Sulbactam plus Ampicillin: Interim Review of Efficacy and Safety for Therapeutic and Prophylactic Use

Lees, L.; Milson, J; Knirsch, Anthony K.; Greenhalgh, Katie

doi:10.1093/clinids/8.supplement_5.s644

Cited by 40 publications

(22 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, co-administration of AMP and SBT (ampicillin/sulbactam (AMS)) (Unasyn ® ; Pfizer Inc.), commonly in a 2:1 ratio, has been used successfully in clinical practice to overcome ␤-lactam resistance in various pathogenic strains [1,3]. The clinical usefulness of the parenteral formulation of AMS is well established in a wide variety of infections, with a cure or improved clinical outcome and bacteriological success in up to 92% of patients in early controlled clinical trials [14].…”

Section: The Role Of β-Lactamase Inhibitorsmentioning

confidence: 99%

Rational antibiotic therapy and the position of ampicillin/sulbactam

Lode

2008

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

Section: The Role Of β-Lactamase Inhibitorsmentioning

confidence: 99%

Rational antibiotic therapy and the position of ampicillin/sulbactam

Lode

2008

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

“…The combination has also proven to be effective in over 80 % of the clinical infections due to these organisms (7)(8)(9).…”

Section: Of Sulbactam Broadens the In Vitro Antibacterialmentioning

confidence: 99%

Comparison of fixed concentration and fixed ratio options for dilution susceptibility testing of gram-negative bacilli to ampicillin and ampicillin/sulbactam

Pfaller

Barry²,

Fuchs

et al. 1993

Eur. J. Clin. Microbiol. Infect. Dis.

View full text Add to dashboard Cite

Ampicillin combined with sulbactam was tested at both fixed ratio (2:1 and 1:1) and fixed sulbactam concentrations (4 micrograms/ml, 8 micrograms/ml and 16 micrograms/ml) against 2440 consecutively isolated gram-negative bacilli. Sulbactam significantly enhanced the spectrum of ampicillin activity. Overall, at 8 micrograms/ml ampicillin inhibited 50% of the Enterobacteriaceae isolates, whereas 69% to 84% of the isolates were inhibited by the various sulbactam combinations. The widest spectrum of activity for ampicillin/sulbactam was achieved by testing at a fixed sulbactam concentration of 16 micrograms/ml, followed by the 1:1 ratio and the fixed 8 micrograms/ml (84%, 76% and 74% inhibited, respectively). The amount of sulbactam at the susceptible breakpoint concentrations of ampicillin markedly affected the percentage of susceptible strains. Combinations that include 8 micrograms/ml of sulbactam are suggested for consideration.

show abstract

“…Sulbactam, Sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide, like other β lactamase inhibitors, can be combined with one of many β lactam antibiotics to prevent their destruction by β lactamase for the treatment of infection due to variety of organism staphylococuus aureus, Haemophilius influenza [3] . Both ceftazidime [4] and sulbactam [4] are listed individually in USP.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of High Performance Liquid Chromatographic Method for the Simultaneous Determination of Ceftazidime and Sulbactam in Spiked Plasma and Combined Dosage form-Zydotam

Siddiqui¹,

Tariq²,

Chaudhary³

et al. 2009

American J. of Applied Sciences

View full text Add to dashboard Cite

Problem statement:To develop a sensitive method to determine simultaneously ceftizidime and sulbactam in spiked plasma and combined formulation. Approach: In this study an isocratic High performance liquid chromatographic method with UV detection at 230 nm was described for simultaneous determination of Ceftazidime and sulbactam sodium in plasma and combined dosage form. Chromatographic separation of two drugs was achieved on a Hypersil ODS C-18 column using a mobile phase consisting of a binary mixture of acetonitrile and tetrabutyl ammonium hydroxide adjusted to pH 5.0 with orthophosphoric acid in ratio 25:75. Results: The developed performance liquid chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for both drugs. Linearity, accuracy and precision were found to be acceptable over the concentration range of 125-625 ppm for Ceftazidime and 62.5-312.5 ppm for sulbactam sodium. Conclusion: The results showed that this method could be well used for the simultaneous estimation of Ceftazidime and Sulbactam in plasma and combined formulation.

show abstract

Sulbactam plus Ampicillin: Interim Review of Efficacy and Safety for Therapeutic and Prophylactic Use

Cited by 40 publications

References 4 publications

Rational antibiotic therapy and the position of ampicillin/sulbactam

Rational antibiotic therapy and the position of ampicillin/sulbactam

Comparison of fixed concentration and fixed ratio options for dilution susceptibility testing of gram-negative bacilli to ampicillin and ampicillin/sulbactam

Development and Validation of High Performance Liquid Chromatographic Method for the Simultaneous Determination of Ceftazidime and Sulbactam in Spiked Plasma and Combined Dosage form-Zydotam

Contact Info

Product

Resources

About