Succinylcholine-Induced Hyperkalemia in Patients with Renal Failure: An Old Question Revisited

Thapa, Sushma; Brull, Sorin J.

doi:10.1213/00000539-200007000-00044

Cited by 58 publications

(28 citation statements)

References 34 publications

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“…The increase in plasma potassium is transient but nevertheless potentially dangerous in the setting of chronic hyperkalemia and kidney disease. An exaggerated increase in potassium levels due to succinylcholine has been reported in such conditions as burns, spinal cord injury and neuromuscular diseases [37].…”

Section: Medications Membrane Transporter Effectsmentioning

confidence: 96%

Postoperative hyperkalemia

Ayach

Nappo

Paugh‐Miller

et al. 2015

European Journal of Internal Medicine

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Hyperkalemia occurs frequently in hospitalized patients and is of particular concern for those who have undergone surgery, with postoperative care provided by clinicians of many disciplines. This review describes the normal physiology and how multiple perioperative factors can disrupt potassium homeostasis and lead to severe elevations in plasma potassium concentration. The pathophysiologic basis of diverse causes of hyperkalemia was used to broadly classify etiologies into those with altered potassium distribution (e.g. increased potassium release from cells or other transcellular shifts), reduced urinary excretion (e.g. reduced sodium delivery, volume depletion, and hypoaldosteronism), or an exogenous potassium load (e.g. blood transfusions). Surgical conditions of particular concern involve: rhabdomyolysis from malpositioning, trauma or medications; bariatric surgery; vascular procedures with tissue ischemia; acidosis; hypovolemia; and volume or blood product resuscitation. Certain acute conditions and chronic co-morbidities present particular risk. These include chronic kidney disease, diabetes mellitus, many outpatient preoperative medications (e.g. beta blockers, salt substitutes), and inpatient agents (e.g. succinylcholine, hyperosmolar volume expanders). Clinicians need to be aware of these pathophysiologic mechanisms for developing perioperative hyperkalemia as many of the risks can be minimized or avoided.

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Section: Medications Membrane Transporter Effectsmentioning

confidence: 96%

Postoperative hyperkalemia

Ayach

Nappo

Paugh‐Miller

et al. 2015

European Journal of Internal Medicine

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“…Como ya hemos adelantado, la hiperkalemia y las arritmias por ella facilitadas constituyen la vía final común de gran parte de las complicaciones asociadas a la SC 2,5,9,19,20,30 . Aunque en nuestra serie, con un corte definido en 5,5 mEq/L, solo encontramos 39 estancias con hiperpotasemia documentada, no debemos olvidar que se han publicado casos de parada cardiaca tras SC con niveles basales de potasio normales 24,31 .…”

Section: Discussionunclassified

Prevalencia de contraindicaciones a succinilcolina en unidades de cuidados intensivos

et al. 2015

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“…In contrast, IV succinylcholine does not cause an exaggerated acute hyperkalemic response in the presence of chronic hyperkalemia unless a motor neuropathy is present. Indeed, patients with chronic renal failure are not at increased risk for hyperkalemia after succinylcholine [28]. Similarly, children with cerebral palsy are not at risk for hyperkalemia after succinylcholine [29].…”

Section: -Hypoxiamentioning

confidence: 99%

Cardiac Arrest in Children

Lampugnani

Lerman

Grasso

et al. 2017

Curr Anesthesiol Rep

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Perioperative cardiac arrest in children is a rare but catastrophic adverse event. It is difficult to investigate the incidence, risk factors, causes, and outcomes from these events, but the exercise is extremely useful in order to develop strategies to prevent it. Recent data identified several major risk factors for cardiac arrest in children: American Society of Anesthesiologists (ASA) physical status >3, age <1 year, and lack of specific pediatric experience by the healthcare providers. Since 1994, when the Perioperative Cardiac Arrest (POCA) Registry was created, the frequency of medicationrelated causes of cardiac arrest in children has decreased while the frequency of respiratory and cardiovascular causes has increased. The International Liaison Committee on Resuscitation Consensus Conference adopted the "5H+5T" acronym for the reversible causes of pediatric cardiac arrest: hypoxia, hypovolemia, hyper/hypokalemia, hypothermia, tension pneumothorax, cardiac tamponade, toxins, and cardiopulmonary thromboembolism. In this review article, the pathophysiology, diagnostic pathway, and treatment of perioperative cardiac arrest in children will be addressed. The importance of a certified training of anesthesiologists in pediatric advanced life support is also highlighted.

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Succinylcholine-Induced Hyperkalemia in Patients with Renal Failure: An Old Question Revisited

Cited by 58 publications

References 34 publications

Postoperative hyperkalemia

Postoperative hyperkalemia

Prevalencia de contraindicaciones a succinilcolina en unidades de cuidados intensivos

Cardiac Arrest in Children

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