“…While initially welcomed, this feature has been found to be disadvantageous in elderly patients in whom the drug can accumulate and thereby produce hypoglycaemia. Other longer-acting sulfonylureas have been marketed, including highly potent agents such as glibenclamide (glyburide) 81 and glipizide. 82 Proguanil On the outbreak of the Second World War, a high-priority rating was given to a scheme established by the British Medical Research Council to develop new antimalarial drugs.…”