Sudden onset hearing and visual loss: An unusual presenting manifestation of chronic phase chronic myeloid leukaemia

Tandon, S. K.; Yadav, Sanjeev; Nityanand, Soniya

doi:10.52768/2766-7820/1133

Cited by 2 publications

(12 citation statements)

References 20 publications

(33 reference statements)

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“…17–19 In our case, the patient had an extremely high WBC count of 780.72 × 10 9 /L and splenomegaly Schuffner 5. These data suggest that, among the multifactorial pathogenesis of CML, 5 , 6 , 8 , 10 , 17 , 22 the most notable in our case was hyperleukocytosis.…”

Section: Discussionsupporting

confidence: 53%

“…Hearing loss as a primary symptom of CML is uncommon. 3 , 5 , 6 , 17 , 18 , 20 Hearing loss in CML could be unilateral or bilateral SNHL, or it may begin as unilateral then progress to bilateral. 18 There have been only a few cases of juvenile CML in which SNHL was reported in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperleukocytosis can cause leukostasis and partial obstruction of the small-calibre labyrinthine artery (terminal branch of the basilar artery) that feeds the cochlea and vestibular system. 3 , 6 , 7 , 18 , 23 , 24 The theory of leukemic-cell adhesion to endothelial cells explains the mechanism of leukostasis. Leukemic cells may secret cytokines (TNF-α and IL-1) that activate endothelial cells to express specific adhesion receptors (selectins and VCAM-1).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, this temporary stasis may induce irreparable inner ear neuronal and vascular damage. 3 , 6 , 23 Brief periods of ischemia may cause hearing loss due to the lack of redundant blood supply to the cochlea. 12 The inner ear ischemia caused by leukostasis may lead to irreversible hearing loss.…”

Section: Discussionmentioning

confidence: 99%

“… 3 , 5 , 8 Unilateral or bilateral sensorineural hearing loss (SNHL), tinnitus, dizziness, and facial nerve paresis are among the symptoms. 3 , 18 Hearing loss has been linked to acute leukemias; however, it is uncommon in patients with CML, 3 , 5 , 6 , 17 , 18 , 20 especially in childhood; 15 it may develop later in the disease course than in acute leukemia. 5 This rarity is supported by a study that reported ocular symptoms and priapism as the most common leukostasis symptoms in juvenile CML.…”

Section: Introductionmentioning

confidence: 99%

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Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2–3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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Coexisting of hearing loss and chronic myeloid leukemia - A systematic literature review

Al-Ansari,

Woodman,

Mohammed Alghamdi

et al. 2024

F1000Res

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Objective This systematic literature review aimed to study the relationship between CML and hearing loss. Database review Chronic myeloid leukemia (CML) is a hematological malignancy associated with high levels of white blood cells (WBCs). Changes in otolaryngology are observed in CML. Methodology This systematic literature review of the literature was conducted by searching the MEDLINE/PubMed, Scopus, WPRIM, LILAC Sand SciELO databases. Studies published between 2013 and 2023 that met inclusion criteria were included. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used to evaluate the quality of studies. Results Of the 142 identified articles, 13 were included for final evaluation with a total sample size of 75 cases diagnosed with CML with hearing defect. CML patients with WBCs above 250 x 109/L were at higher risk of ototoxicity. Males accounted for 85% of cases; with a mean age of 38.9 years. Hearing loss as the first manifestation of CML was among 61.5% of cases, it was bilateral in 83.3% of cases, and in 90% of cases were irreversible defect. Conclusion Acute sudden hearing loss has been associated with high levels of WBC in patients with CML. Neither aggressive leukoreduction nor leukapheresis has positive effect on the reversibility of the hearing loss.

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Sudden onset hearing and visual loss: An unusual presenting manifestation of chronic phase chronic myeloid leukaemia

Cited by 2 publications

References 20 publications

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Coexisting of hearing loss and chronic myeloid leukemia - A systematic literature review

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