Sulfation modification and anticoagulant activity of the polysaccharides obtained from persimmon (Diospyros kaki L.) fruits

Sulfated polysaccharides from Cyclocarya paliurus reduce H 2 O 2 -induced oxidative stress in RAW264.7 cells

“…However, it could be concluded that the addition of sulfate group could result in the increasing of Mw. The difference of physicochemical properties between the two sulfated derivatives was attributed to the ratios of CSA-Pyr [31].…”

“…These results suggest that the sulfate group is not the only factor around antioxidant activities of polysaccharides, the sulfated modification would improve protective effects only at a proper sulfate content [16]. It was known that the degradation of polysaccharides in sulfated modification due to high temperature and acid process could reduce the biological activity obviously [31]. These studies thus offered a new strategy that to obtain highly active polysaccharides need necessary optimum condition.…”

Molecular Modification of Polysaccharides and Resulting Bioactivities

“…Research results have shown that natural polysaccharide bioactivities are related to their own properties such as types of glycosidic bond, solubility (Lu and others ), relative molecular mass (Li and Shah ), main‐chain configuration (Hattori and others ), and spatial configuration (Wang and others ). Among these, types of glycosidic bond, ways of connections, and monosaccharide compositions are the most important, as they are the key to determine whether the polysaccharides have bioactivities, while others can only affect the levels of bioactivities.…”

“…Sulfated persimmon polysaccharides have antiviral activity compared with the nonsulfated ones (Lu and others ), which is possibly due to the poly‐anionic characteristics of sulfate groups. Sulfate poly‐anion has a strong negative charge, and it can be combined with molecules which possess a positive charge on the receptor cell surface, thus interfering with adsorption of virus to the receptor cells and inhibiting virus reverse transcriptase (Thuy and others ).…”

Antioxidant and Antibacterial Activity of Water Soluble Polysaccharide from Defatted Botryococcus braunii

“…-72 -Esterification, oxidation, hydroxypropylation에 의한 다당의 화학적 유도체화 중, 특히 중합체 구조에서 수산기가 황산기로 대체되는 황산화 과정은 다당의 생리적 기능에 영향을 미친다 [6,13]. 다당의 황산화 를 위한 반응 시약은 일반적으로 pyridine의 ClSO 3 H 또는 아민 또는 N,N'-Dimethylformamide (DMF)와 sulfur trioxide 복합체가 이용되고 있다 [14].…”