SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes

Transplant Estimated Function

“…ssessing ␤-cell function in islet transplant recipients is difficult because no single measurement provides an exhaustive evaluation of the clinical success of the transplant (1)(2)(3)(4)(5). For this reason, a composite index that embodies the major aspects of function, the ␤-score, has been suggested recently (6).…”

Ameliorated pancreatic β cell dysfunction in type 2 diabetic patients treated with a sodium-glucose cotransporter 2 inhibitor ipragliflozin

“…The following calculations were performed with the use of these measurements: the C-peptide index (= [fasting C-peptide (ng/mL) / [fasting plasma glucose (mg/dL)] × 100) [14], secretory units of islets in transplantation (SUIT) (= 1485 × [fasting C-peptide (ng/mL) / ([fasting plasma glucose (mg/dL)] -61.8)) [15] -0.287 , (× 0.739 in females)) [16]. In a 24-hour urine test, urinary glucose, C-peptide, creatinine, sodium, albumin, β2-microglobulin, and liver-type fatty acid-binding protein (L-FABP) levels were evaluated.…”

Potential correlation between plasma total GIP levels and body mass index in Japanese patients with types 1 or 2 diabetes mellitus

“…Furthermore, Yabe et al reported that total GIP secretion in patients with T2DM was also similar to controls [6] and they [7] reported that postprandial GIP levels in drug-naïve patients with T2DM but not in sulfonylurea (SU)-treated patients was positively correlated with increments of plasma glucose (PG) using the area under the curve (AUC). These patients were also negatively correlated with fasting serum immunoreactive insulin (s-IRI), homeostasis model assessments for beta-cell function (HOMA-β), and secretory units in transplantation (SUIT) [8]. SU has little effect on GIP secretion.…”