Choroidales Infiltrat auf dem Boden eines Myelodysplastischen Syndroms

Madjlessi, Faramarz; Dann, Katharina; Althaus, Christoph; Sundmacher, Rainer; Meckenstock, Guido

doi:10.1055/s-2008-1034944

Cited by 2 publications

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References 1 publication

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“…Serous retinal detachment is an uncommon presentation of new or relapsed leukemic disease, but it has been previously reported in cases of ALL and AML in the adult population. In the majority of reported cases of serous retinal detachment or choroidal infiltration, the systemic disease had been diagnosed prior to the development of ocular symptoms [3,4,5,6,7,8,9]. A review of the literature revealed only 5 cases of decreased vision and serous retinal detachment as initial presenting signs of new leukemia in an adult patient [10,11,12,13,14].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Unilateral Eye Findings: A Rare Herald of Acute Leukemia

et al. 2016

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Background/Aim: Unilateral choroidal infiltration as the initial manifestation of leukemic relapse in adults is rare, particularly after an extended period of remission. This report describes this unique ophthalmic presentation, highlights the associated diagnostic challenges, and reviews the literature. Methods: Two cases are described and an extensive literature review was conducted. Results: A 59-year-old male with acute lymphoid leukemia, in remission for 18 months, presented with unilateral scleritis, exudative retinal detachment, and choroidal thickening. A 57-year-old male with a history of acute myeloid leukemia, in remission for 4 years, presented with unilateral choroidal thickening leading to secondary angle closure. In both cases, there was a significant lag from the onset of eye symptoms to establishing a systemic diagnosis of acute leukemia, leading to a delay in definitive systemic treatment, despite a high suspicion of disease based on ophthalmic findings. Conclusions: These two cases illustrate the fundus findings consistent with leukemic choroidal infiltration that can represent the first sign of relapsed leukemia. The successful treatment of these patients hinges on collaboration between ophthalmologists and oncologists to optimize patient outcomes, highlighting the need for both groups to be aware of this rare ophthalmic presentation.

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Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Unilateral Eye Findings: A Rare Herald of Acute Leukemia

et al. 2016

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“… 1 2 It has been reported that leukemias are associated with choroidal infiltration. 12 13 14 Additionally, amaurosis fugax is has been reported in some ET patients that may be due episodic choroidal ischemic attacks. 3 Hence, ET may affect choroidal thickness.…”

Section: Discussionmentioning

confidence: 99%

Retinal vessel caliber, choroidal thickness and ocular pulse amplitude measurements in essential thrombocythemia

Pekel

Doğu

Sari

et al. 2016

Middle East Afr J Ophthalmol

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Purpose:The choroid and retina receive most of the blood that enter to the eye, and this uptake may be affected by essential thrombocythemia (ET) in which thrombosis and hemorrhage is common. This study compares choroidal thickness, retinal vascular caliber, and ocular pulse amplitude (OPA) measurements between patients with ET and healthy adults.Materials and Methods:Thirty-seven patients with ET and 37 age-sex-matched healthy adults were recruited in this cross-sectional and comparative study. Spectral-domain optical coherence tomography was used to measure the subfoveal choroidal thickness (SFCT) and retinal vascular caliber measurements. The Pascal dynamic contour tonometer was used for OPA and intraocular pressure (IOP) measurements. The independent samples t-test was used for comparison of measurements between the groups. Pearson's correlation coefficient analysis was used to detect correlations between the variables. A P < 0.05 was statistically significant.Results:SFCT, OPA, and IOP measurements were not statistically significant differences between the study group and the control group (P > 0.05, all comparisons). Blood platelet counts were not associated with choroidal thickness, OPA, and IOP (P > 0.05). Retinal arteriolar and venular calibers were statistically, significantly thicker in healthy controls when compared to the study group (P < 0.05).Conclusions:Our results indicate that choroidal thickness and pulsatile blood flow are not significantly affected in ET and under high blood platelet counts. Retinal arteriolar and venular calibers are thinner in ET when compared to age-sex matched healthy controls.

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Choroidales Infiltrat auf dem Boden eines Myelodysplastischen Syndroms

Abstract: To the best of our knowledge this is the first patient with a choroidal infiltration as the initial sign of progression of myelodysplastic syndrome to acute myeloic leukemia. Realizing this possibility helps for an early diagnosis and rapid therapy which is so crucial in prolonging life.

Cited by 2 publications

References 1 publication

Unilateral Eye Findings: A Rare Herald of Acute Leukemia

Unilateral Eye Findings: A Rare Herald of Acute Leukemia

Retinal vessel caliber, choroidal thickness and ocular pulse amplitude measurements in essential thrombocythemia

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