Suitability of rodent tumor models for experimental PET with l-[1-11C]tyrosine and 2-[18F]fluoro-2-deoxy-d-glucose

Daemen, B.J.G.; Elsinga, Philip H.; Paans, Anne M. J.; Lemstra, Willy; Konings, Antonius W.T.; Vaalburg, W

doi:10.1016/0883-2897(91)90111-w

Cited by 8 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to those data, the study revealed a significant increase in serum methionine concentration in dogs possessing benign or malignant tumours. Increased serum tyrosine concentration in dogs from both groups with neoplastic changes remains in the agreement with studies on rat rhabdomyosarcoma model in which associations between tumour growth rate and tyrosine uptake were found (9). Moreover, hyperthermia-induced inhibition of tyrosine uptake correlated significantly with tumour regression (8).…”

Section: Discussionsupporting

confidence: 78%

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Brodzki

Szpetnar

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

The aim of the study was to determine serum free amino acid concentration in male dogs suffering from benign and malignant perianal tumours. Serum concentrations of cysteic acid, glutamic acid, glutamine, aspartic acid, glycine, γ-aminobutyric acid, tryptophan, methionine, arginine, taurine, threonine, tyrosine, alanine, valine, isoleucine, and leucine were significantly changed in dogs suffering from benign and/or malignant tumours when compared to the control group (P<0.05). Serum concentration of serine, phenylalanine, lysine and histidine was not influenced in dogs with neoplastic disease (P>0.05). The evaluation of serum free amino acid concentration, has shown that threonine, glutamic acid, alanine, valine, isoleucine, leucine, γ-aminobutyric acid, and glycine have the highest diagnostic and prognostic value in dogs suffering from benign and malignant perianal tumours. Highly diagnostic and prognostic value in relation to benign tumour growth was also found while evaluating branched chain and acidic groups of amino acids. Serine, phenylalanine, lysine, and histidine, as well as alkaline amino acids were proved not to have diagnostic and prognostic value in dogs with the tumours. Thus, the evaluation of free amino acid concentration may serve diagnostic purposes and help in tumour malignancy differentiation. The elaborated experimental model may be used in further studies on neoplastic disease development and monitoring of applied treatment efficiency.

show abstract

Section: Discussionsupporting

confidence: 78%

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Brodzki

Szpetnar

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

show abstract

Advances in Imaging Brain Cancer

Price

Waldman

2012

Emerging Concepts in Neuro-Oncology

View full text Add to dashboard Cite

Carbon-11 tyrosine PET for visualization and protein synthesis rate assessment of laryngeal and hypopharyngeal carcinomas

et al. 2002

View full text Add to dashboard Cite

Accurate assessment of tumour extent and lymph node involvement in squamous cell carcinomas of the head and neck region is essential for therapy planning. Unfortunately, conventional diagnostic examination and imaging techniques, which monitor tumours on the basis of anatomical parameters, have drawbacks in clinical practice. The aim of this study was to investigate the feasibility of L-[1-(11)C]-tyrosine (TYR) positron emission tomography (PET) for visualisation of squamous cell carcinoma of the larynx and hypopharynx and quantification of tumour activity by assessment of protein synthesis rate (PSR). Dynamic TYR PET was performed on 31 patients with T1-T4 laryngeal or hypopharyngeal carcinoma before therapy. Plasma activity of TYR, (11)CO(2) and (11)C-protein levels were measured, and PSRs were calculated for primary malignancies. All 31 laryngeal and hypopharyngeal tumours were visualised as a hotspot (sensitivity 100%). The median PSR of the tumours (2.06 nmol ml(-1) min(-1); range 0.72-6.96) was significantly higher ( P<0.001) than that of non-tumour (background) tissue (0.51 nmol ml(-1) min(-1); range 0.22-0.89). L-[1-(11)C]-Tyrosine PET appears to be a potential method for visualisation of primary laryngeal and hypopharyngeal tumours. In vivo quantification of tumour activity by assessment of PSR is possible and may have a future role in the therapy planning and therapy evaluation of laryngeal and hypopharyngeal tumours.

show abstract

Suitability of rodent tumor models for experimental PET with l-[1-11C]tyrosine and 2-[18F]fluoro-2-deoxy-d-glucose

Cited by 8 publications

References 13 publications

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Advances in Imaging Brain Cancer

Carbon-11 tyrosine PET for visualization and protein synthesis rate assessment of laryngeal and hypopharyngeal carcinomas

Contact Info

Product

Resources

About