Autopsy findings and pattern of mortality in undiagnosed sickle cell disease patients

Abstract

Background: Sickle cell disease (SCD) has a high mortality rate with unexpected sudden death. So, the purpose of the study was to analyze clinical and/or autopsy findings at the time of death among sickle cell disease (SCD) patients. Methods: This is a retrospective study of SCD patients who died between January 2011 to December 2011 and the morphological evidence of the cause of death was studied in a tertiary care hospital of south Gujarat. The clinical data, including the age, gender, symptoms and the major autopsy findings and cause of death were obtained for each patient that included histopathological examination. Results: A total of 472 autopsies were performed, out of which sickled erythrocytes were detected in 40 cases. The mean age at death was 30 years and a male/female ratio of 3:1 and peak mortality was in the 2 nd and 3 rd decades of life. The common causes of death in this study include vaso-occlusive crisis (45%), infection (40%). The terminal infection was heralded by upper respiratory tract (43.7%) and by gastroenteritis (31.2%). Other causes of death included intracranial haemorrhage (2.5%) and cirrhosis (2.5%). Among the cases of SCD, 10% of deaths were nonhaemoglobinopathy related such as fall (accidental), organophosphorus poisoning and snake bite. Conclusion: This study is to precise analysis of causes of death is needed to focus and improve morbidity and mortality in sickle cell disease especially in highly prevalent area and will impact on the overall survival of these patients.

Spectrum of rare splenic lesions

“…6,2 One of the cases was of acute splenic sequestration whose overall incidence is 4.0% cases of total sickle cell anemia cases. 7 Rt isomerism with Asplenia which is present in two cases of fetal autopsies has an incidence of 1 in to 10000 birth. 8 Spleen is third most common organ involved in the Hydatid disease with World-wide incidence of 0.5 -4%.…”

The Politics of Knowledge Economy and Sustainability of Tribal Knowledge and Health in India

“…To the best of our knowledge, no such study has been undertaken before. There have been studies only on tribal health knowledge (Patil & Patil, 2005) and only on tribal health (Desai et al, 2017;Gamit et al, 2017;Kate, 2000), but no author has sought to link knowledge and health equity or their connection with the current paradigm of knowledge-economy. With this research gap in mind, our study will seek to fill in the gap in health policy studies.…”