Sulfonic Acid Derivative-Modified SBA-15, PHTS and MCM-41 Mesoporous Silicas as Carriers for a New Antiplatelet Drug: Ticagrelor Adsorption and Release Studies

Moritz, Michał; Geszke-Moritz, Małgorzata

doi:10.3390/ma13132913

Cited by 9 publications

(6 citation statements)

References 65 publications

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“…They have claimed that the absence of the melting peak of doxycycline hyclate in the DSC curve resulted from the formation of an inclusion complex between drug molecules and β-cyclodextrin. Moreover, the disappearance of DSC peaks characteristic for melting points of other drugs such as aprepitant [ 33 ], ketoprofen [ 34 ], ticagrelor [ 35 ] have been reported for various mesoporous silicas and suggested both the successful encapsulation of drug molecules and their amorphous or semi-crystalline nature inside the pores.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

Szewczyk

Skwira

Konopacka

et al. 2021

IJMS

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For decades, local bone drug delivery systems have been investigated in terms of their application in regenerative medicine. Among them, inorganic polymers based on amorphous silica have been widely explored. In this work, we combined two types of amorphous silica: bioglass and doxycycline-loaded mesoporous silica MCM-41 into the form of spherical granules (pellets) as a bifunctional bone drug delivery system. Both types of silica were obtained in a sol-gel method. The drug adsorption onto the MCM-41 was performed via adsorption from concentrated doxycycline hydrochloride solution. Pellets were obtained on a laboratory scale using the wet granulation-extrusion-spheronization method and investigated in terms of physical properties, drug release, antimicrobial activity against Staphylococcus aureus, mineralization properties in simulated body fluid, and cytotoxicity towards human osteoblasts. The obtained pellets were characterized by satisfactory mechanical properties which eliminated the risk of pellets cracking during further investigations. The biphasic drug release from pellets was observed: burst stage (44% of adsorbed drug released within the first day) followed by prolonged release with zero-order kinetics (estimated time of complete drug release was 19 days) with maintained antimicrobial activity. The progressive biomimetic apatite formation on the surface of the pellets was observed. No cytotoxic effect of pellets towards human osteoblasts was noticed.

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Section: Resultsmentioning

confidence: 99%

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

Szewczyk

Skwira

Konopacka

et al. 2021

IJMS

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“…We hope that this simple procedure can be easily applied for other sorbents and environmental samples so that methodological biases introduced by SPE in aquatic research can be more conveniently assessed in future. It should be noted that classical adsorption models such as Thomas model, 54 Langmuir isotherm, 55 or Dubinin-Astakhov isotherm 56 are difficult to be applied due to the heterogeneous and complex nature of aquatic DOM. Although we do not know precisely how many organic compounds are contained in water, mass spectrometry yields at least 10,000 different molecular masses and an unknown dimension of structural isomers within each sample.…”

Section: ■ Discussionmentioning

confidence: 99%

Solid-Phase Extraction of Aquatic Organic Matter: Loading-Dependent Chemical Fractionation and Self-Assembly

Kong

Jendrossek

Ludwichowski

et al. 2021

Environ. Sci. Technol.

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Dissolved organic matter (DOM) is an important component in marine and freshwater environments and plays a fundamental role in global biogeochemical cycles. In the past, optical and molecular-level analytical techniques evolved and improved our mechanistic understanding about DOM fluxes. For most molecular chemical techniques, sample desalting and enrichment is a prerequisite. Solid-phase extraction has been widely applied for concentrating and desalting DOM. The major aim of this study was to constrain the influence of sorbent loading on the composition of DOM extracts. Here, we show that increased loading resulted in reduced extraction efficiencies of dissolved organic carbon (DOC), fluorescence and absorbance, and polar organic substances. Loading-dependent optical and chemical fractionation induced by the altered adsorption characteristics of the sorbent surface (styrene divinylbenzene polymer) and increased multilayer adsorption (DOM self-assembly) can fundamentally affect biogeochemical interpretations, such as the source of organic matter. Online fluorescence monitoring of the permeate flow allowed to empirically model the extraction process and to assess the degree of variability introduced by changing the sorbent loading in the extraction procedure. Our study emphasizes that it is crucial for sample comparison to keep the relative DOC loading (DOC load [wt %]) on the sorbent always similar to avoid chemical fractionation.

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“…Moritz [23] synthesized three typical mesoporous (SBA-15, PHTS and MCM-41) functionalized with a sulfonic acid derivative and were applied successfully as the carriers for the poorly water-soluble drug.…”

Section: Introductionmentioning

confidence: 99%

RAFT polymerization of MMA in channels of different mesoporous materials

Xue

Yan

et al. 2023

Chem. Pap.

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Reversible addition fragmentation transfer (RAFT) polymerization is of key signi cance for its suitability for most monomer and well-studied reaction mechanism. Herein, a serial of mesoporous silica (MS) materials, including rod-liked and spherical SBA-15, spherical MCM-41, and MCM-48, were successfully synthesized and modi ed by silane coupling agent γ-aminopropyltriethoxysilane (KH550). The modi ed MS was utilized as a microreactor for reversible addition-fragmentation chain transfer (RAFT) polymerization of methyl methacrylate (MMA) using a xanthate as a chain transfer agent and AIBN as an initiator. Note that modi ed MS had lower speci c surface area and pore volume while maintained the original morphological structure. Owing to the con nement effects, poly(methyl methacrylate) (PMMA) prepared from internal mesoporous channels featured with higher molecule weight and initial thermal decomposition temperature than these from conventional RAFT polymerization. More importantly, the PMMA obtained from the spherical SBA-15 and modi ed MCM-48 exhibited the highest molecule weight.This work provided a novel approach to design of polymer microstructure for a wider application, such as in drug release. AR), ammonia water (NH 3 •H 2 O, 25-28%), tetraethyl orthosilicate (TEOS, AR), hydro uoric acid (HF, ≥ 40%) hydrochloric acid (HCl,(36)(37)(38), and tetrahydrofuran (THF, AR) were all purchased from Xilong Science and Technology Co., Ltd. MMA was treated with 10% aqueous NaOH solution for three times to remove the inhibitor, then washed with distilled water to be neutral, dried with anhydrous CaCl 2 , and distilled under reduced pressure. Anhydrous ethanol (AR) was purchased from Guangdong Guanghua Technology Co., Ltd. Azodiisobutyronitrile (AIBN, AR), purchased from Tianjin Guangfu Fine Chemical Research Institute, was used after recrystallization from absolute ethanol. Potassium ethyl xanthate (AR) and ethyl 2-bromopropionate (AR) were purchased from Aladdin Industrial Corporation (Shanghai, China) and used directly. γ-aminopropyltriethoxysilane (KH550, CP) was purchased from Nanjing Xiangfei Chemical Research Institute. Ethyl xanthate ethyl propionate was synthesized according to the reported work [24]. All other chemicals were used as received without further puri cation.

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Sulfonic Acid Derivative-Modified SBA-15, PHTS and MCM-41 Mesoporous Silicas as Carriers for a New Antiplatelet Drug: Ticagrelor Adsorption and Release Studies

Cited by 9 publications

References 65 publications

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

Solid-Phase Extraction of Aquatic Organic Matter: Loading-Dependent Chemical Fractionation and Self-Assembly

RAFT polymerization of MMA in channels of different mesoporous materials

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