Sucrose and non-nutritive sucking for the relief of pain in screening for retinopathy of prematurity: A randomised controlled trial

Boyle, E.M.; Freer, Yvonne; Khan-Orakzai, Z.; Watkinson, Michael; Wright, Elizabeth C.; Ainsworth, John R.; McIntosh, Nathalie

doi:10.1016/j.acpain.2006.08.035

Cited by 29 publications

(37 citation statements)

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“…Secara umum skrining berjalan dengan baik, tidak ditemukan adanya efek samping sistemik seperti peningkatan denyut jantung, tekanan darah, gangguan respirasi ataupun gangguan gastrointestinal, seperti yang dilaporkan pada penelitian sebelumnya. [16][17][18] Pemeriksaan dilakukan pada bayi yang dibedong dan telah disusukan. Bayi diberikan tetes mata tropicamide 1% beberapa jam sebelumnya dan phenylephrine 2,5% setengah jam sebelum pemeriksaan mata dilakukan.…”

Section: Pembahasanunclassified

Skrining Retinopathy of Prematuritydi Rumah Sakit dengan Fasilitas Terbatas

Dewi¹,

Tuhusula²,

Rohsiswatmo³

2016

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Retinopathy of prematurity (ROP) adalah penyakit vasoproliferatif pada retina yang dihubungkan dengan kelahiran prematur. Telah diketahui bahwa ROP merupakan penyebab gangguan penglihatan utama pada bayi prematur yang sebenarnya sangat mungkin untuk dihindari. Gangguan penglihatan ini bersifat permanen dan mempunyai pengaruh besar terhadap kualitas hidup pasien. Sebagian besar ROP derajat rendah dapat sembuh sendiri, walaupun demikian retina dapat lepas dan terjadi kebutaan. Skrining terhadap ROP telah dianjurkan di banyak negara.

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Section: Pembahasanunclassified

Skrining Retinopathy of Prematuritydi Rumah Sakit dengan Fasilitas Terbatas

Dewi¹,

Tuhusula²,

Rohsiswatmo³

2016

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“…Although results of a meta-analysis of 4 studies conducted during eye examination showed sucrose significantly reduced Premature Infant Pain Profile (PIPP) scores, the effects were small and inconsistent between individual studies. [51][52][53][54] In addition, a 50% glucose solution was no more effective than water during circumcision, 55 and a single dose of sucrose failed to significantly reduce crying in older infants undergoing urethral catheterization 56 and venepuncture. 57 The reduced effectiveness of sweet solutions in these more invasive procedures of relatively long duration may be due to the shortlasting effects of a single dose given 2 minutes before the procedures.…”

Section: Human Model Studiesmentioning

confidence: 99%

Sucrose for Procedural Pain Management in Infants

2012

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The use of oral sucrose has been the most extensively studied pain intervention in newborn care to date. More than 150 published studies relating to sweet-taste-induced calming and analgesia in human infants have been identified, of which 100 (65%) include sucrose. With only a few exceptions, sucrose, glucose, or other sweet solutions reduced pain responses during commonly performed painful procedures in diverse populations of infants up to 12 months of age. Sucrose has been widely recommended for routine use during painful procedures in newborn and young infants, yet these recommendations have not been translated into consistent use in clinical practice. One reason may be related to important knowledge and research gaps concerning analgesic effects of sucrose. Notably, the mechanism of sweet-taste-induced analgesia is still not precisely understood, which has implications for using research evidence in practice. The aim of this article is to review what is known about the mechanisms of sucrose-induced analgesia; highlight existing evidence, knowledge gaps, and current controversies; and provide directions for future research and practice. Pediatrics 2012;130:918-925

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“…Boyle et al 21 found that sucrose in addition to the pacifier gave no additional benefit, and we did not allow the use of sucrose for any infant during these ROP screenings. We found that proparacaine use significantly lowered PIPP scores at 1 min, but we did not find any difference in scores at 5 min after the examination.…”

Section: Discussionmentioning

confidence: 99%

“…We also sought to examine the effect of GA by comparing the post-examination PIPP scores between the first and second examinations, regardless of the type of drops used. Other measures to reduce distress and pain in neonates such as pacifiers without sucrose, and swaddling 21,22 have shown to be effective, so all babies were swaddled and offered non-nutritive pacifiers during all screening events. Studies regarding the benefit of sucrose during painful procedures have had varied results.…”

Section: Discussionmentioning

confidence: 99%

Effect of topical anesthesia and age on pain scores during retinopathy of prematurity screening

2010

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Objective: The efficacy of topical anesthesia during retinopathy of prematurity (ROP) screening has been a controversial issue. To determine the efficacy of proparacaine eye drops (0.5%), we compared the Premature Infant Pain Profile (PIPP) scores in 40 preterm infants undergoing ROP screening.Study Design: Prospective randomized double masked cross-over clinical trial. The study was conducted in the neonatal intensive units for infants undergoing routine ROP screening exams. Baseline PIPP scores and post-examination PIPP scores at 1 and 5 min were compared for: (1) those receiving saline vs proparacaine eye drops (2) first ROP screening vs second ROP screening, regardless of the type of eye drops used. Wilcoxon signed-ranks test was used to pair pain scores.Result: Forty preterm infants were included in the study. Mean gestational age (GA) at first and second examinations was 33.3 and 35.3 weeks, respectively. Proparacaine use significantly lowered mean PIPP scores (P ¼ 0.027) and delta scores (P ¼ 0.013) at 1 min after examination, but there was no difference at 5 min after examination. Second examinations showed significantly lower mean PIPP scores after examination (1 min (P ¼ 0.003) and 5 min (P ¼ 0.025)), regardless of the type of drop used.Conclusion: Proparacaine eye drops offer significant relief of pain that is apparently short lived. Significantly lower PIPP scores at second ROP examinations suggested that infants of older GA may have a greater ability to tolerate ROP screening. We recommend the use of proparacaine eye drops for the short term, immediate relief of pain during ROP screening in preterm infants of lesser GA.

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Sucrose and non-nutritive sucking for the relief of pain in screening for retinopathy of prematurity: A randomised controlled trial

Cited by 29 publications

References 0 publications

Skrining Retinopathy of Prematuritydi Rumah Sakit dengan Fasilitas Terbatas

Skrining Retinopathy of Prematuritydi Rumah Sakit dengan Fasilitas Terbatas

Sucrose for Procedural Pain Management in Infants

Effect of topical anesthesia and age on pain scores during retinopathy of prematurity screening

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