Suitability of Chitosan Scaffolds with Carbon Nanotubes for Bone Defects Treated with Photobiomodulation

Silva, Samantha Ketelyn; Plepis, Ana Maria de Guzzi; Martins, Virgínia da Conceição Amaro; Horn, Marilia M.; Buchaim, Daniela Vieira; Buchaim, Rogério Leone; Pelegrine, André Antônio; Silva, Vinícius Rodrigues; Kudo, Mateus Hissashi Matsumoto; Fernandes, José Francisco Rebello; Nazari, Fabricio Montenegro; Cunha, Marcelo Rodrigues da

doi:10.3390/ijms23126503

Cited by 9 publications

(4 citation statements)

References 90 publications

(106 reference statements)

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“…Inappropriate wound treatment can cause serious complications and loss of function. CS and its derivatives demonstrate excellent properties, such as biocompatibility, osteoconduction, and a porous structure, and it promotes cell growth, hemostasis, broad-spectrum antibacterial activity, and tissue adhesion, which can be used as a wound healing accelerant [ 133 , 134 , 135 ] and are widely prepared into different forms of anticoagulant materials such as sponges, hydrogels, particles, bandages, and dressings [ 136 , 137 , 138 ]. When acting on the wound, these CS sponges, dressings, or particles can combine with tissue fluid exuded from injured skin to form a CS hydrogel, thereby promoting healing.…”

Section: Main Applications Of Cs and Its Chemically Modified Derivativesmentioning

confidence: 99%

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Chen

Jiang

et al. 2022

Marine Drugs

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Chitosan, which is derived from chitin, is the only known natural alkaline cationic polymer. Chitosan is a biological material that can significantly improve the living standard of the country. It has excellent properties such as good biodegradability, biocompatibility, and cell affinity, and has excellent biological activities such as antibacterial, antioxidant, and hemostasis. In recent years, the demand has increased significantly in many fields and has huge application potential. Due to the poor water solubility of chitosan, its wide application is limited. However, chemical modification of the chitosan matrix structure can improve its solubility and biological activity, thereby expanding its application range. The review covers the period from 1996 to 2022 and was elaborated by searching Google Scholar, PubMed, Elsevier, ACS publications, MDPI, Web of Science, Springer, and other databases. The various chemical modification methods of chitosan and its main activities and application research progress were reviewed. In general, the modification of chitosan and the application of its derivatives have had great progress, such as various reactions, optimization of conditions, new synthetic routes, and synthesis of various novel multifunctional chitosan derivatives. The chemical properties of modified chitosan are usually better than those of unmodified chitosan, so chitosan derivatives have been widely used and have more promising prospects. This paper aims to explore the latest progress in chitosan chemical modification technologies and analyze the application of chitosan and its derivatives in various fields, including pharmaceuticals and textiles, thus providing a basis for further development and utilization of chitosan.

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Section: Main Applications Of Cs and Its Chemically Modified Derivativesmentioning

confidence: 99%

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Chen

Jiang

et al. 2022

Marine Drugs

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“…Chitosan biomaterials containing graphene oxides were used as substrates for the generation of hydroxyapatite, which has a high elastic flexibility and tensile strength for bone tissue engineering applications [ 49 ]. Carbon nanotubes were also used as fillers in chitosan to increase flexibility, porosity, and mechanical strength of chitosan biomaterials for applications in bone tissue engineering [ 50 ]. The porous structure of the chitosan with an absorbable collagen sponge encourages osteoblast stem cells to attach to the surface to proliferate and differentiate promoting bone development.…”

Section: Reviewmentioning

confidence: 99%

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

Kim¹,

Murugan²,

Dalavi³

et al. 2022

Beilstein J. Nanotechnol.

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Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is important that the material used for bone tissue repair is simultaneously osteoconductive, osteoinductive, and osteogenic. To overcome this problem, researchers have tried several ways to develop different materials using chitosan-based nanocomposites of silver, copper, gold, zinc oxide, titanium oxide, carbon nanotubes, graphene oxide, and biosilica. The combination of materials helps in the expression of ideal bone formation genes of alkaline phosphatase, bone morphogenic protein, runt-related transcription factor-2, bone sialoprotein, and osteocalcin. In vitro and in vivo studies highlight the scientific findings of antibacterial activity, tissue integration, stiffness, mechanical strength, and degradation behaviour of composite materials for tissue engineering applications.

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“…are intensely developed worldwide as a means to address the sustainability criteria related to adaptability and resilience. They exhibit improved mechanical properties and elasticity [ 18 , 19 ], controlled porosity [ 20 ], and chemical stability [ 21 ], which render them more suitable to be used for long wear times in harsh environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

“…The available literature on polysaccharide-based composite hydrogels intended for removing pollutants from wastewater is overwhelmingly focused on the synthesis of new matrices and their testing in batch experiments to optimize the sorption conditions (pH, sorbent dose, contact time, equilibrium concentration, temperature) in simulated monocomponent aqueous media [ 19 , 21 , 23 , 24 , 25 , 26 , 27 ]. Recently, attention has been directed towards testing the polysaccharide hydrogel-type sorbents in complex matrices of pollutants (competitive investigations) and in column sorption experiments [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Composite Hydrogels as Sustainable Materials for Removal of Pollutants from Wastewater

Ghiorghiță¹,

Dinu²,

Lazăr³

et al. 2022

Molecules

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Nowadays, pollution has become the main bottleneck towards sustainable technological development due to its detrimental implications in human and ecosystem health. Removal of pollutants from the surrounding environment is a hot research area worldwide; diverse technologies and materials are being continuously developed. To this end, bio-based composite hydrogels as sorbents have received extensive attention in recent years because of advantages such as high adsorptive capacity, controllable mechanical properties, cost effectiveness, and potential for upscaling in continuous flow installations. In this review, we aim to provide an up-to-date analysis of the literature on recent accomplishments in the design of polysaccharide-based composite hydrogels for removal of heavy metal ions, dyes, and oxyanions from wastewater. The correlation between the constituent polysaccharides (chitosan, cellulose, alginate, starch, pectin, pullulan, xanthan, salecan, etc.), engineered composition (presence of other organic and/or inorganic components), and sorption conditions on the removal performance of addressed pollutants will be carefully scrutinized. Particular attention will be paid to the sustainability aspects in the selected studies, particularly to composite selectivity and reusability, as well as to their use in fixed-bed columns and real wastewater applications.

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Suitability of Chitosan Scaffolds with Carbon Nanotubes for Bone Defects Treated with Photobiomodulation

Cited by 9 publications

References 90 publications

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Progress in Research of Chitosan Chemical Modification Technologies and Their Applications

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

Polysaccharide-Based Composite Hydrogels as Sustainable Materials for Removal of Pollutants from Wastewater

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