari (P2), dan 450 mg/kgBB/hari (P3). Pemberian perlakuan dilakukan selama 45 hari. Adapun variabel penelitian terdiri dari kadar MDA (Malondialdehid) pada serum dan kualitas spermatozoa meliputi integritas membran, viabilitas, motilitas dan morfologi spermatozoa dari tikus putih jantan. Analisis data dilakukan melalui uji statistik One Way Anova dan dilanjutkan dengan uji Duncan. . Hasil penelitian menunjukkan ekstrak rumput laut dosis 150 mg/kgBB mampu menurunkan kadar MDA (Malondialdehid), meningkatkan motilitas, viabilitas, integritas membran dan morfologi spermatozoa secara signifikan.

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“…Loss of cholinergic markers enzymes such as AChE is correlating with the degree of cognitive and loss of this enzymes is considered the most severe and the earliest of the biochemical changes to occur. Chronic Aluminium exposure has choline toxic effects and significant reduction of AChE activity is seen with Aluminium [45][46][47]. Aluminum can result in the production of free radicals which lead to oxidative damage, and this may be responsible for the decreased AChE enzyme activity.…”

Section: Treatedmentioning

confidence: 99%

Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

Al-Balawi

Ahmed

Albukhari

et al. 2019

JPRI

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Backgound: The generation of oxidative stress can be referred to Aluminium toxic effect in animals and humans. This study aimed to evaluate the role of broccoli (Br) and beetroot (Be) extarcts as antioxidant that prevents oxidative stress that associated with aluminum toxicity. Materials and Methods: Fifty Wister female rats were grouped into five groups (each 10 rats): Group 1: control group, administered drinking water only. Group 2: (Neurogenerative) which were induced by oral administration of aluminum chloride (20 mg/kg b.w) daily for one month. Group 3: Rats given aluminum chloride were treated with Rivastigmine (Ri) (1 mg/kg b.w) as a reference drug daily for five weeks. Group 4: Rats given aluminum chloride were treated with beet root extract (50 mg/kg b.w) daily for six weeks. Group 5. Rats given aluminum chloride were treated with broccoli extract (50 mg/kg b.w) daily for five weeks. Results: (AlCl3) group showed a significant increase in Ach level (P<0.05) and a non-significant change in DOP and NE levels compared to control. (AlCl3+Be) was non-significant (P˂0.05) change in Ach, DOP and NE levels compared to (AlCl3) group and showed a significant (P<0.05) increase in Ach level compared to control. (AlCl3+Br) showed a significant (P<0.05) increase in NE level and non-significant (P˂0.05) change in Ach and DOP levels compared to (AlCl3) group. (AlCl3+Ri) showed a significant (P<0.05) increase in Ach, DOP and NE levels compared to (AlCl3) group. Also, showed a significant (P<0.05) increase in Ach and NE compared to control. Conclusion: Neuroprotective role of broccoli in the present study which may result from its antioxidant properties due to its bioactive content such as glucosinolate, isothiocyanate, Sulforaphane, and flavonoids. Therefore, Broccoli can have a favorable effect on neurotoxicity due to their antioxidant and anti-inflammatory properties.

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Effects of Glucosinolates Rich Broccoli extract against Triazophos induced Toxicity in Wistar Rats

Cited by 4 publications

References 22 publications

Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

Antioxidant and anti-inflammatory effects of cauliflower leaf powder-enriched diet against LPS induced toxicity in rabbits

Pengaruh ekstrak rumput laut (Eucheuma cottoni) terhadap kadar malondialdehid dan spermatozoa tikus (Rattus norvegicus L.) yang diinduksi natrium nitrit

Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

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