Suction Blister Epidermal Grafting for Management of Eyelid Vitiligo: Special Considerations

Nanda, Soni; Relhan, Vineet; Grover, Chander; Reddy, B.S.N.

doi:10.1111/j.1524-4725.2006.32078.x

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…Epidermal grafts have been successfully used for lip vitiligo (Gupta et al., 2007); complete repigmentation was observed in 23 of 25 patients (92%), but hyperpigmentation developed in 12 subjects (Gupta et al., 2006). Delicate areas such as eyelids were treated in six patients with excellent results (Nanda et al., 2006). In a case report of segmental vitiligo with surgical failure, repigmentation was complete when NB UVB and oral corticosteroids were added to the grafting procedure (Lee et al., 2007).…”

Section: Surgical Methodsmentioning

confidence: 99%

Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

136

121

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SummaryTreatment for vitiligo is difficult and prolonged. Nevertheless, at present considerable knowledge accumulated during several decades on the pathogenic mechanisms, revealed important clues for designing new strategies to improve vitiligo depigmentation. With available medical therapies, high repigmentation percentages mostly on facial and neck lesions are achieved, although they are less effective on trunk and limbs and poor on the acral parts of the extremities. Narrow band UVB and psoralens and UVA are the two most important treatments for generalized vitiligo affecting more than 10-20% of the cutaneous surface, and topical corticosteroids, or calcineurin inhibitors are the most valuable treatments for localized vitiligo. Persistence of achieved regimentation is variable and an undefined percentage of patients may have variable recurrence.When vitiligo becomes refractory, surgical methods may improve depigmentation as effectively as with medical therapy; in segmental (unilateral) or long standing, non-segmental (bilateral) stable vitiligo, repigmentation with surgical methods is usually permanent.

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Section: Surgical Methodsmentioning

confidence: 99%

Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

136

121

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“…Repigmentation is faster and the color match is very good, especially over the lips,[28] eyelids[29] and areola. One group observed that the color match was better with punch grafting over the lips as compared to SBG, however, the number of patients were small.…”

Section: Advantagesmentioning

confidence: 99%

Tissue grafts in vitiligo surgery - past, present, and future

2009

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Vitiligo, characterized by depigmented macules is a common disorder with a high psychosocial impact, particularly in darker skins. Surgical methods become important in cases where medical therapy fails to cause repigmentation or in cases of segmental vitiligo where the response to surgery is excellent. The basic principle of surgical treatment is autologous grafting of viable melanocytes from pigmented donor skin to recipient vitiliginous areas. Various grafting methods have been described including tissue grafts and cellular grafts. Stability of the disease is the most important criterion to obtain a successful outcome. Counseling of the patient regarding the outcome is vital before surgery. The technique and followup management of the tissue grafts has been described in detail in this review.

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“…Certain areas such as the fingers and toes, palms and soles, lips, eyelids, nipples and areola, elbows and knees, and genitals are considered difficult to treat sites and require special precautions in therapy [29,40,41]. However, noncultured cellular transplantation does not require any special precautions to treat these sites [42].…”

Section: Anatomical Locationsmentioning

confidence: 99%

Surgical management of vitiligo

Mulekar¹

2010

Expert Review of Dermatology

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Vitiligo is a common condition characterized by hypopigmented and/or depigmented spots on the skin, affecting approximately 1-2% of the world population. Until approximately 30 years ago, it was exclusively treated by medical therapies. The most commonly used medical therapies include topical steroids, calcineurin inhibitors and phototherapy. Lesions on the face and neck respond the best to medical therapies, followed by lesions on the proximal extremities and trunk, while those distributed over acral parts of extremities and nonhairy areas, such as the wrist, feet and male genitals, respond poorly. Surgical methods complement medical therapies by providing melanocytes to these refractory lesions, and are indicated for unilateral segmental and clinically stable bilateral vitiligo, refractory to medical treatment. Tissue-grafting methods include minigrafting or punch grafting, epidermal grafting and split thickness grafting. These methods use full-thickness punch grafts, roof of epidermal blisters and shave biopsy samples, respectively, as the source of melanocytes. Cellular grafting includes noncultured and cultured melanocytes/keratinocytes suspensions obtained from trypsinizing the shaved skin biopsy sample as a source of melanocytes. Recent advances over the years have enabled dermatologists to treat extensive areas located on any anatomic site in a single operative session by surgical intervention. The purpose of this review is to describe the selection criteria for the surgical treatment, their utility and limitations in the various types of vitiligo.

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Suction Blister Epidermal Grafting for Management of Eyelid Vitiligo: Special Considerations

Abstract: If carried out properly, suction blister technique is the procedure of choice for cosmetically important sites like eyelids.

Cited by 14 publications

References 15 publications

Update on skin repigmentation therapies in vitiligo

Update on skin repigmentation therapies in vitiligo

Tissue grafts in vitiligo surgery - past, present, and future

Surgical management of vitiligo

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