In Vitro and In Vivo Anti-Inflammatory Effects of Sulfated Polysaccharides Isolated from the Edible Brown Seaweed, Sargassum fulvellum

Wang, Lei; Yang, Hye-Won; Ahn, Ginnae; Fu, Xiaoting; Xu, Jiachao; Gao, Xin; Jeon, You‐Jin

doi:10.3390/md19050277

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…Hu et al (2014) associated the analgesic effect of fucoidan after intrathecal injection with inhibition of spinal astrocytic and microglial activation, proinflammatory mediator production, and mitogen-activated protein kinases (MAPK) activation. This hypothesis is supported by recent studies, which indicate suppression of the production of TNF-α, prostaglandins, and interleukins [13,14], as well as potent inhibition of kinases, including ENK, JNK, Akt [16], and MAPK p38 [12], by fucoidan. The rationality of topical application of formulations with fucoidan was confirmed in our recent study [47], in which fucoidan was found in the skin, plasma, and striated muscles.…”

Section: Anti-inflammatory Activitysupporting

confidence: 53%

“…Due to the complexity of inflammation processes, there is an urgent need for the development of new and safe anti-inflammatory agents with multiple mechanisms of action. Anti-inflammatory mechanisms described for fucoidan include scavenging of free radicals [11,12], suppression of the production of nitric oxide, tumor necrosis factor-alpha (TNF-α), prostaglandin E2, interleukin-1 beta, and interleukin-6 [13,14], selective inhibition of cyclooxygenase-2 [12], and downregulation of the expression of mitogen-activated protein kinase p38, Akt, extracellular signal-regulated kinase (ENK), and c-Jun N-terminal kinase (JNK) [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

et al. 2021

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Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoidan-based cream formulation and to investigate its anti-inflammatory potential after topical application in vivo. Fucoidan from Fucus vesiculosus L. was used. The cream base consisting of olive oil and Kolliphor RH40 was optimized followed by in vitro agar diffusion and drug release studies. The fucoidan-based cream with 13% Kolliphor P 407, 1% Transcutol P, and 5% PEG400 showed good spreadability, washability, and colloidal stability, and it did not irritate the skin. The kinetics of fucoidan release from the optimized cream exhibited the best fit to the Korsmeyer–Peppas and Higuchi models with R2 > 0.99. Fucoidan release was controlled by drug diffusion and anomalous transport provided by the optimized cream base. The formulation was stable and provided high fucoidan release after storage for 1 year. Topical application of the fucoidan-based cream dose-dependently inhibited carrageenan-induced edema and ameliorated mechanical allodynia in rats. The efficacy of the fucoidan-based cream at a high dose was comparable with the efficacy of diclofenac gel. The fucoidan-based cream could be considered a promising anti-inflammatory formulation.

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Section: Anti-inflammatory Activitysupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

et al. 2021

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“…On the other hand, none of the fractions were able to stimulate the production of IL-10. These results agree with those found in the literature [ 50 , 51 ], where brown seaweeds also revealed anti-inflammatory potential. Han and co-workers [ 52 ] evaluated the anti-inflammatory effect of sargacromenol isolated from Sargassum horneri in RAW 264.7 macrophages stimulated by LPS.…”

Section: Discussionsupporting

confidence: 93%

Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations

et al. 2022

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The growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed Saccorhiza polyschides. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymatic (collagenase, elastase, hyaluronidase and tyrosinase), antimicrobial (Staphylococcus epidermidis, Cutibacterium acnes and Malassezia furfur), anti-inflammatory (nitric oxide, tumor necrosis factor-α, interleukin-6 and interleukin-10) and photoprotective (reactive oxygen species) properties of all fractions were evaluated. The ethyl acetate fraction (F3) displayed the highest antioxidant and photoprotective capacity, reducing ROS levels in UVA/B-exposed 3T3 fibroblasts, and the highest anti-enzymatic capacity against tyrosinase (IC50 value: 89.1 µg/mL). The solid water-insoluble fraction (F5) revealed the greatest antimicrobial activity against C. acnes growth (IC50 value: 12.4 µg/mL). Furthermore, all fractions demonstrated anti-inflammatory potential, reducing TNF-α and IL-6 levels in RAW 264.7 macrophages induced with lipopolysaccharides. Chemical analysis of the S. polyschides fractions by NMR revealed the presence of different classes of compounds, including lipids, polyphenols and sugars. The results highlight the potential of S. polyschides to be incorporated into new nature-based skincare products.

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“…A sulfated polysaccharide isolated from Sargassum fulvellum demonstrated a significant and concentration-dependent decrease in the production levels of NO, TNF-α, PGE2, IL-6, and IL-1β in LPS-treated RAW 264.7 macrophages [132].…”

Section: Cellular Signal/corticoresistancementioning

confidence: 94%

Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

et al. 2021

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One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent biologically active properties for biomedical applications, as well as their sustainability and safety for drug development. Based on the pathobiological features associated with glucocorticoid resistance in severe asthma, many studies have already described many glucocorticoid resistance mechanisms as potential therapeutic targets. On the other hand, in the last decade, many studies described the potentially anti-inflammatory effects of marine-derived biologically active compounds. Analyzing the underlying anti-inflammatory mechanisms of action for these marine-derived biologically active compounds, we observed some of the targeted pathogenic molecular mechanisms similar to those described in glucocorticoid (GC) resistant asthma. This article gathers the marine-derived compounds targeting pathogenic molecular mechanism involved in GC resistant asthma and provides a basis for the development of effective marine-derived drugs.

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In Vitro and In Vivo Anti-Inflammatory Effects of Sulfated Polysaccharides Isolated from the Edible Brown Seaweed, Sargassum fulvellum

Cited by 19 publications

References 27 publications

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations

Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

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