A 75-year-old diabetic man with a cardiac history of pacemaker implantation and mechanical prosthetic valve (PV) replacement, also known for chronic osteitis of the first left metatarsophalangeal joint (MTP I), was treated with oral antibiotic on an outpatient basis with poor compliance when he developed intermittent fever (39.8°C) and left foot pain. Laboratory testing revealed a slight elevation of the white blood cell count (10.7 G/L) and a significant elevation of the C-reactive protein (235 mg/L). Hemocultures turned positive for multi-sensitive Staphylococcus aureus and Proteus mirabilis. A left foot CT showed MTP I osteoarthritis without collection. Transoesophageal echocardiography (TOE) showed no evidence of endocarditis. A double antibiotic regimen was started, but the patient developed persistent fever. Repeated TOE raised endocarditis suspicion. Because of a newly developed cough, a search for respiratory pathogens was performed and turned positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. An 18 F-FDG PET/CT was requested for investigating the suspicion of PV infection with a 72-h low-carbohydrate diet preparation.The 18 F-FDG PET maximum-intensity projection image shows (a) bilateral metabolic lung lesions, the foot infection (*), and one metabolically active draining sentinel lymph node (arrowhead). (b) Free-breathing lung CT and 18 F-FDG with hypermetabolic (SUV max 7.6 g/mL) focal ground-glass opacities with partial consolidation and mild bronchial dilatation with a peripheral distribution in the subpleural and periscissural regions of the apical and posterior segments of both upper lobes and right middle lobe, as previously described on CT [1]. (c) Hypermetabolic lymphadenopathies in the right lower paratracheal, subcarinal, and bilateral hilar stations (SUV max 6.