Signaling through the erbB receptor family of tyrosine kinases contributes to the proliferation, differentiation, migration, and survival of a variety of cell types. Abnormalities in members of this receptor family have been shown to play a role in oncogenesis, thus making them attractive targets for anticancer treatments. PF-00299804 is a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor currently in phase I clinical trials. PF-00299804 is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members.

Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei. As a future high energy nuclear physics project, an Electron-ion collider in China (EicC) has been proposed. It will be constructed based on an upgraded heavy-ion accelerator, High Intensity heavy-ion Accelerator Facility (HIAF) which is currently under construction, together with a new electron ring. The proposed collider will provide highly polarized electrons (with a polarization of ∼80%) and protons (with a polarization of ∼70%) with variable center of mass energies from 15 to 20 GeV and the luminosity of (2–3) × 1033 cm−2 · s−1. Polarized deuterons and Helium-3, as well as unpolarized ion beams from Carbon to Uranium, will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region, including 3D tomography of nucleon; the partonic structure of nuclei and the parton interaction with the nuclear environment; the exotic states, especially those with heavy flavor quark contents. In addition, issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC. In order to achieve the above-mentioned physics goals, a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe. The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States. The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China.

The research presented in this paper shows that Waste Electrical and Electronic Equipment (WEEE) issues associated with home appliances, such as TV sets, refrigerators, washing machines, air conditioners, and personal computers, are linked in the WEEE flow and recycling systems and are important to matters of public policy and regulation. In this paper, the sources and generation of WEEE in China are identified, and WEEE volumes are calculated. The results show that recycling capacity must increase if the rising quantity of domestic WEEE is to be handled properly. Simultaneously, suitable WEEE treatment will generate large volumes of secondary resources. Environmental problems caused by the existing recycling processes have been investigated in a case study. Problems mainly stem from open burning of plastic-metal parts and from precious metals leaching techniques that utilize acids.The existing WEEE flow at the national level was investigated and described. It became obvious that a considerable amount of obsolete items are stored in homes and offices and have not yet entered the recycling system. The reuse of used appliances has become a high priority for WEEE collectors and dealers because reuse generates higher economic profits than simple material recovery. The results of a cost analysis of WEEE flow shows that management and collection costs significantly influence current WEEE management.Heated discussions are ongoing in political and administrative bodies as to whether extended producer responsibilities policies are promoting WEEE recycling and management. This paper also discusses future challenges and strategies for WEEE management in China.

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Application of transformation theory to underwater acoustics has been a challenging task because highly anisotropic density is unachievable in water. A possible strategy is to exploit anisotropic modulus rather than density, while has not been experimentally demonstrated. We present an annular underwater acoustic cloak designed from particular graded solid microstructures. The geometry tailored microstructures mimics meta-fluid with highly anisotropic modulus through substantially suppressed shear wave. Transient wave experiments are conducted with the cloak in a designed 2D underwater waveguide system and proved excellent cloaking performance for enclosed target over broadband frequency 9-15 kHz. This finding paves the way for controlling underwater acoustics using the structured anisotropic modulus meta-fluid.

Peer-to-peer (P2P) energy trading is one of the promising approaches for implementing decentralized electricity market paradigms. In the P2P trading, each actor negotiates directly with a set of trading partners. Since the physical network or grid is used for energy transfer, power losses are inevitable, and grid-related costs always occur during the P2P trading. A proper market clearing mechanism is required for the P2P energy trading between different producers and consumers. This paper proposes a decentralized market clearing mechanism for the P2P energy trading considering the privacy of the agents, power losses as well as the utilization fees for using the third party owned network. Grid-related costs in the P2P energy trading are considered by calculating the network utilization fees using an electrical distance approach. The simulation results are presented to verify the effectiveness of the proposed decentralized approach for market clearing in P2P energy trading.

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