Suicide attempt rate and the risk factors in young, first-episode and drug-naïve Chinese Han patients with major depressive disorder

Abstract

Background: In recent years, the rates of suicide among young people have been increasing, and major depressive disorder (MDD) is regarded to be its main cause. Many factors such as thyroid dysfunction and metabolic abnormalities are thought to mediate this process, but the conclusions are inconsistent. This study investigated the rate of suicide attempts and associated risk factors among young, first-episode and drug-naïve Chinese Han patients with MDD.Methods: A total of 917 patients with MDD (aged 18 ~ 35 years) were recruited. Demographic and clinical data were collected and thyroid function, fasting blood glucose and lipid profiles were measured. The Hamilton Depression Rating Scale-17 items (HAMD-17), Hamilton Anxiety Rating Scale (HAMA), positive symptom subscale of Positive and Negative Syndrome Scale (PANSS) and clinical global impression of severity scale (CGI-S) were adopted to assess depression, anxiety, psychotic symptoms and disease severity respectively. Results:The rate of suicide attempts was 19.5% in young MDD patients. There were significant differences in age (p = 0.003), education level (p = 0.001), age of onset (p = 0.004) and disease duration (p = 0.001) between patients with and without suicide attempts. Compared with patients without suicide attempts, patients with suicide attempts had significantly higher scores on the HAMD-17, HAMA, PANSS positive symptom subscale and CGI-S (all p < 0.001). Patients with suicide attempts had significantly higher levels of TSH (p < 0.001), TgAb (p = 0.004), TPOAb (p < 0.001), TG (p = 0.016), TC (p < 0.001), LDL (p < 0.001), and fasting glucose (p < 0.001), but significantly lower levels of HDL (p < 0.001). Logistic regression analysis showed that marital status (OR = 0.

Prevalence of suicide attempts and correlates among first-episode and untreated major depressive disorder patients with comorbid dyslipidemia of different ages of onset in a Chinese Han population: a large cross-sectional study

“…We noted an independent positive association between the CGI score and suicide attempts in patients with MDD with dyslipidemia of both early-adulthood onset and mid-adulthood onset. Gang Ye's study is consistent with our study showing that CGI is an independent risk factor for suicide attempts in patients with MDD [ 44 ]. The relationship between CGI and suicide attempts may be explained by the following factors: First, the CGI score represents the severity of the disease [ 45 ].…”

Model prediction of suicidal behavior in first hospitalization patients with major depression disorder: a cross-sectional study based on a large sample

“…Several studies with large samples of outpatient-treated MDD-diagnosed populations in Shanxi Province, China, also reported almost identical results to ours, and their authors also found that MDD subpopulations with SB with different clinical features had more severe anxiety symptoms, depressive symptoms, psychopathological symptoms, and more severe levels of metabolic parameters [28,21,[29][30][31]. Another report from the MDD population in Anhui, China, also reported similar results to ours [32].…”

Association between suicide attempts and anemia in late-life depression inpatients

“…Our results showed that serum folate and vitamin B 12 levels were signi cantly and negatively associated with suicide attempts in older patients with depression, whereas serum ferritin levels were not signi cantly associated with suicide attempts. Previous studies 30 found a positive association between low cholesterol levels and suicide attempts in patients with depression. However, no study con rmed whether there was an association between ferritin, folate, and vitamin B 12 and suicide attempts in older depressed patients.…”