Suitability of Forced Expiratory Volume in 1 Second/Forced Vital Capacity vs Percentage of Predicted Forced Expiratory Volume in 1 Second for the Classification of Asthma Severity in Adolescents

Dalen, Christine van; Harding, Elizabeth; Parkin, J.; Cheng, Shih-Lung; Pearce, Neil; Douwes, Jeroen

doi:10.1001/archpedi.162.12.1169

Cited by 41 publications

(29 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In many but not all of these studies, nonspecific hyperresponsiveness decreased after the intervention, consistent with a salutary effect of HACT on asthma. Another potential limitation in our study is the use of FEV1 as an end-point in children because it may be a poor measure of asthma control, especially in those of younger age [41,42]. Nevertheless, HACT has been used as ancillary treatment for asthma in the paediatric population, as the number of publications included in this analysis indicate.…”

Section: Discussionmentioning

confidence: 99%

High-altitude alpine therapy and lung function in asthma: Systematic review and meta-analysis

Vinnikov

Khafagy

Blanc

et al. 2016

6.2 Occupational and Environmental Health

View full text Add to dashboard Cite

We used meta-analysis to measure the effect of high-altitude climate therapy (HACT) on lung function outcomes in asthma, and systematically searched PubMed, Embase and www.elibrary.ru for publications appearing from 1970 to mid-2015. We included studies carried out with children or adults with an exposure of up to 12 weeks at an altitude of ⩾1500 m above sea level. Changes in forced expiratory volume in 1 s (FEV1), FEV1/vital capacity ratio or peak expiratory flow rate as the HACT intervention outcomes were analysed. We included data for 907 participants (age range 4-58 years) from 21 studies, altogether including 28 substrata based on asthma type or severity. Only three of 21 included studies had high quality, whereas 93% of substudies reported lung function improvement with an overall pooled standardised mean difference (SMD) of 0.53 (95% CI 0.43-0.62). The measured effect of HACT was greater in adults (SMD 0.75, 95% CI 0.63-0.88, n=14) than in children (SMD 0.24, 95% CI 0.09-0.38, n=14). Studies at altitude >2000 m above sea level yielded the same effect as those at lower altitude. Based on a cut-point of a 0.50 change in SMD to define a meaningful clinical difference, HACT appears to have efficacy as an intervention. This extent of benefit appears to be limited to adults with asthma. @ERSpublications High-altitude alpine therapy may be an effective intervention to improve lung function in patients with asthma

show abstract

Section: Discussionmentioning

confidence: 99%

High-altitude alpine therapy and lung function in asthma: Systematic review and meta-analysis

Vinnikov

Khafagy

Blanc

et al. 2016

6.2 Occupational and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Poor asthma control is associated with reduced lung function, increased risk of exacerbations and elevated FeNO [64,65,[73][74][75][76][77]. Changes in composite measures of asthma control reflect changes in the overall clinical assessment of asthma control by healthcare providers, changes in QoL, and the need to step up or step down therapy, suggesting that these composite measures have criteria validity [78,79].…”

Section: Clinical Tools: Symptoms Exacerbations and Qolmentioning

confidence: 99%

Monitoring asthma in children

et al. 2015

View full text Add to dashboard Cite

The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all components of asthma, such as symptoms, lung function, bronchial hyperresponsiveness and inflammation, may exist in various combinations in different individuals, to date there is limited evidence on how to integrate these for optimal monitoring of children with asthma. The aims of this ERS Task Force were to describe the current practise and give an overview of the best available evidence on how to monitor children with asthma.22 clinical and research experts reviewed the literature. A modified Delphi method and four Task Force meetings were used to reach a consensus.This statement summarises the literature on monitoring children with asthma. Available tools for monitoring children with asthma, such as clinical tools, lung function, bronchial responsiveness and inflammatory markers, are described as are the ways in which they may be used in children with asthma. Management-related issues, comorbidities and environmental factors are summarised.Despite considerable interest in monitoring asthma in children, for many aspects of monitoring asthma in children there is a substantial lack of evidence. @ERSpublications ERS statement summarising and discussing the available literature on monitoring children with asthma

show abstract

“…These differences are not unexpected, as a number of published studies showed that individual parameters of prebronchodilator spirometry were normal in the majority of children and adolescents with asthma. On the other hand, FEV 1 /FVC as an indicator of airflow limitation is more reliable as it declines with increasing asthma severity [36,37]. However, it is still possible that the observed differences were due to technical errors in performing spirometric measurements in the controls.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasma Soluble CTLA-4 with Lung Function and GenePolymorphism in Chinese Asthmatic Children

Chan

Tang²,

Leung³

et al. 2009

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Cytotoxic T lymphocyte antigen 4 (CTLA-4) is known to downregulate the T_H2 immune response. Recent studies have suggested an association of CTLA-4 polymorphisms with allergic diseases. We investigated the effects of single nucleotide polymorphisms (SNPs) of CTLA-4 on asthma traits and plasma sCTLA-4 in 298 Chinese asthmatic children and 175 controls. Methods: Plasma sCTLA-4, total and allergen-specific IgE concentrations were measured by enzyme immunoassay. Six SNPs, namely –1147CT, +49AG, CT60, JO31, JO30 and JO27_1, in CTLA-4 were genotyped by restriction fragment length polymorphism. Results: Plasma sCTLA-4 was negatively associated with FEV₁/FVC (r = –0.146, p = 0.036) among our asthmatic patients. Analysis of locus-locus interaction by generalized multifactor dimensionality reduction showed that –1147CT was the best model for plasma sCTLA-4 with a cross-validation consistency of 10 out of 10 and a prediction error of 40.9% (p < 0.001). Multivariate regression analysis confirmed the association between plasma sCTLA-4 concentration with –1147CT among the 6 SNPs tested (p = 0.002) after adjustment for gender and age. The plasma sCTLA-4 concentration was significantly lower in patients homozygous for the C allele than in T allele carriers (p = 0.001). There was also a significant association between the most common haplotypes with low sCTLA-4 in asthmatics. We could not find any significant association between plasma total IgE, atopy and lung function with the 6 SNPs after Bonferroni correction. Conclusions: Plasma sCTLA-4 is associated with lung function and –1147CT polymorphism in Chinese asthmatic children. This may help to identify CTLA-4 signaling as a potential therapeutic target in asthma.

show abstract

Suitability of Forced Expiratory Volume in 1 Second/Forced Vital Capacity vs Percentage of Predicted Forced Expiratory Volume in 1 Second for the Classification of Asthma Severity in Adolescents

Cited by 41 publications

References 14 publications

High-altitude alpine therapy and lung function in asthma: Systematic review and meta-analysis

High-altitude alpine therapy and lung function in asthma: Systematic review and meta-analysis

Monitoring asthma in children

Association of Plasma Soluble CTLA-4 with Lung Function and GenePolymorphism in Chinese Asthmatic Children

Contact Info

Product

Resources

About