Sudden unexpected death in an undiagnosed sickle disease

Pillai, Lalitha V.; Husainy, Saifuddin; Gosavi, Sameer; Vaidya, Narendra

doi:10.4103/0972-5229.17096

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…(Table 3) Most common portal of entry is respiratory tract (43.7%), followed by gastrointestinal tract (31%) and lastly genitourinary tract (6.2%) ( Table 4). In our study, male predominance and peak age group of death (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and the mean age at death of 30 years is similar to the mean age of death reported between 32 to 45 years in other study series. [10][11][12][13] 15 % cases of sudden death is reflect bias in case selection as these were all medico legal cases and sudden unexpected death is reason for medico legal case.…”

Section: Resultssupporting

confidence: 88%

“…11,12,17 Infection is the most common identifiable cause for acute chest syndrome and other important triggers for acute chest syndrome are asthma, pulmonary fat embolism, vaso-occlusive crisis (VOC) causing pulmonary vascular obstruction resulting in infarction of pulmonary parenchyma. [18][19][20][21] One case (2.5%) of Cholecystitis with cholelithiasis was reported as we have not received gall bladder in all cases. In the study by Manci EA et al, cholelithiasis was reported in 29% of cases.…”

Section: Resultsmentioning

confidence: 97%

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Autopsy findings and pattern of mortality in undiagnosed sickle cell disease patients

Gamit

Patel

Shah

et al. 2016

Int J Community Med Public Health

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Background: Sickle cell disease (SCD) has a high mortality rate with unexpected sudden death. So, the purpose of the study was to analyze clinical and/or autopsy findings at the time of death among sickle cell disease (SCD) patients. Methods: This is a retrospective study of SCD patients who died between January 2011 to December 2011 and the morphological evidence of the cause of death was studied in a tertiary care hospital of south Gujarat. The clinical data, including the age, gender, symptoms and the major autopsy findings and cause of death were obtained for each patient that included histopathological examination. Results: A total of 472 autopsies were performed, out of which sickled erythrocytes were detected in 40 cases. The mean age at death was 30 years and a male/female ratio of 3:1 and peak mortality was in the 2 nd and 3 rd decades of life. The common causes of death in this study include vaso-occlusive crisis (45%), infection (40%). The terminal infection was heralded by upper respiratory tract (43.7%) and by gastroenteritis (31.2%). Other causes of death included intracranial haemorrhage (2.5%) and cirrhosis (2.5%). Among the cases of SCD, 10% of deaths were nonhaemoglobinopathy related such as fall (accidental), organophosphorus poisoning and snake bite. Conclusion: This study is to precise analysis of causes of death is needed to focus and improve morbidity and mortality in sickle cell disease especially in highly prevalent area and will impact on the overall survival of these patients.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 97%

Autopsy findings and pattern of mortality in undiagnosed sickle cell disease patients

Gamit

Patel

Shah

et al. 2016

Int J Community Med Public Health

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“…Tendency for increasing splenic size is also associated with higher HbF. 5,6 Our patient had a short history of fever lasting for 3 days and was brought dead to our hospital. This fits the description of sickle cell crisis.…”

Section: Discussionmentioning

confidence: 99%

Sudden Death in Sickle Cell Disease: An Autopsy Diagnosis

Sheshanna¹,

Sethi²,

Prakash³

2017

The Journal of Medical Sciences

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Sickle cell disease is a common hereditary hemoglobinopathy with high prevalence in the central and northeastern regions of India. A 24-year-old male patient with 3 days' history of fever was brought dead to the hospital. Morphology showed clogging of blood vessels with sickled red blood cells (RBCs) in all the organs, and an autopsy diagnosis of sickle cell disease was made. As the cause may not be obvious in many cases, most patients remain undiagnosed. It is important to note the circumstances of death, gross finding, and histopathology, with hemoglobin electrophoresis if available, during autopsy to arrive at the diagnosis. This case is presented here to highlight this fact and draw attention to its pathology.

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“…In India, SCD is seen mainly in the tribal belts of Central zones comprised of Maharashtra, Madhya Pradesh, and Orissa. 4 Our patients were residents of Maharashtra. Only meagre histories were available for these patients.…”

mentioning

confidence: 99%