Sudden Increase in Intraocular Pressure as an Initial Manifestation of Myelodysplastic Syndrome

Wohlrab, Thomas-Michael; Pleyer, Uwe; Rohrbach, Jens Martin; Erb, Carl; Partsch, Michael

doi:10.1016/s0002-9394(14)71186-9

Cited by 9 publications

(3 citation statements)

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“…On the other hand, only a few reports can be found on the ocular complications of MDS. Although exophthalmos, 10 acute secondary glaucoma, 11 and choroidal tuberculosis 12 have been described in patients with MDS, no systematic study of ocular complications in MDS has been documented. In this report, we evaluated and compared the ocular complications in MDS patients and AML patients, because MDS are preleukemic disorders.…”

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confidence: 99%

Ocular Complications in Myelodysplastic Syndromes as Preleukemic Disorders

et al. 2005

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Ocular Complications in Myelodysplastic Syndromes as Preleukemic Disorders

et al. 2005

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“…Orbital inflammation with proptosis (Rouhiainen 1989) and exophthalmos with conjunctival chemosis, restricted motility and reduced visual acuity (Yamagami et al 1991) have been described but the pathogenesis was unclear in both cases. One patient was reported where infiltration of the retina, choroid and optic nerve by myelocytic and lymphocytic cells caused acute angle-closure glaucoma (Wohlrab et al 1995). Obviously, a variety of other symptoms can occur when there is leukemic infiltration of ocular structures.…”

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confidence: 99%

Bilateral necrotizing scleritis and blindness in the myelodysplastic syndrome presumably due to relapsing polychondritis

Loeffler¹,

McLean²

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The purpose of this study was to report a case of bilateral blindness, bilateral necrotizing scleritis, and bilateral deafness in a patient with myelodysplastic syndrome (MDS). In such a patient, the possibility of relapsing polychondritis (RPC) associated with MDS must be considered. Case Report/Methods: A 66-year-old patient suffered from myelodysplastic syndrome (MDS). Shortly before his death, he became bilaterally blind and deaf. A biopsy was taken from the conjunctiva and the bone marrow, and both eyes were obtained after death for further investigation. Findings of the clinical and laboratory work-up for the patient's hematologic disorder as well as an examination of the eyes by light microscopy and immunohistochemistry are presented. Results: Ocular sections showed a diffuse necrotizing scleritis with moderate uveitis and no identifiable infectious agent. Neither was there any evidence of a leukemic infiltration. -The deafness had been due to inner ear failure, and the patient died of a cardiac failure. Conclusions: Non-infectious scleritis associated with inner ear deafness is a strong indication of relapsing polychondritis (RPC). Furthermore, RPC can be associated with MDS. Thus, in addition to leukemic infiltration and infection involving ocular structures, ophthalmologists and otolargyngologists should be aware of the association between MDS and RPC and the potential complications.

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“…bei dessen Ubergang in eine AML, ist bisher in der Literatur selten beschrieben worden. Einmal konnte post Enukleation em choroidales Infiltrat histologisch gesichert werden (12). plastic syndrome showing its transition into acute myeloic leukemia however has been published in only few cases.…”

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