Sugar and ABA response pathways and the control of gene expression

Rook, Fred; Hadingham, Sophie; Li, Yunhai; Bevan, Michael W.

doi:10.1111/j.1365-3040.2005.01477.x

Cited by 223 publications

(177 citation statements)

References 76 publications

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“…Therefore, both fructose and glucose sensing depend on and interact with the same downstream ABA-and ethylene-signaling pathways. In seedlings, this sugar/ABA-signaling pathway represses photosynthesis genes such as CAB2 and PC (6,32,33). Importantly, CAB2 and PC are differentially regulated by glucose and fructose in the hxk1/gin2 and in the Ler expressing Cvi ANAC089, providing molecular evidence for separate glucose-and fructose-sensing systems.…”

Section: Discussionmentioning

confidence: 85%

Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Wind

Shi

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

114

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In living organisms sugars not only provide energy and carbon skeletons but also act as evolutionarily conserved signaling molecules. The three major soluble sugars in plants are sucrose, glucose, and fructose. Information on plant glucose and sucrose signaling is available, but to date no fructose-specific signaling pathway has been reported. In this study, sugar repression of seedling development was used to study fructose sensitivity in the Landsberg erecta (Ler)/Cape Verde Islands (Cvi) recombinant inbred line population, and eight fructose-sensing quantitative trait loci (QTLs) (FSQ1-8) were mapped. Among them, FSQ6 was confirmed to be a fructose-specific QTL by analyzing near-isogenic lines in which Cvi genomic fragments were introgressed in the Ler background. These results indicate the existence of a fructose-specific signaling pathway in Arabidopsis. Further analysis demonstrated that the FSQ6-associated fructose-signaling pathway functions independently of the hexokinase1 (HXK1) glucose sensor. Remarkably, fructosespecific FSQ6 downstream signaling interacts with abscisic acid (ABA)-and ethylene-signaling pathways, similar to HXK1-dependent glucose signaling. The Cvi allele of FSQ6 acts as a suppressor of fructose signaling. The FSQ6 gene was identified using mapbased cloning approach, and FSQ6 was shown to encode the transcription factor gene Arabidopsis NAC (petunia No apical meristem and Arabidopsis transcription activation factor 1, 2 and Cup-shaped cotyledon 2) domain containing protein 89 (ANAC089). The Cvi allele of FSQ6/ANAC089 is a gain-of-function allele caused by a premature stop in the third exon of the gene. The truncated Cvi FSQ6/ ANAC089 protein lacks a membrane association domain that is present in ANAC089 proteins from other Arabidopsis accessions. As a result, Cvi FSQ6/ANAC089 is constitutively active as a transcription factor in the nucleus. I n plants, sugars provide the energy and carbon skeletons needed for growth and in addition act as crucial signaling molecules that affect growth, development, and response to the (a)biotic environment (1-3). Plant cells harbor sugar-sensing and -signaling systems that regulate the expression of thousands of genes and control the metabolic processes needed for growth (2-4). These sugar-response systems are known to interact with other signaling pathways, such as those for light, phytohormones, stress, and nutrients (1).The neutral sugars sucrose, glucose, and fructose are central to metabolism in plants and in other organisms as well. So far, detailed information is available only on glucose sensing, and it has been shown that the hexokinase 1 (HXK1) enzyme acts as a glucose sensor (5, 6). Sucrose-specific signaling also was demonstrated because the effect of sucrose cannot be mimicked by glucose and/or fructose (7), but so far no information on sucrosesensing systems is available. A signaling function for fructose has been proposed (8, 9), but no convincing experimental evidence on such fructose-specific signaling is available.In Arabidopsis ea...

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Section: Discussionmentioning

confidence: 85%

Fructose sensitivity is suppressed in Arabidopsis by the transcription factor ANAC089 lacking the membrane-bound domain

Wind

Shi

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

114

View full text Add to dashboard Cite

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“…Renilla LUC activity did not vary significantly with co-introduction of the control vector. These results suggest that AtWRKY20 enhances expression of the ApL3 promoter, although SPF1 is known as a repressor in sweet potato (Rook et al, 2006).…”

Section: Effect Of Atwrky20 On the Expression Of The Apl3mentioning

confidence: 76%

“…A WRKY transcription factor in barley, SUSIBA2, has been shown to bind to W-box and sucrose-responsive elements (SUREs) (Grierson et al, 1994) in the promoter of the isoamylase1 gene as an activator (Sun et al, 2003). A WRKY transcription factor in sweet potato, SPF1, is able to bind to the sugarresponsive sporamin and β-amylase promoters (Ishiguro and Nakamura, 1994), and this suggests that SPF1 acts as a repressor (Rook et al, 2006). In A. thaliana, Masaki et al (2005) reported an activator of Spo min -LUC2 (ASML2; locus number At3g12890), which is a protein belonging to CCT (Constans, Constans-like, TOC1) domain proteins, functions as a transcriptional activator of ApL3, and expression of ASML2 gene is enhanced by sugars in A. thaliana.…”

mentioning

confidence: 99%

Activation of ADP-Glucose Pyrophosphorylase Gene Promoters by a WRKY Transcription Factor, AtWRKY20,in Arabidopsis thalianaL. and Sweet Potato (Ipomoea batatasLam.)

Nagata

Hara

Saitou

et al. 2012

Plant Production Science

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“…Many of these mutants also displayed ABA response mutant phenotypes, and some were allelic to ABA INSENSITIVE 4 (ABI4) and ABA DEFICIENT 2 (ABA2). 76 Thus forward-genetic screens have implicated a direct link from carbon availability to ABA signaling.…”

Section: Links Between the Plant Circadian Clock And Metabolismmentioning

confidence: 99%