Suggestive evidence for a direct innervation of mucosal mast cells

Newson, B.; Dahlström, Annica; Enerbäck, Lennart; Ahlman, Håkan

doi:10.1016/0306-4522(83)90153-7

Cited by 232 publications

(89 citation statements)

References 17 publications

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“…In recent years some authors have hypothesized that mast cells located in various mammalian tissues such as skin, thymus, ileum, diaphragm, mesentery and pia mater are provided with an autonomic innervation (5, 14, 15, 18, 20-28, 32, 33). The above hypothesis was based on the observation of spatial relationships between mast cells and autonomic nerve terminals demonstrated both at the light and/or electron microscopic level (5,14,15,18,(20)(21)(22)(23)(24)(25)(26)(27)(28)32). However, the concept of innervation of a given structure requires not only spatial but functional relationships between nerve terminal and the effector cell.…”

Section: Discussionmentioning

confidence: 99%

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Suggestive evidence for a functional association between mast cells and symphathetic nerves in meningeal membranes.

Ferrante

Rícci

Felici

et al. 1990

Acta Histochem. Cytochem

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Section: Discussionmentioning

confidence: 99%

“…The possibility of an association between autonomic nerve endings and mast cells was also suggested by morphological studies that demonstrated relationships between the autonomic nervous system and mast cells in different organs of various species (14,15,18,26).…”

mentioning

confidence: 95%

Suggestive evidence for a functional association between mast cells and symphathetic nerves in meningeal membranes.

Ferrante

Rícci

Felici

et al. 1990

Acta Histochem. Cytochem

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“…In fact, microscopic patterns suggestive of true synapses between nerve fibres and mast cells have been described by Wiesner-Menzel, Schulz, Vakilzadeh & Czarnetzki (1981) in a subungual solitary glomus tumor in man, and by Heine & Forster (1975) in human subcutis and dog myocardium. Moreover, in a recent study (Newson et al 1983) mucosal mast cells from terminal ileum of rats demonstrated the presence of numerous nerve terminals or boutons seemingly in direct contact with their plasma membrane. Under the electron microscope, membrane specialization highly suggestive of true synapses was observed and the nature of the boutons identified as adrenergic and/or cholinergic by the shape and electron density or their vesicles (Newson et al 1983).…”

Section: Release Of Histamine By Vagal Stimulationmentioning

confidence: 93%

“…Moreover, in a recent study (Newson et al 1983) mucosal mast cells from terminal ileum of rats demonstrated the presence of numerous nerve terminals or boutons seemingly in direct contact with their plasma membrane. Under the electron microscope, membrane specialization highly suggestive of true synapses was observed and the nature of the boutons identified as adrenergic and/or cholinergic by the shape and electron density or their vesicles (Newson et al 1983). …”

Section: Release Of Histamine By Vagal Stimulationmentioning

confidence: 93%

The release of histamine by parasympathetic stimulation in guinea‐pig auricle and rat ileum.

Bani-Sacchi¹,

Barattini²,

Bianchi³

et al. 1986

The Journal of Physiology

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SUMMARY1. Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the responses to vagal or to electrical field stimulation.2. The responses to parasympathetic stimulation were depressed by atropine and by tetrodotoxin, and potentiated by eserine.3. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine and histamine, both in rat ileum and guinea-pig auricles.4. The release of histamine after parasympathetic stimulation did not exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli.5. In both preparations, atropine produced a significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine output.6. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine after parasympathetic stimulation.7. The possibility is discussed that acetylcholine released by parasympathetic stimulation would in turn evoke the secretion of histamine from tissue mast cells.

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“…In this context, nerve-mast cell interaction has been described in the skin and in the gastrointestinal (GI) and urinary tracts (4, 30, 33, 50). Early studies elegantly described the nonrandom spatial association of mast cells with nerves in a variety of tissues in which actual membrane-membrane contacts occur (11,22,32,44,47,48). In the GI tract, several studies have suggested that mast cell-nerve interaction has an important homeostatic role in the regulation of gut physiology as well pathophysiology (57).…”

mentioning

confidence: 99%

Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves

D’Andrea¹,

Saban²,

Gerard³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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-A spatial association between mast cells and nerves has been described in both the gastrointestinal and genitourinary tracts. However, the factors that influence the anatomic relationship between mast cells and nerves have not been completely defined. It has been suggested that the high-affinity receptor for substance P [neurokinin-1 (NK1)] might modulate this interaction. We therefore assessed mast cell-nerve relationships in tissues isolated from wild-type and NK1 receptor knockout (NK1 Ϫ/Ϫ ) mice. We now report that, in the complete absence of NK1 receptor expression, there is a significant increase in the number of mast cells without a change in the anatomic relationship between mast cell and nerves in stomach and bladder tissues at the light microscopic level. We next determined whether transplanted mast cells would maintain their spatial distribution, number, and contact with nerve elements. For this purpose, mast cell-deficient Kit W /Kit WϪv mice were reconstituted with wild-type or NK1 Ϫ/Ϫ bone marrow. No differences in mast cell-nerve contact were observed. These results suggest that NK1 receptor expression is important in the regulation of the number of mast cells but is not important in the interaction between mast cells and nerves. Furthermore, the interaction between mast cells and nerves is not mediated through NK1 receptor expression on the mast cell. Further studies are needed to determine the molecular pathway involved in mast cell migration and interaction with nerve elements, but the model of reconstitution of Kit W /Kit WϪv mice with mast cells derived from different genetically engineered mice is a useful approach to further explore these mechanisms. cystitis; substance P; disease animal model MAST CELLS ARE NORMALLY DISTRIBUTED throughout mucosal surfaces in proximity to blood vessels (21), lymphatics (56), peripheral nerves (22), and epithelial cells. This pattern of distribution facilitates the exposure of mast cells to stimuli, such as soluble protein, antigens (26), or neuropeptides (10), that can induce activation. Furthermore, it places the mast cell at the interface of potentially critical host-pathogen interactions (6, 28) and in turn makes their cell products available to a variety of cell types in the microenvironment, including sensory and autonomic nerves (22,47,48) and smooth muscle cells (16 -18).Spatial associations in biological systems are often indicative of functional interactions. In this context, nerve-mast cell interaction has been described in the skin and in the gastrointestinal (GI) and urinary tracts (4, 30, 33, 50). Early studies elegantly described the nonrandom spatial association of mast cells with nerves in a variety of tissues in which actual membrane-membrane contacts occur (11,22,32,44,47,48). In the GI tract, several studies have suggested that mast cell-nerve interaction has an important homeostatic role in the regulation of gut physiology as well pathophysiology (57). Studies that have utilized mast cell-deficient Kit W /Kit WϪv (Kit) mice have provide...

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Suggestive evidence for a direct innervation of mucosal mast cells

Cited by 232 publications

References 17 publications

Suggestive evidence for a functional association between mast cells and symphathetic nerves in meningeal membranes.

Suggestive evidence for a functional association between mast cells and symphathetic nerves in meningeal membranes.

The release of histamine by parasympathetic stimulation in guinea‐pig auricle and rat ileum.

Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves

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