Sulfated polysaccharides from pacific abalone attenuated DSS-induced acute and chronic ulcerative colitis in mice<i>via</i>regulating intestinal micro-ecology and the NF-κB pathway

Jia, Jinhui; Zhang, Panpan; Zhang, Chenxi; Jiang, Guoping; Zheng, Weiyun; Song, Shuang; Ai, Chunqing

doi:10.1039/d1fo02431k

Cited by 20 publications

(13 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that the Lachnospiraceae taxa could contribute to the general symptoms of IBS [ 55 , 56 ]. Jia et al [ 57 ] reported that the abundance of Bacteroidaceae increased significantly and Lactobacillaceae decreased significantly in the DSS-treated mice, and our results were consistent with this finding. Recent studies have also found that intestinal dysbacteriosis was the leading cause of infantile diarrhea and Lactobacillaceae could alleviate the severity of diarrhea [ 58 , 59 ].…”

Section: Discussionsupporting

confidence: 92%

Effects of Lacidophilin Tablets, Yogurt, and Bifid Triple Viable Capsules on the Gut Microbiota of Mice with Antibiotic-Associated Diarrhea

Yang¹,

Zhan²,

Wan³

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Antibiotic-associated diarrhea (AAD) is a common morbidity caused by antibiotic use and is characterized by the dysbiosis of the gut microbiota. Several clinical trials have shown that probiotics can prevent AAD. This study aimed at investigating the effects of Lacidophilin tablets (LB), yogurt (YG), and bifid triple viable capsules (BT) on the gut microbiota of mice with AAD. Mice with diarrhea were randomly allocated to treatment groups or the control group and were treated with either LB, YG, BT, or vehicle control. The body weight, diarrhea scores, cecum index, and cecal length were determined. Fecal samples of all mice were analyzed using 16S rRNA high-throughput sequencing. The results showed that LB, YG, and BT significantly decreased the diarrhea scores and inhibited increases in the cecum index and cecal length induced by AAD. In addition, they significantly changed the composition and richness of the gut microbiota. Specifically, they increased the abundance of the phylum Firmicutes and decreased the abundance of the phyla Bacteroidetes and the family Bacteroidaceae. Treatment with LB and YG also decreased the abundance of the phylum Proteobacteria and only LB could mediate the reduced levels of Lactobacillaceae in AAD mice. At the genus level, YG and BT treatment decreased the abundance of Bacteroides or Parasutterella. To our surprise, only LB treatment dramatically increased the abundance of Lactobacillus and decreased that of potential pathogens, such as Bacteroides, Parabacteroides, and Parasutterella, to almost normal values. Our findings indicate that LB, YG, and BT ameliorated diarrhea by regulating the composition and structure of the gut microbiota and that LB plays an important role in regulating the gut microbiota.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of Lacidophilin Tablets, Yogurt, and Bifid Triple Viable Capsules on the Gut Microbiota of Mice with Antibiotic-Associated Diarrhea

Yang¹,

Zhan²,

Wan³

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

“…α- d -Glucan and β- d -glucan from marine fungus Phoma herbarum YS4108 and yeast, respectively, have been proven to ameliorate mice colitis by inhibiting the expression of inflammatory mediators and enhancing the expression of TJ proteins associated with intestinal permeability. Additionally, acidic heteropolysaccharides, such as the sulfated polysaccharide from Pacific abalone, which was composed of Man, Glc, Gal, and GlcA in the molar ratio of 0.9:0.6:16.7:5.2, could attenuate DSS-induced acute and chronic UC in mice via regulating intestinal microecology and the NF-κB pathway . Acidic polysaccharides have a net negative charge and can interact with positively charged amino acids located at the C and N termini of mucin .…”

Section: Protective Effect Of Polysaccharides On Intestinal Barrier F...mentioning

confidence: 99%

“…Additionally, acidic heteropolysaccharides, such as the sulfated polysaccharide from Pacific abalone, which was composed of Man, Glc, Gal, and GlcA in the molar ratio of 0.9:0.6:16.7:5.2, could attenuate DSS-induced acute and chronic UC in mice via regulating intestinal microecology and the NF-κB pathway. 166 Acidic polysaccharides have a net negative charge and can interact with positively charged amino acids located at the C and N termini of mucin. 162 This feature affects mucosal interactions and mucus barrier properties to improve the mucus barrier in colitis mice.…”

Section: ■ Pathogenesis Of Intestinal Barrier Injurymentioning

confidence: 99%

Protective Effects of Natural Polysaccharides on Intestinal Barrier Injury: A Review

Huo

Sun

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Owing to their minimal side effects and effective protection from oxidative stress, inflammation, and malignant growth, natural polysaccharides (NPs) are a potential adjuvant therapy for several diseases caused by intestinal barrier injury (IBI). More studies are accumulating on the protective effects of NPs with respect to IBI, but the underlying mechanisms remain unclear. Thus, this review aims to represent current studies that investigate the protective effects of NPs on IBI by directly maintaining intestinal epithelial barrier integrity (inhibiting oxidative stress, regulating inflammatory cytokine expression, and increasing tight junction protein expression) and indirectly regulating intestinal immunity and microbiota. Furthermore, the mechanisms underlying IBI development are briefly introduced, and the structure–activity relationships of polysaccharides with intestinal barrier protection effects are discussed. Potential developments and challenges associated with NPs exhibiting protective effects against IBI have also been highlighted to guide the application of NPs in the treatment of intestinal diseases caused by IBI.

show abstract

“…Polysaccharides from S. baicalensis Georgi ameliorated colitis via suppression of the NF-κB signaling pathway [128] while increasing the levels of Firmicutes, Bifidobacterium, Lactobacillus, and Roseburia and reducing the levels of Bacteroides, Proteobacteria, and Staphylococcus [65]. Similarly, Pacific abalone polysaccharides could inhibit the activation of the NF-κB signaling pathway, increase Muribaculaceae and Lachnospiraceae abundance, and decrease Bacteroidaceae, Prevotellaceae, and Rickenellaceae abundance [129].…”

Section: Effect On Intestinal Immunity and Inflammatory Responsesmentioning

confidence: 99%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

View full text Add to dashboard Cite

The incidence of inflammatory bowel disease (IBD) has increased in recent years. Considering the potential side effects of conventional drugs, safe and efficient treatment methods for IBD are required urgently. Natural polysaccharides (NPs) have attracted considerable attention as potential therapeutic agents for IBD owing to their high efficiency, low toxicity, and wide range of biological activities. Intestinal microbiota and their fermentative products, mainly short-chain fatty acids (SCFAs), are thought to mediate the effect of NPs in IBDs. This review explores the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbes. Intestinal microbiota exert alleviation effects via various mechanisms, such as increasing the intestinal immunity, anti-inflammatory activities, and intestinal barrier protection via microbiota-dependent and microbiota-independent strategies. The aim of this paper was to document evidence of NP–intestinal microbiota-associated IBD prevention, which would be helpful for guidance in the treatment and management of IBD.

show abstract

Sulfated polysaccharides from pacific abalone attenuated DSS-induced acute and chronic ulcerative colitis in miceviaregulating intestinal micro-ecology and the NF-κB pathway

Abstract: Due to potential side effects of current drugs in colitis treatment, polysaccharides with anti-inflammatory activity can be considered as an alternative molecule for colitis treatment. Sulfated polysaccharide from pacific abalone...

Cited by 20 publications

References 40 publications

Effects of Lacidophilin Tablets, Yogurt, and Bifid Triple Viable Capsules on the Gut Microbiota of Mice with Antibiotic-Associated Diarrhea

Effects of Lacidophilin Tablets, Yogurt, and Bifid Triple Viable Capsules on the Gut Microbiota of Mice with Antibiotic-Associated Diarrhea

Protective Effects of Natural Polysaccharides on Intestinal Barrier Injury: A Review

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Contact Info

Product

Resources

About