Sulfonamide-functionalized covalent organic framework (COF-SO3H): an efficient heterogeneous acidic catalyst for the one-pot preparation of polyhydroquinoline and 1,4-dihydropyridine derivatives

Novel Polyhydroquinoline-Hydrazide-Linked Schiff’s Base Derivatives: Multistep Synthesis, Antimicrobial, and Calcium-Channel-Blocking Activities

“…Heterocycles containing polyhydroquinoline (PHQ) are asymmetric Hantzsch derivative of 1,4-dihydropyridines (1,4-DHPs) that are obtained by a four-component process [ 1 ]. They are a noticeable class of privileged compounds that are highly recognized in the field of medicines and organic chemistry [ 2 , 3 , 4 , 5 ] due to their pharmacological and biological activities. Some of the derivatives are well-known calcium- (Ca 2+ )-channel blockers [ 6 ] and have been reported to have anti-tubercular [ 7 ] bronchodilator properties [ 8 ], neuroprotection [ 9 ] anti-hyperglycemic [ 10 ], anti-diabetic [ 11 , 12 ], anti-inflammatory [ 13 ], platelet anti-aggregation [ 14 ], neuroprotective [ 15 ], anticancer [ 16 ], antibacterial [ 17 ], and antioxidant activities [ 18 ].…”

Evolving Trends for C−C Bond Formation Using Functionalized Covalent Organic Frameworks as Heterogeneous Catalysts

“…Various 1,4‐dihydropyridines were reportedly prepared by Farsi and co‐workers [119] through solvent‐free, one‐pot, multicomponent Hantzsch reaction of aldehydes and ammonium acetate with 2 equivalents of ethyl acetoacetate in the presence of sulfonamide tailored COF (COF‐SO 3 H, Figure 42) as the catalyst (Scheme 25). They have also synthesized polyhydroquinoline derivatives by one‐pot, four‐component reaction of aldehydes, ammonium acetate, ethyl acetoacetate and dimedone under the same reaction conditions (Scheme 25).…”

Synthesis and application of novel urea–benzoic acid functionalized magnetic nanoparticles for the synthesis of 2,3-disubstituted thiazolidin-4-ones and hexahydroquinolines

“…[34][35][36] Hexahydroquinolines as one of the main important family of 1,4-dihydropyridines, have been studied profoundly. [37][38][39] Several critical biological applications Fig. 1 FT-IR spectra of Fe 3 O 4 @SiO 2 @(CH 2 ) 3 -urea-benzoic acid and its related intermediates.…”

“…34–36 Hexahydroquinolines as one of the main important family of 1,4-dihydropyridines, have been studied profoundly. 37–39 Several critical biological applications and therapeutic activities such as antiplasmodial, 40 antimalarial, 41 antidiabetic, 42 anticancer, 43 bronchodilator, 44 antiatherosclerotic, 45 vasodilator, 46 antibacterial properties 47 and calcium channel blockers in cardiovascular disease treatment 48 have been devoted for these versatile compounds. The structure of some biologically active hexahydroquinolines derivatives is sketched in the Scheme 1.…”