Suggestive evidence for a functional association between mast cells and symphathetic nerves in meningeal membranes.

Ferrante, Fabio; Rícci, Alberto; Felici, Lavra; Cavallotti, Carlo; Amenta, Francesco

doi:10.1267/ahc.23.637

Cited by 15 publications

(5 citation statements)

References 25 publications

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“…Electrical stimulation of the superior cervical ganglion resulted in what they interpreted as an increase in 5HT fluorescence of mast cells, whereas the 5HT fluorescence decreased in bilaterally sympathectomized animals. Although our results and those of Ferrante et al (36) both support the idea that sympathetic fibres influence mast cells, the opinion regarding 5HT concentration within mast cells differs. We believe that the "degranulation" of mast cells ultimately results in a decrease rather than in an increase in mast cell 5HT concentration.…”

Section: Discussionsupporting

confidence: 50%

Influence of the Sympathetic Nervous System as Well as Trigeminal Sensory Fibres on Rat Dural Mast Cells

et al. 1991

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The dura mater has attracted considerable attention as an exquisitely sensitive tissue implicated as playing a role in various cephalalgias including vascular headache. Because of the potential clinical impact of the relationship/interaction of neural elements and mast cells the influence of sensory and autonomic nerve fibres on mast cells of the rat dura mater was studied. The trigeminal or superior cervical ganglion was electrically stimulated and the mast cells were examined. Wholemount supratentorial dural preparations were stained using berberine sulphate and the number of mast cells with intact vs dispersed granules counted. Unilateral stimulation of either ganglia resulted in a statistically significant increase in the percentage of mast cells with dispersed granules ipsilateral to the side of stimulation. These results support our idea that in addition to the trigeminal system the sympathetic nervous system must be considered as playing a role in the oedema pathophysiology of vascular headache.

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Section: Discussionsupporting

confidence: 50%

Influence of the Sympathetic Nervous System as Well as Trigeminal Sensory Fibres on Rat Dural Mast Cells

et al. 1991

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“…As already mentioned, there is a well-known spatial affinity between mast cells and nerves in mucosal tissues of the gastrointestinal tract (Stead et al, 1989), mesentery (Skofitsch et al, 1985), and airways (Undem et al, 1995), as well as in the bronchial ganglia (Myers et al, 1991) and meningeal membranes (Ferrante et al, 1990). Close approximations between mast cells and nerves have been documented in human skin (Walsh et al, 1991a;Pujic et al, 1998), human oral mucosa (Walsh et al, 1990c;Zhao et al, 1997), and rat palatal mucosa (Matsson et al, 1995).…”

Section: Mast Cells and The Neural-immune Networkmentioning

confidence: 89%

“…As will be discussed further below, the neuropeptides substance P and calcitonin gene-related peptide (CGRP) stimulate mast cell degranulation and cause cytokine release in vitro, and such mediators are implicated in the ongoing degranulation that is a feature of chronic inflammation at both the light (Walsh et al, 1995) and electron microscope levels (Jontell et al, 1986). There is strong evidence for functional interactions between mast cells and nerves (Blennerhassett et al, 1991;Walsh et al, 1991b;Marshall and Waserman, 1995;Theoharides, 1996), and spatial interactions between mast cells and nerves have been characterized in skin (Church et al, 1989;Walsh et al, 1991a;Murphy, 1993;Pujic et al, 1998), oral mucosa (Walsh et al, 1990c;Zhao et al, 1997;Bartold et al, 2000), and in the respiratory, urogenital, and gastrointestinal tracts (Heine and Forster, 1975;Skofitsch et al, 1985;Bienenstock et al, 1987;Stead et al, 1989;Ferrante et al, 1990;Myers et al, 1991;Undem et al, 1995).…”

Section: Mast Cell Mobilitymentioning

confidence: 99%

Mast Cells and Oral Inflammation

Walsh

2003

Critical Reviews in Oral Biology & Medicine

152

114

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Mast cells are mobile granule-containing secretory cells that are distributed preferentially about the microvascular endothelium in oral mucosa and dental pulp. The enzyme profile of mast cells in oral tissues resembles that of skin, with most mast cells expressing the serine proteases tryptase and chymase. Mast cells in oral tissues contain the pro-inflammatory cytokine tumour necrosis factor-␣ in their granules, and release of this promotes leukocyte infiltration during evolving inflammation in several conditions, including lichen planus, gingivitis, pulpitis, and periapical inflammation, through induction of endothelial-leukocyte adhesion molecules. Mast cell synthesis and release of other mediators exerts potent immunoregulatory effects on other cell types, while several T-lymphocyte-derived cytokines influence mast cell migration and mediator release. Mast cell proteases may contribute to alterations in basement membranes in inflammation in the oral cavity, such as the disruptions that allow cytotoxic lymphocytes to enter the epithelium in oral lichen planus. A close relationship exists among mast cells, neural elements, and laminin, and this explains the preferential distribution of mast cells in tissues. Mast cells are responsive to neuropeptides and, through their interaction with neural elements, form a neural immune network with Langerhans cells in mucosal tissues. This facilitates mast cell degranulation in response to a range of immunological and non-immunological stimuli. Because mast cells play a pivotal role in inflammation, therapies that target mast cell functions could have value in the treatment of chronic inflammatory disorders in the oral cavity.

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“…Previously, different authors studied cholinergic and catecholaminergic innervation of cerebral dura mater in man and in rat and suggested a possible functional relationship between nerve fibers and mast cells in the cerebral dura (Amenta et al, 1980;Blennerhassett et al, 1991;Cavallotti et al, 1978Cavallotti et al, , 1982Cavallotti et al, , 1986Cavallotti et al, , 1990Dimitriadou et al, 1990;Dimlich et al, 1991;Edvinsson et al, 1977;Ferrante et al, 1990;Heine and Forster, 1975;Keller et al, 1989). In fact, the close apposition of mast cells to sympathetic fluorescent nerve fibers may suggest, as reported by Dimitriadou et al (1991), a release from the mast cells of granules containing heparin, serotonin, and histamine in response to electrical stimulation of trigeminal axons, with a possible participation in the etiopathogenesis of neurogenic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Catecholaminergic and acetylcholine esterase containing nerves of cranial and spinal dura mater in humans and rodents

Artico

Cavallotti

2001

Microscopy Res & Technique

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The innervation of cranial and spinal dura mater in humans and rodents was studied by examining several dural zones (vascular, perivascular, intervascular) in different regions. Characterization and distribution of dural acetylcholinesterase-positive nerve fibers, catecholaminergic nerve fibers, and mast cells are analyzed and discussed. The results of chemical and surgical sympathectomy as well as the relationships between catecholaminergic nerve fibers and mast cells are studied. Our results are discussed in the light of possible implications in the physiopathology of dural algic syndromes including cephalalgia and spinal pain.

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Suggestive evidence for a functional association between mast cells and symphathetic nerves in meningeal membranes.

Cited by 15 publications

References 25 publications

Influence of the Sympathetic Nervous System as Well as Trigeminal Sensory Fibres on Rat Dural Mast Cells

Influence of the Sympathetic Nervous System as Well as Trigeminal Sensory Fibres on Rat Dural Mast Cells

Mast Cells and Oral Inflammation

Catecholaminergic and acetylcholine esterase containing nerves of cranial and spinal dura mater in humans and rodents

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