Sulfated polysaccharides from Undaria pinnatifida improved high fat diet-induced metabolic syndrome, gut microbiota dysbiosis and inflammation in BALB/c mice

Jiang, Pingrui; Zheng, Weiyun; Sun, Xiao; Jiang, Guoping; Wu, Shuang; Xu, Yan; Song, Shuang; Ai, Chunqing

doi:10.1016/j.ijbiomac.2020.11.116

Cited by 56 publications

(45 citation statements)

References 45 publications

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Section: Resultsmentioning

confidence: 99%

“…Sulfated polysaccharides isolated from seaweeds have been reported to possess various bioactivities [ 12 , 13 , 14 , 15 , 16 , 17 ]. In particular, seaweed-derived sulfated polysaccharides possess potent immunostimulatory and anti-inflammatory effects [ 12 , 17 ]. Our previous studies have investigated the anti-inflammatory effects of sulfated polysaccharides isolated from different seaweeds including Chnoospora minima , Sargassum horneri , Saccharina japonica , Hizikia fusiforme , and Padina commersonii [ 3 , 4 , 18 , 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

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In Vitro and In Vivo Anti-Inflammatory Effects of Sulfated Polysaccharides Isolated from the Edible Brown Seaweed, Sargassum fulvellum

et al. 2021

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In the present study, the in vitro and in vivo anti-inflammatory effects of the sulfated polysaccharides isolated from Sargassum fulvellum (SFPS) were evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and zebrafish. The results indicated that SFPS improved the viability of LPS-stimulated RAW 264.7 macrophages from 80.02 to 86.80, 90.09, and 94.62% at the concentration of 25, 50, and 100 µg/mL, respectively. Also, SFPS remarkably and concentration-dependently decreased the production levels of inflammatory molecules including nitric oxide (NO), tumor necrosis factor-alpha, prostaglandin E2, interleukin-1 beta, and interleukin-6 in LPS-treated RAW 264.7 macrophages. In addition, SFPS significantly inhibited the expression levels of cyclooxygenase-2 and inducible nitric oxide synthase in LPS-treated RAW 264.7 macrophages. Furthermore, the in vivo test results indicated that SFPS improved the survival rate of LPS-treated zebrafish from 53.33 to 56.67, 60.00, and 70.00% at the concentration of 25, 50, and 100 µg/mL, respectively. In addition, SFPS effectively reduced cell death, reactive oxygen species, and NO levels in LPS-stimulated zebrafish. Taken together, these results suggested that SFPS possesses strong in vitro and in vivo anti-inflammatory activities, and could be used as an ingredient to develop anti-inflammatory agents in the functional food and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

In Vitro and In Vivo Anti-Inflammatory Effects of Sulfated Polysaccharides Isolated from the Edible Brown Seaweed, Sargassum fulvellum

et al. 2021

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“…Dietary change is the main strategy for the treatment of metabolic syndrome, and the development of functional food components is an important method. In recent years, marine sulfate polysaccharides (MSPs) have shown to be effective in the prevention and treatment of metabolic syndrome [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…change is the main strategy for the treatment of metabolic syndrome, ment of functional food components is an important method. In recent fate polysaccharides (MSPs) have shown to be effective in the prevent of metabolic syndrome [5,6]. Sulfated polysaccharides (SPs) are sulfated derivatives of polysacc multifunctional active compounds formed by substituting some hydrox osaccharide molecules in the chain of polysaccharides by sulfate radi special environment of the sea, polysaccharides from marine organism more sulfate groups than polysaccharides from terrestrial microorgani plants [8,9].…”

Section: Introductionmentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

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“…Medicinal foods have also been shown to improve the quality of life in women during the menopausal stage [ 19 , 20 ]. Indeed, traditional medicinal foods such as seaweed polysaccharides were shown to effectively reduce gut dysbiosis [ 21 , 22 ]. Therefore, there is a great medical need and commercial interest to determine the therapeutic value of medicinal foods used in Traditional Chinese Medicine (TCM).…”

Section: Introductionmentioning

confidence: 99%

Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach

et al. 2021

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Astragalus root (Huang Qi) and Shiitake mushrooms (Lentinus edodes) are both considered medicinal foods and are frequently used in traditional Chinese medicine due to their anticancer and immunomodulating properties. Here, the scientific literatures describing evidence for the anticancer and immunogenic properties of Shiitake and Astragalus were reviewed. Based on our experimental data, the potential to develop medicinal food with combined bioactivities was assessed using Shiitake mushrooms grown over Astragalus beds in a proprietary manufacturing process, as a novel cancer prevention approach. Notably, our data suggest that this new manufacturing process can result in transfer and increased bioavailability of Astragalus polysaccharides with therapeutic potential into edible Shiitake. Further research efforts are required to validate the therapeutic potential of this new Hengshan Astragalus Shiitake medicinal food.

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Sulfated polysaccharides from Undaria pinnatifida improved high fat diet-induced metabolic syndrome, gut microbiota dysbiosis and inflammation in BALB/c mice

Cited by 56 publications

References 45 publications

In Vitro and In Vivo Anti-Inflammatory Effects of Sulfated Polysaccharides Isolated from the Edible Brown Seaweed, Sargassum fulvellum

In Vitro and In Vivo Anti-Inflammatory Effects of Sulfated Polysaccharides Isolated from the Edible Brown Seaweed, Sargassum fulvellum

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach

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