Sudden cardiac death in hypertrophic cardiomyopathy: time to change the narrative

Elliott, Perry

doi:10.1093/eurheartj/ehab608

Cited by 13 publications

(2 citation statements)

References 12 publications

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“…Cardiac arrest (CA) presents with the highest mortality rate among cardiovascular and cerebrovascular diseases and is one of the most critical situations in the field of public health and clinical medicine (1,2). Although patients with CA recover spontaneous circulation after having effective cardiopulmonary resuscitation (CPR), they still have various degrees of coma and multiple organ dysfunction (i.e., postcardiac arrest syndrome [PCAS]) (3,4).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Nitrosative Stress Attenuates Myocardial Injury and Improves Outcomes after Cardiac Arrest and Resuscitation

Wang

Yuan

Cao

et al. 2022

Shock

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Objectives:Nitrosative stress is widely involved in cell injury via inducing the nitration modification of a variety of proteins. This study aimed to investigate whether inhibition of nitrosative stress attenuated myocardial injury and improved outcomes in a rat model of cardiac arrest (CA) and cardiopulmonary resuscitation (CPR).Methods:Adult male Wistar rats were subjected to asphyxia-induced cardiac arrest and subsequently resuscitation. One minute after return of spontaneous circulation (ROSC), rats were randomized and administered the nitrosative stress inhibitor, FeTMPyP (1 or 3 mg/kg), or normal saline as a placebo. 3-Nitrotyrosine (3-NT), mean arterial pressure (MAP), heart rate (HR), mortality, electrocardiogram (ECG), left ventricular ejection fraction (EF) and fractional shortening (FS), and levels of myocardial apoptosis were evaluated. The concentrations of lactate, creatine kinase MB isoenzyme (CK-MB), and angiotensin II (Ang II), were measured in blood samples.Results:3-NT level was significantly increased in the heart after ROSC. Administration of FeTMPyP (1 or 3 mg/kg) attenuated the increase of 3-NT in the myocardium. Inhibition of nitrosative stress improved survival and attenuated CA/CPR-induced reperfusion injury by maintaining the stability of MAP and HR, and reducing the accumulation of lactic acid. Post-cardiac arrest rats had higher serum CK-MB and Ang II than healthy rats, while EF and FS were lower in healthy rats. Inhibition of nitrosative stress not only alleviated ischemic heart injury but also reduced the occurrence of CA/CPR-induced of arrhythmias. Moreover, nitrosative stress mediated the upregulation of Cleaved caspase-3 and downregulation Bcl-2, which was abolished by FeTMPyP.Conclusions:Inhibition of nitrosative stress is a novel molecular target to alleviate myocardial injury and improve outcomes in a rat model of CA/CPR.

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Section: Introductionmentioning

confidence: 99%

Inhibition of Nitrosative Stress Attenuates Myocardial Injury and Improves Outcomes after Cardiac Arrest and Resuscitation

Wang

Yuan

Cao

et al. 2022

Shock

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“…Among them, HCM is usually witnessed with obvious heredity ( 15 ). At present, more and more scholars have pointed out the importance of gene detection in HCM risk stratification ( 16 ). Our study identified TNNC1, TCAP and MYL2 as the risk genes for SD in HCM.…”

Section: Discussionmentioning

confidence: 99%

Using machine learning to find genes associated with sudden death

Zhou

Cai²,

He³

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveTo search for significant biomarkers associated with sudden death (SD).MethodsDifferential genes were screened by comparing the whole blood samples from 15 cases of accidental death (AD) and 88 cases of SD. The protein-protein interaction (PPI) network selects core genes that interact most frequently. Machine learning is applied to find characteristic genes related to SD. The CIBERSORT method was used to explore the immune-microenvironment changes.ResultsA total of 10 core genes (MYL1, TNNC2, TNNT3, TCAP, TNNC1, TPM2, MYL2, TNNI1, ACTA1, CKM) were obtained and they were mainly related to myocarditis, hypertrophic myocarditis and dilated cardiomyopathy (DCM). Characteristic genes of MYL2 and TNNT3 associated with SD were established by machine learning. There was no significant change in the immune-microenvironment before and after SD.ConclusionDetecting characteristic genes is helpful to identify patients at high risk of SD and speculate the cause of death.

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Current perspectives of sudden cardiac death management in hypertrophic cardiomyopathy

Pu,

Li,

et al. 2023

Heart Fail Rev

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Sudden cardiac death in hypertrophic cardiomyopathy: time to change the narrative

Cited by 13 publications

References 12 publications

Inhibition of Nitrosative Stress Attenuates Myocardial Injury and Improves Outcomes after Cardiac Arrest and Resuscitation

Inhibition of Nitrosative Stress Attenuates Myocardial Injury and Improves Outcomes after Cardiac Arrest and Resuscitation

Using machine learning to find genes associated with sudden death

Current perspectives of sudden cardiac death management in hypertrophic cardiomyopathy

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