Sucrose diester of aryldihydronaphthalene-type lignans from Echium angustifolium Mill. and their antitumor activity

Antioxidant potential and LC/MS metabolic profile of anticancer fractions from Echium angustifolium Mill. aerial parts

“…These values of IC 50 were comparable to those induced by doxorubicin (4.57 ± 0.5 and 3.73 ± 0.6 µg/ml against HEPG2 and HCT116, respectively). The antitumor activity of two previously isolated lignans from E. angustifolium against breast and liver cell cancer lines (MCF7 and HepG2) was proved, and they displayed promising in vitro antitumor activity lignans (El-Rokh et al, 2018b). This previous report was found to be consistent with the above results, as different lignans were detected in the tested fraction (Ea-DfD) by the LC/ MS technique.…”

“…Echium angustifolium Mill., a member of the Boraginaceae family, is a perennial plant growing in the northwestern coastal region of Egypt and is utilized for various uses such as grazing, medical, and fuel purposes (Bidak et al, 2015). The leaves of E. angustifolium were used traditionally in the Arab region for hepatitis, jaundice, kidney conditions (especially stones), and skin problems (Ghazanfar, 1994), whereas the previous biological studies reported the antitumor activity for the plant's lignans (El-Rokh et al, 2018b), the insecticidal activity against Aphis craccivora for the volatile oil of the plant (El-Rokh et al, 2018a), the analgesic and antioxidant activity (Al-Rimawia et al, 2020;Eruygur et al, 2012), the wound healing activity (Eruygur et al, 2016), and its use in treating ciguatoxin toxicity and inflammation from snake venom (Sadawe et al, 2020).…”

“…The total fat content was determined in the seeds, and the unsaturated fatty acids (linoleic, α-linoleic, γ-linolenic, and stearidonic acids) were identified as the predominant components (Özcan, 2008). Additionally, analysis of the butanol fraction of the whole plant (fractionated from the methanolic extract) resulted in the identification of five lignans, namely echiumins A-D and trigonotin A, where the plant was collected from Abo-Mandor at the Rosetta branch of the River Nile, Egypt (El-Rokh et al, 2018b). Moreover, six naphthoquinones were identified from the roots' extract (Eruygur, 2018).…”

“…Since then, E. angustifolium has been considered an edible plant for animals, and the plant extracts were not examined previously for their in vitro anticancer activities except some pure isolated lignans against the HepG2 and MCF7 cancer cell lines (El-Rokh et al, 2018b). Additionally, some other plant constituents might contribute to this activity.…”

Montbresides A–D: antibacterial p-coumaroyl esters of a new sucrose-based tetrasaccharide from Crocosmia × crocosmiiflora (montbretia) flowers

“…Correlations of Rha-H2 (δ 5.24), Rha-H3 (δ 5.03), Fru-H1 (δ 4.22, 4.29) and Fru-H6 (δ 4.41, 4.49) to acetyl carbonyl signals (δ 171.8, 172.3×2, 172.7)showed that the the O-acetyl groups were linked to Rha-C2, Rha-C3, Fru-C1 and Fru-C6.Furthermore, Fru-H3 (δ 5.64) and Glc-A-H4 (δ 5.00) show long-range correlations to the carbonyl signals of coumaroyl groups A (δ 167.8) and B (δ 168.5) respectively, showing that the O-coumaroyl groups are linked to Fru-C3 and Glc-A-C4[9].…”